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排序方式: 共有186条查询结果,搜索用时 31 毫秒
21.
Lelli M Gajan D Lesage A Caporini MA Vitzthum V Miéville P Héroguel F Rascón F Roussey A Thieuleux C Boualleg M Veyre L Bodenhausen G Copéret C Emsley L 《Journal of the American Chemical Society》2011,133(7):2104-2107
We demonstrate fast characterization of the distribution of surface bonding modes and interactions in a series of functionalized materials via surface-enhanced nuclear magnetic resonance spectroscopy using dynamic nuclear polarization (DNP). Surface-enhanced silicon-29 DNP NMR spectra were obtained by using incipient wetness impregnation of the sample with a solution containing a polarizing radical (TOTAPOL). We identify and compare the bonding topology of functional groups in materials obtained via a sol-gel process and in materials prepared by post-grafting reactions. Furthermore, the remarkable gain in time provided by surface-enhanced silicon-29 DNP NMR spectroscopy (typically on the order of a factor 400) allows the facile acquisition of two-dimensional correlation spectra. 相似文献
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23.
Stphane Mann Dominique Florentin Denis Lesage Thierry Drujon Olivier Ploux Andre Marquet 《Helvetica chimica acta》2003,86(11):3836-3850
The mechanism of action of amiclenomycin ( 1a ), a naturally occuring inhibitor of diaminopelargonic acid aminotransferase, has been established. The enzyme catalyzes the formation of an aromatic adduct between the inhibitor and pyridoxal‐5′‐phosphate. The structure of the adduct, determined by mass spectrometry, is in agreement with the reported X‐ray crystal structure. Kinetic parameters, characteristic of kcat inhibitors, have been observed, with a KI value of 2 μM and a kinact value of 0.4 min?1. The irreversibility of the inactivation observed, in spite of the absence of covalent bond between the inhibitor and the protein, reveals the high affinity of the adduct for the active site. Two other cis‐1‐amino‐4‐substituted‐cyclohexa‐2,5‐dienes, 3a and 4a , were also found to efficiently inhibit the enzyme. The trans‐isomers were either much less potent ( 1b ) or inactive ( 3b and 4b ). The aminocyclohexadiene moiety, which is, apparently, responsible for the inhibition, could constitute an original pharmacophore for the design of new herbicides. 相似文献
24.
We develop a unified theoretical framework for the anisotropic Kondo model and the boundary sine-Gordon model. They are both boundary integrable quantum field theories with a quantum-group spin at the boundary which takes values, respectively, in standard or cyclic representations of the quantum groupSU(2)
q. This unification is powerful, and allows us to find new results for both models. For the anisotropic Kondo problem, we find exact expressions (in the presence of a magnetic field) for all the coefficients in the Anderson-Yuval perturbative expansion. Our expressions hold initially in the very anisotropic regime, but we show how to continue them beyond the Toulouse point all the way to the isotropic point using an analog of dimensional regularization. The analytic structure is transparent, involving only simple poles which we determine exactly, together with their residues. For the boundary sine-Gordon model, which describes an impurity in a Luttinger liquid, we find the nonequilibrium conductance for all values of the Luttinger coupling. This is an intricate computation because the voltage operator and the boundary scattering do not commute with each other. 相似文献
25.
Mifsud N Elena B Pickard CJ Lesage A Emsley L 《Physical chemistry chemical physics : PCCP》2006,8(29):3418-3422
We show how powder samples at natural isotopic abundance can be assigned to crystal structures by using high-resolution proton and carbon-13 solid-state NMR spectra in combination with first principles calculations. Homonuclear proton double-quantum spectra in combination with through-bond proton-carbon HSQC spectra are used to assign the NMR spectra. We then show that the proton chemical shifts can be included in the process of assigning the spectra to a crystal structure using first principles calculations. The method is demonstrated on the K salt of penicillin G. 相似文献
26.
