Densitometric Determination of Omeprazole,Pantoprazole, and their Impurities in Pharmaceuticals

JPC – Journal of Planar Chromatography – Modern TLC - A method has been developed for separation of omeprazole and pantoprazole, and their impurities omeprazole sulfone and...     

Crystal Structure of Metal-Ion Complexes with neutral noncyclic Ionophores

Crystal structure determinations of two metal-ion complexes with noncyclic ionophores are reported: (i) CaCl₂ complex of N,N,N′,N′-Tetrapropyl-3,6-dioxa-octane diamide, space group Fddd, a = 14.659, b = 19.616, c = 33.173 Å; (ii) MnBr₂ complex of N,N,N′,N′-Tetrapropyl-1,2-cyclohexylenedioxydiacetamide, space group I4 , a = b = 11.695, c = 21.299 Å.     

On the need of nonlinear control for efficient model-based wake stabilization

The mitigation of oscillatory vortex shedding behind a cylinder is chosen as a well-investigated benchmark problem to compare model-based feedback flow control approaches. The flow is sensed by a single velocity signal in the wake and is manipulated via a single volume force actuator. A low-dimensional proper orthogonal decomposition Galerkin model is adopted as a control-oriented fluid flow representation. An extended Kalman filter is used as an effective means for online dynamic state estimation. Investigated strategies of linear and nonlinear controller design include pole placement, linear parameter-varying, input–output linearization, Lyapunov-based backstepping, and nonlinear model predictive control. These strategies are applicable to a large class of flows with oscillatory dynamics and to experimental conditions, where variants have already been used. Controllers are evaluated and compared based on their application to the full plant, that is, to the direct numerical simulation of the wake, emulating an experiment with a single hot-wire sensor. Overall, nonlinear closed-loop control is shown to be distinctly superior to linear approaches. As is often the case, physics dictates a similarity of successful control commands, irrespective of the design approach, and differentiates these controllers, as a group, from less successful approaches.     

Morphology of magnetically aligning DMPC/DHPC aggregates-perforated sheets, not disks

The morphology of DMPC/DHPC mixtures at total lipid concentration cL = 5% (w/w) and DMPC/DHPC ratio q approximately 3, doped with small amounts of DMPG or CTAB, was investigated. 31P NMR was used to identify the magnetically aligning phase, and cryo-transmission electron microscopy (cryo-TEM) was employed for structural characterization. Magnetic alignment was found to occur between approximately 30 and approximately 45 degrees C, and cryo-TEM showed that the magnetically aligning phase consisted of extended sheets with a lacelike structure. The aggregates are best described as intermediates between two-dimensional networks of flattened, highly branched, cylindrical micelles and lamellar sheets perforated by large irregular holes. DHPC most likely covers the edges of the holes, while DMPC makes up the bilayer bulk of the aggregates. However, 20-43% of the DHPC takes part in the bilayer, corresponding to 6-12% of the bilayer being made up of DHPC. This fraction increases with increasing temperature. At temperatures above 45 degrees C, the aligning phase collapses.     

Intrinsic heterogeneity in liposome suspensions caused by the dynamic spontaneous formation of hydrophobic active sites in lipid membranes

The spontaneous, dynamic formation of hydrophobic active sites in lipid bilayer membranes is studied and characterized. It is shown that the rates of formation and consumption of these active sites control at least two important properties of liposomes: their affinity for hydrophobic surfaces and the rate by which they spontaneously release encapsulated molecules. The adhesion and spreading of liposomes onto hydrophobic polystyrene nanoparticles and the spontaneous leakage of an encapsulated fluorescent dye were monitored for different liposome compositions employing Cryo-TEM, DLS, and fluorescence measurements. It was observed that an apparently homogeneous, monodisperse liposome suspension behaves as if composed by two different populations: a fast leaking population that presents affinity for the hydrophobic substrate employed, and a slow leaking population that does not attach immediately to it. The results reported here suggest that the proportion of liposomes in each population changes over time until a dynamic equilibrium is reached. It is shown that this phenomenon can lead to irreproducibility in, for example, spontaneous leakage experiments, as extruded liposomes leak much faster just after preparation than 24 h afterward. Our findings account for discrepancies in several experimental results reported in the literature. To our knowledge, this is the first systematic study addressing the issue of an existing intrinsic heterogeneity of liposome suspensions.     

Stoffwechselprodukte von Mikroorganismen 198. Mitteilung Die Eurekansäure,ein Abbauprodukt von Flambamycin und Avilamycin: Konfigurationsbestimmung durch Röntgenstrukturanalyse und Abbau

Eurekanic Acid, a Degradation Product of Flambamycin and Avilamycin: Determination of the Configuration by X-Ray Structural Analysis and Degradation The relative configuration of methyl O-acetyleurekanate (6) , obtained by mild methanolysis of avilamycin A (2) and subsequent acetylation, was determined by an X-ray structural investigation. Methyl dihydroeurekanate (7) , similarly obtained from avilamycin C (3) and from reduced avilamycin A methyl ether, was degraded to L-threonolactone (14) which allowed to determine the chirality of eurekanic acid (4).