全文获取类型
收费全文 | 1352篇 |
免费 | 36篇 |
专业分类
化学 | 1158篇 |
晶体学 | 15篇 |
力学 | 9篇 |
数学 | 67篇 |
物理学 | 139篇 |
出版年
2024年 | 2篇 |
2023年 | 20篇 |
2022年 | 118篇 |
2021年 | 109篇 |
2020年 | 38篇 |
2019年 | 34篇 |
2018年 | 38篇 |
2017年 | 37篇 |
2016年 | 79篇 |
2015年 | 45篇 |
2014年 | 57篇 |
2013年 | 102篇 |
2012年 | 85篇 |
2011年 | 98篇 |
2010年 | 67篇 |
2009年 | 56篇 |
2008年 | 74篇 |
2007年 | 73篇 |
2006年 | 46篇 |
2005年 | 52篇 |
2004年 | 37篇 |
2003年 | 30篇 |
2002年 | 26篇 |
2001年 | 8篇 |
2000年 | 7篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 8篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有1388条查询结果,搜索用时 12 毫秒
41.
42.
Anna Gumieniczek Justyna Galeza Tomasz Mroczek Krzysztof Wojtanowski Katarzyna Lipska Rafał Pietras 《Chromatographia》2018,81(8):1147-1162
Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presence of their degradation products. Finally, the degradation products were characterized through LC-DAD and LC–MS methods. Dihydralazine was sensitive to high temperature and humidity, UV/Vis light and pH?≥?7. At the same time, it was resistant to acidic conditions. Hydrochlorothiazide was sensitive to high temperature and humidity, UV/Vis light and changes in pH. Its highest level of degradation was observed in 1 M HCl. Degradation of the drugs was higher when they were stressed in the mixture. In the case of dihydralazine, the percentage degradation was 5–15 times higher. What is more, dihydralazine became sensitive to acidic conditions. Hydrochlorothiazide was shown to be more sensitive to UV/Vis light and pH?>?4. Degradation of dihydralazine and hydrochlorothiazide followed first-order kinetics. The quickest degradation of dihydralazine was found to be in 1 M NaOH while of hydrochlorothiazide was in 1 M HCl (individual hydrochlorothiazide) or at pH 7–10 (hydrochlorothiazide in the mixture). A number of new degradation products were detected and some of them were identified by our LC-DAD and LC–MS methods. In the stressed individual samples, (phenylmethyl)hydrazine and 1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide were observed for the first time. Interactions between dihydralazine and hydrochlorothiazide in the mixture were confirmed by additional degradation products, e.g., 2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1,4-trioxide. 相似文献
43.
The lipophilicity of the series of alpha-(4-phenylpiperazin-1-yl)-gamma-phthalimido-butyramides (1-8) has been investigated. Several methods, like reversed-phase thin-layer chromatography and high-performance liquid chromatography using reversed-phase RP18 and IAM.DD2 columns, were applied to determine RMO, log k0 and log k(0IAM) factors. The RP-TLC investigations were performed in mixtures of acetone-water and acetonitrile-water. For RP-HPLC method mixtures of acetonitrile, water and 0.01% TFA were used as the mobile phases while for IAM.DD2 investigations mixtures of acetonitrile and water were applied. The partition coefficients of compounds (1-8) were also calculated with the Pallas and CAChe programs. All the obtained data, both from experimental methods and computational calculations, were compared and a suitable conclusion was reached. 相似文献
44.
Nanoparticle self-assembly at fluid-fluid interfaces has been traditionally exploited in emulsification, encapsulation and oil recovery, and more recently in emerging applications including functional nanomaterials and biphasic catalysis. We provide a review of the literature focusing on the open challenges that still hamper the broader applicability of this potentially transformative technology, and we outline strategies to achieve improved control over interfacial self-assembly of nanoparticles. First, we discuss means to promote spontaneous adsorption by tuning the interfacial energies of the nanoparticles with the fluids using capping ligands, and the occurrence of energy barriers. We then examine the interactions between interfacial nanoparticles and how they affect the formation of equilibrium interfacial suspensions versus non-equilibrium two-dimensional phases, such as weakly attractive glasses and gels. Important differences with colloidal interactions in a bulk suspension arise due to the discontinuity in solvent properties at the interface. For instance, ligand brushes rearrange in asymmetric configurations, and thus play a significant role in determining interparticle interactions. Finally, we briefly discuss the link between interfacial microstructure and the dynamic response of particle-laden interfaces, including interfacial rheology and the fate of nanoparticle monolayers upon out-of-plane deformation. 相似文献
45.
46.
Katarzyna Samson Anna Klisiska Irena Gressel Barbara Grzybowska 《Reaction Kinetics and Catalysis Letters》2002,77(2):309-315
VOx/TiO2 and MoOx/TiO2 catalysts with the addition of Re (Re/V or Mo = 0.5) were synthetized and tested in oxidative dehydrogenation of propane and in reduction by propane. XPS measurements showed depletion of the surface in Re. The Re additive does not affect the total conversion of propane, but increases the selectivity to propene. The effect is more pronounced for the MoOx/TiO2 catalyst. The increase in the selectivity to propene is accompanied with the increase in the reducibility of the catalysts. 相似文献
47.
A micro extraction – spectrophotometric procedure is developed for the determination of bismuth in pharmaceutical formulations.
The procedure is based on the extraction of tetraiodobismuthate(III) ion paired with benzyltributylammonium cation into chloroform.