Martien A. Würdemann Cristina Niţu Dr. Stefaan M. A. De Wildeman Dr. Katrien V. Bernaerts Prof. Dr. Romano V. A. Orru 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(36):8090-8100
Pyrazines are an underreported class of N-heterocycles available from nitrogen-rich biomass presenting an interesting functional alternative for current aromatics. In this work, access to pyrazines obtained from amino acids by using the 90 year old Dakin–West reaction was explored. After a qualitative screening several functional proteinogenic amino acids proved good substrates for this reaction, which were successfully scaled to multigram scale synthesis of the corresponding intermediate α-acetamido ketones. Subsequently, the conditions towards pyrazine formation using δ-amino-levulinic acid were optimized, and these were employed to synthesize a relevant set of five functional dimethylpyrazines in high purity. These pyrazines can be considered a versatile toolbox of aromatic building blocks for a wide range of applications, such as in the synthesis of polymers or metal–organic frameworks. 相似文献
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28.
Emsley JW De Luca G Lesage A Longeri M Mallory FB Mallory CW 《Physical chemistry chemical physics : PCCP》2008,10(43):6534-6543
The (1)H, (19)F and (13)C spectra have been obtained of a sample of peri-difluoronaphthalene dissolved in the nematic liquid crystalline solvent ZLI 1695. The (13)C satellite spectra from the six, single-(13)C isotopomers at natural abundance in both the (1)H and (19)F spectra were identified and analysed to yield a set of residual total, anisotropic spin-spin couplings, T(ij). This was achieved by first obtaining residual (13)C-(19)F and (13)C-(1)H couplings from a proton-encoded, (13)C detected, local field 2D spectrum. The 45 values of T(HH), T(HF) and T(CH) were used to obtain the structure of the molecule, and then to estimate whether there is a significant contribution from the component along the magnetic field, J, of the anisotropic, electron-mediated, spin-spin coupling tensors for (13)C-(19)F and (19)F-(19)F pairs. It is found that there is strong evidence for a significant contribution of J to T(FF) but not for the (13)C-(19)F pairs. 相似文献
29.
The internal energy of ions and the timescale play fundamental roles in mass spectrometry. The main objective of this study is to estimate and compare the internal energy distributions of different ions (different nature, degree of freedom 'DOF' and fragmentations) produced in an electrospray source (ESI) of a triple-quadrupole instrument (Quattro I Micromass). These measurements were performed using both the Survival Yield method (as proposed by De Pauw) and the MassKinetics software (kinetic model introduced by Vékey). The internal energy calibration is the preliminary step for ESI and collision-induced dissociation (CID) spectra calculation. meta-Methyl-benzylpyridinium ion and four protonated peptides (YGGFL, LDIFSDF, LDIFSDFR and RLDIFSDF) were produced using an electrospray source. These ions were used as thermometer probe compounds. Cone voltages (V(c)) were linearly correlated with the mean internal energy values () carried by desolvated ions. These mean internal energy values seem to be slightly dependent on the size of the studied ion. ESI mass spectra and CID spectra were then simulated using the MassKinetics software to propose an empirical equation for the mean internal energy () versus cone voltage (V(c)) for different source temperatures (T): < E(int) > = [405 x 10(-6) - 480 x 10(-9) (DOF)] V(c)T + E(therm)(T). In this equation, the E(therm)(T) parameter is the mean internal energy due to the source temperature at 0 V(c). 相似文献
30.
Loquet A Laage S Gardiennet C Elena B Emsley L Böckmann A Lesage A 《Journal of the American Chemical Society》2008,130(32):10625-10632
A two-dimensional proton-mediated carbon-carbon correlation experiment that relies on through-bond heteronuclear magnetization transfers is demonstrated in the context of solid-state NMR of proteins. This new experiment, dubbed J-CHHC by analogy to the previously developed dipolar CHHC techniques, is shown to provide selective and sensitive correlations in the methyl region of 2D spectra of crystalline organic compounds. The method is then demonstrated on a microcrystalline sample of the dimeric protein Crh (2 x 10.4 kDa). A total of 34 new proton-proton contacts involving side-chain methyl groups were observed in the J-CHHC spectrum, which had not been observed with the conventional experiment. The contacts were then used as additional distance restraints for the 3D structure determination of this microcrystalline protein. Upon addition of these new distance restraints, which are in large part located in the hydrophobic core of the protein, the root-mean-square deviation with respect to the X-ray structure of the backbone atom coordinates of the 10 best conformers of the new ensemble of structures is reduced from 1.8 to 1.1 A. 相似文献