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71.
Katharina Jacob 《合成通讯》2014,44(9):1251-1257
Several triazoles have been synthesized. They were obtained by a Cu-catalyzed cycloaddition of azides and alkynes. The reaction takes place in aqueous media under microwave irradiation using a copper catalyst based on porous glass. The products have been characterized by infrared, gas chromatography–mass spectrometry, 1H NMR, and 13C NMR in addition to melting = point determination. Furthermore the in situ building of some azides and alkynes and the influence of the used metal species was investigated. 相似文献
72.
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74.
Patrick C. Dolder Matthias E. Liechti Katharina M. Rentsch 《Analytical and bioanalytical chemistry》2015,407(6):1577-1584
75.
Johannes Fickert David Schaeffel Kaloian Koynov Katharina Landfester Daniel Crespy 《Colloid and polymer science》2014,292(1):251-255
Redox-responsive silica nanocapsules with a hydrophobic liquid core were synthesized by reactive templating of miniemulsion droplets with functional alkoxysilanes. Tetrasulfide bridges were successfully introduced into the inorganic shell and were found to be accessible for chemical reactions as shown by 31P-NMR spectroscopy. Indeed, the tetrasulfide groups could be reduced to yield thiol groups. A subsequent increase of permeability of the silica shell was observed upon reduction of the tetrasulfide groups. 相似文献
76.
Spontaneous Formation of Microgroove Arrays on the Surface of p‐Type Porous Silicon Induced by a Turing Instability in Electrochemical Dissolution 下载免费PDF全文
Prof. Dr. Kazuhiro Fukami Tomoko Urata Prof. Dr. Katharina Krischer Prof. Dr. Naoya Nishi Prof. Dr. Tetsuo Sakka Dr. Atsushi Kitada Prof. Dr. Kuniaki Murase 《Chemphyschem》2015,16(8):1613-1618
Self‐organization plays an imperative role in recent materials science. Highly tunable, periodic structures based on dynamic self‐organization at micrometer scales have proven difficult to design, but are desired for the further development of micropatterning. In the present study, we report a microgroove array that spontaneously forms on a p‐type silicon surface during its electrodissolution. Our detailed experimental results suggest that the instability can be classified as Turing instability. The characteristic scale of the Turing‐type pattern is small compared to self‐organized patterns caused by the Turing instabilities reported so far. The mechanism for the miniaturization of self‐organized patterns is strongly related to the semiconducting property of silicon electrodes as well as the dynamics of their surface chemistry. 相似文献
77.
Inside Cover: Spontaneous Formation of Microgroove Arrays on the Surface of p‐Type Porous Silicon Induced by a Turing Instability in Electrochemical Dissolution (ChemPhysChem 8/2015) 下载免费PDF全文
78.
Nanorattles or Yolk–Shell Nanoparticles—What Are They,How Are They Made,and What Are They Good For? 下载免费PDF全文
Dr. Magdalena Priebe Prof. Dr. Katharina M. Fromm 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(10):3854-3874
The development of nanotechnology has led to the design of cutting‐edge nanomaterials with increasing levels of complexity. Although “traditional” solid, uniform nanoparticles are still the most frequently reported structures, new generations of nanoparticles have been constantly emerging over the last several decades. The outcome of this nano‐art extends beyond nanomaterials with alternative compositions and/or morphologies. The current state‐of‐the‐art allows for the design of nanostructures composed of different building blocks that exhibit diverse properties. Furthermore, those properties can be a reflection of either individual features, which are characteristic of a particular building block alone, and/or synergistic effects resulting from interactions between building blocks. Therefore, the unique structures as well as the outstanding properties of nanorattles have attracted increasing attention for possible biomedical and industrial applications. Although these nanoparticles resemble core–shell particles, they have a distinctive feature, which is a presence of a void that provides a homogenous environment for the encapsulated core. In this Review, we give a comprehensive insight into the fabrication of nanorattles. A special emphasis is put on the choice of building blocks as well as the choice of preparation method, because those two aspects further influence properties and thus possible future applications, which will also be discussed. 相似文献
79.
M.Sc. Katharina Heller M.Sc. Philipp Ochtrop M.Sc. Michael F. Albers Florian B. Zauner Prof. Dr. Aymelt Itzen Prof. Dr. Christian Hedberg 《Angewandte Chemie (International ed. in English)》2015,54(35):10327-10330
We present a new protein labeling method based on the covalent enzymatic phosphocholination of a specific octapeptide amino acid sequence in intact proteins. The bacterial enzyme AnkX from Legionella pneumophila has been established to transfer functional phosphocholine moieties from synthetically produced CDP‐choline derivatives to N‐termini, C‐termini, and internal loop regions in proteins of interest. Furthermore, the covalent modification can be hydrolytically removed by the action of the Legionella enzyme Lem3. Only a short peptide sequence (eight amino acids) is required for efficient protein labeling and a small linker group (PEG‐phosphocholine) is introduced to attach the conjugated cargo. 相似文献
80.
Fragment‐Based De Novo Design Reveals a Small‐Molecule Inhibitor of Helicobacter Pylori HtrA 下载免费PDF全文
Thomas P. Schmidt Dr. Manja Böhm Katharina Stutz Daniel Reker Dr. Bernhard Pfeiffer Prof. Dr. Karl‐Heinz Altmann Prof. Dr. Steffen Backert Prof. Dr. Silja Wessler Prof. Dr. Gisbert Schneider 《Angewandte Chemie (International ed. in English)》2015,54(35):10244-10248
Sustained identification of innovative chemical entities is key for the success of chemical biology and drug discovery. We report the fragment‐based, computer‐assisted de novo design of a small molecule inhibiting Helicobacter pylori HtrA protease. Molecular binding of the designed compound to HtrA was confirmed through biophysical methods, supporting its functional activity in vitro. Hit expansion led to the identification of the currently best‐in‐class HtrA inhibitor. The results obtained reinforce the validity of ligand‐based de novo design and binding‐kinetics‐guided optimization for the efficient discovery of pioneering lead structures and prototyping drug‐like chemical probes with tailored bioactivity. 相似文献