The application of Nile Blue as internal standard (IS) enabled good analytical performance for micro-scale analysis. The ratio
between the absorbances measured at 491 nm (bismuth complex) and at 632 nm (IS) was taken as the analytical signal. The procedure
was carried out in Eppendorf tubes, lowering significantly the use of reagents and the volume of organic solvent. In the calibration
range up to 60 mgċl−1, the linear regression coefficient was 0.9999, the CV for 15 mgċl−1 and for 50 mgċl−1 Bi were 1.6% and 0.7% respectively. The results obtained in the analysis of pharmaceutical formulations were in good agreement
with the results of EDTA titration method.
Received November 25, 1999. Revision February 14, 2000. 相似文献
48.
Piotr Ziba Agnieszka Skara Emilia Berna Agata Krakowska Katarzyna Sukowska-Ziaja Edward Kunicki Magorzata Suchanek Boena Muszyska 《Molecules (Basel, Switzerland)》2021,26(11)
The use of substrates supplemented with minerals is a promising strategy for increasing the nutraceutical value of Pleurotus spp. The current research was performed to analyze the effect of substrate supplementation with magnesium (Mg) salts on the Mg content, biomass, and chemical composition of pink oyster mushroom (Pleurotus djamor) fruiting bodies. Before inoculation, substrate was supplemented with MgCl2 × 6 H2O and MgSO4, both salts were applied at three concentrations: 210, 420, and 4200 mg of Mg per 2 kg of substrate. The harvest period included three flushes. Substrate supplementation with 4200 mg of Mg caused the most significant decrease in mushroom productivity, of about 28% for both Mg salts. The dry matter content in fruiting bodies was significantly lower in the treatment in which 210 mg of Mg was applied as MgSO4 in comparison to the control. Supplementation effectively increased the Mg content in fruiting bodies of P. djamor by 19–85% depending on the treatment, and significantly affected the level of remaining bioelements and anions. One hundred grams of pink oyster fruiting bodies, supplemented with Mg salts, provides more than 20% of the Mg dietary value recommended by the Food and Drug Administration (FDA); thus, supplementation can be an effective technique for producing mushrooms that are rich in dietary Mg. Although P. djamor grown in supplemented substrate showed lower productivity, this was evident only in the fresh weight because the differences in dry weight were negligible. Mg supplementation increased the antioxidant activity of the fruiting bodies, phenolic compounds, and some amino acids, including L-tryptophan, and vitamins (thiamine and l-ascorbic acid). 相似文献
49.
Paulina Lewandowska Izabela Szczuka Iwona Bednarz-Misa Berenika M. Szczniak-Siga Katarzyna Neubauer Magdalena Mierzchaa-Pasierb Marek Zawadzki Wojciech Witkiewicz Magorzata Krzystek-Korpacka 《Molecules (Basel, Switzerland)》2021,26(23)
The mechanisms underlying the antineoplastic effects of oxicams have not been fully elucidated. We aimed to assess the effect of classic and novel oxicams on the expression/secretion of macrophage-associated chemokines (RTqPCR/Luminex xMAP) in colorectal adenocarcinoma cells, and on the expression of upstream the non-steroidal anti-inflammatory drug (NSAID)-activated genes NAG1, NFKBIA, MYD88, and RELA, as well as at the chemokine profiling in colorectal tumors. Meloxicam downregulated CCL4 9.9-fold, but otherwise the classic oxicams had a negligible/non-significant effect. Novel analogues with a thiazine ring substituted with arylpiperazine and benzoyl moieties significantly modulated chemokine expression to varying degree, upregulated NAG1 and NFKBIA, and downregulated MYD88. They inhibited CCL3 and CCL4, and their effect on CCL2 and CXCL2 depended on the dose and exposure. The propylene linker between thiazine and piperazine nitrogens and one arylpiperazine fluorine substituent characterized the most effective analogue. Only CCL19 and CXCL2 were not upregulated in tumors, nor was CXCL2 in tumor-adjacent tissue compared to normal mucosa. Compared to adjacent tissue, CCL4 and CXCL2 were upregulated, while CCL2, CCL8, and CCL19 were downregulated in tumors. Tumor CCL2 and CCL7 increased along with advancing T and CCL3, and CCL4 along with the N stage. The introduction of arylpiperazine and benzoyl moieties into the oxicam scaffold yields effective modulators of chemokine expression, which act by upregulating NAG1 and interfering with NF-κB signaling. 相似文献
50.
Filip Ciesielczyk Przemysław Bartczak Karolina Wieszczycka Katarzyna Siwińska-Stefańska Magdalena Nowacka Teofil Jesionowski 《Adsorption》2013,19(2-4):423-434
The aim of this work was to obtain an inorganic oxide system containing silica and magnesium oxide, and characterized by specific physicochemical properties, in particular well-defined adsorption parameters. The preparation process was carried out according to a co-precipitation method using solutions of sodium silicate and selected inorganic magnesium salt. The oxide system obtained (MgO·SiO2) was used as a support (adsorbent) of nickel(II) ions, whose precursors were model solutions of nitrates. The effectiveness of the adsorption process was evaluated using many different analytical techniques, including atomic absorption spectroscopy, energy dispersive X-ray spectroscopy and equivalent point titration. Moreover the stability of adsorbent/adsorbate bonding was estimated. The oxide systems—adsorbents—used in the process were also analyzed according to their physicochemical properties, especially changes in adsorption parameters. The last part of the study involved evaluation of the kinetics of the adsorption process depending on time and the pH of the reaction system. 相似文献