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101.
Stuart D Breedon RE Kim GN Ko W Lander RL Maeshima K Malchow RL Smith JR Imlay R Kirk P Lim J McNeil RR Metcalf W Myung SS Cheng CP Gu P Li J Li YK Ye MH Zhu YC Abashian A Gotow K Hu KP Low EH Mattson ME Piilonen L Sterner KL Lusin S Rosenfeld C Wang AT Wilson S Frautschi M Kagan H Kass R Trahern CG Abe K Fujii Y Higashi Y Kim SK Kurihara Y Maki A Nozaki T Omori T Sagawa H Sakai Y Sugimoto Y Takaiwa Y Terada S Walker R Kajino F Perticone D Poling R Thomas T Ishi Y Miyano K Miyata H Sasaki T 《Physical review letters》1990,64(9):983-986
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Chiba J Iimura S Yoneda Y Sugimoto Y Horiuchi T Muro F Ochiai Y Ogasawara T Tsubokawa M Iigou Y Takayama G Taira T Takata Y Yokoyama M Takashi T Nakayama A Machinaga N 《Chemical & pharmaceutical bulletin》2006,54(11):1515-1529
A novel series of benzoic acid derivatives as VLA-4 antagonists were synthesized. Optimization, focusing on activity and lipophilicity needed for cell permeability, resulted in the identification of 15b and 15e with good activity (IC50 = 1.6 nM each) and moderate lipophilicity (Log D = 2.0, 1.8). Furthermore, 15e demonstrated efficacy in murine asthma model by an oral dose of 30 mg/kg. 相似文献
104.
This paper deals with the critical case of the global smoothing estimates for the Schrödinger equation. Although such estimates fail for critical orders of weights and smoothing, it is shown that they are still valid if one works with operators with symbols vanishing on a certain set. The geometric meaning of this set is clarified in terms of the Hamiltonian flow of the Laplacian. The corresponding critical case of the limiting absorption principle for the resolvent is also established. Obtained results are extended to dispersive equations of Schrödinger type, to hyperbolic equations and to equations of other orders. 相似文献
105.
Kyozo Kanamoto Sheng Lan Naoki Ikeda Yoshimasa Sugimoto Kiyoshi Asakawa Hiroshi Ishikawa 《光学学报》2003,23(Z1)
Single photonic crystal defects based on an air-bridge structure were fabricated. We obtained sharp defect modes with quality factors higher than 600 and observed their response to ultrashort optical pulses by utilizing two-photon absorption. 相似文献
106.
The extraction of lead from fly ash produced during the thermal treatment of municipal solid wastes was studied using supercritical carbon dioxide (SC-CO(2)) and Cyanex 302 (bis(2,4,4-trimethylpentyl)monophosphinic acid). The extraction of lead from the fly ash was carried out in a 5 cm(3) internal volume reaction vessel under static extraction conditions at 323 K, and 24 MPa for 1 h. The extraction efficiencies of lead ranged from 4% to the total extraction under the conditions of 0.05 g fly ash with 2 cm(3) Cyanex 302. There was a linear relationship between the extraction efficiencies of lead using the SC-CO(2) + Cyanex 302 and using a water-based method described by JLT13. 相似文献
107.
Preliminary communicationPalladium-catalyzed carboxylation of aromatic compounds with carbon dioxide
Hiroshi Sugimoto Itaru Kawata Hiroshi Taniguchi Yuzo Fujiwara 《Journal of organometallic chemistry》1984,266(3):c44-c46
Carbon dioxide has been found to react with aromatic compounds such as benzene, anisole, furane, and thiophene to give aromatic acids in modest yields with palladium(II) salts as catalysts. The addition of t-BuOOH increases the yield. 相似文献
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