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11.
Katarína Kla?anová Peter Fodran Michal Rosenberg 《Monatshefte für Chemie / Chemical Monthly》2010,223(5):823-828
Abstract
This work describes the degradation of phenylalanine and tryptophane catalysed by their complexes with Fe(II), Co(II), and Cu(II). The influences of the central atom and of the reaction conditions on the degradation of the amino acids were observed. The necessary condition of the degradation is the possibility of a redox reaction on the central atom between M(II) and M(III). Moreover, the coordination sphere of the central cation of the transition metal must not be sterically shielded. The necessary conditions are fulfilled only in the Fe(II) complexes. The degradation is strictly anaerobic because due to the influence of oxygen, an irreversible oxidation of Fe(II) to Fe(III) proceeds. This reaction results in 5-hydroxy-1H-indol instead of the mixture of the degradation products, such as benzaldehyde, phenylacetaldehyde, and phenylacetic acid. The influence of the temperature on the catabolism is very important because the reaction accelerates with temperature increase. The phenylalanine anion acts as a reducing agent, and Fe(II) is spontaneously reduced to Fe(0). 相似文献12.
Peltier P Beláňová M Dianišková P Zhou R Zheng RB Pearcey JA Joe M Brennan PJ Nugier-Chauvin C Ferrières V Lowary TL Daniellou R Mikušová K 《Chemistry & biology》2010,17(12):1356-1366
UDP-galactofuranose (UDP-Galf) is a substrate for two types of enzymes, UDP-galactopyranose mutase and galactofuranosyltransferases, which are present in many pathogenic organisms but absent from mammals. In particular, these enzymes are involved in the biosynthesis of cell wall galactan, a polymer essential for the survival of the causative agent of tuberculosis, Mycobacterium tuberculosis. We describe here the synthesis of derivatives of UDP-Galf modified at C-5 and C-6 using a chemoenzymatic route. In cell-free assays, these compounds prevented the formation of mycobacterial galactan, via the production of short "dead-end" intermediates resulting from their incorporation into the growing oligosaccharide chain. Modified UDP-furanoses thus constitute novel probes for the study of the two classes of enzymes involved in mycobacterial galactan assembly, and studies with these compounds may ultimately facilitate the future development of new therapeutic agents against tuberculosis. 相似文献
13.
14.
Erika Szunyogová Katarína Györyová Daniela Hudecová Lenka Piknová J. Chomič Zuzanna Vargová V. Zeleňák 《Journal of Thermal Analysis and Calorimetry》2007,88(1):219-223
The thermal decomposition of the complexes Zn(form)2⋅2phen
(I), Zn(ac)2⋅2phen
(II), Zn(prop)2⋅2phen
(III), Zn(but)2⋅2phen
(IV), where phen=phenazone, form=formiate,
ac=acetate, prop=propionate, but=butyrate has been studied in air by TG/DTG
and DTA methods. The possible mechanism of the thermal decomposition was proposed.
The final product of thermal decomposition was ZnO. IR data show unidentate
coordination of carboxylate group to Zn(II) ion. The complexes were tested
against various strains of microorganisms and their efficiency decrease in
the sequence yeasts >bacteria>filamentous fungi. 相似文献
15.
Dominika Topol’ská Katarína Valachová Peter Rapta Stanislav Šilhár Elena Panghyová Anton Horváth Ladislav Šoltés 《Chemical Papers》2015,69(9):1202-1210
Potential protective effects of elderberry (Sambucus nigra) extracts against oxidative degradation of hyaluronan (HA) were detected in vitro. To induce free-radical-mediated HA degradation, Weissberger’s biogenic oxidative system, which mimics the situation of acute inflammation, was applied. Time- and dose-dependent changes of dynamic viscosity of the HA solutions in the presence and absence of two elderberry extracts produced in 2006 and 2012 were recorded by rotational viscometry (RV). Radical scavenging capacity of both extracts was investigated by the spectrocolorimetric ABTS [2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] assay and the “inverted” ABTS assay. Oxygen consumption of the system oxidizing HA either in the absence or presence of the elderberry extracts was determined. The results of RV revealed that an addition of the newer extract (2012) promoted the inhibition of HA degradation more markedly compared to the older extract (2006). The same effect of both extracts on ABTS·+ scavenging was observed. Inverted ABTS assay demonstrated that colorful substances were not responsible for the radical-scavenging activity. Results of oximetry demonstrated that the effect of the extract from 2006 was more significant than that of the extract from 2012. 相似文献
16.
In this work the kinetics of the high-temperature oxidation of the powder amorphous carbon and bulk single-wall carbon nanotubes is studied. The thermal degradation of the sample is measured by differential scanning calorimetry using the continuous heating regime up to 1273 K. Also, the oxidation resistance of the samples is evaluated by the mass loss in a thermogravimetric analyzer. Both flowing and static oxygen and dry-air atmospheres are used. The specific role of the external diffusivity of the reagent gas is analyzed. The kinetics of the chemical reaction is specified using the Kissinger, Coats and Redfern methods. 相似文献
17.
Štefan Stankovský Michal Bodajla Katarína Špirková 《Chemistry of Heterocyclic Compounds》1995,31(10):1211-1212
Department of Organic Chemistry, Slovak Technical University, 812 37 Bratislava, Slovak Republic. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1383–1384, October, 1995. Original article submitted August 24, 1995. 相似文献
18.
3T3 and VH10 cells were subjected to oxidative damage by hydroxyl radicals generated from Cu(II) ions and ascorbate. The presence of reactive oxygen and nitrogen species in cells was determined using fluorescent dyes. MitoQ—a mitochondrially targeted antioxidant—was examined to prevent cell death and was compared with trolox as a reference standard serving as an antioxidant. MitoQ at lower concentrations (up to 500 nM) prevented damage of mitochondria and thereby increased viability of cells. However, at higher concentrations (over 500 nM) MitoQ decreased the viability of both strains of cells. The last observation indicates that the application of MitoQ should be evaluated also from the point of its cell-destructive potential. 相似文献
19.
20.
Mikus P Maráková K Marák J Kaniansky D Valásková I Havránek E 《Journal of chromatography. A》2008,1179(1):9-16
The present work illustrated possibilities of column coupling electrophoresis combined with ionizable chiral selector and diode array detection (DAD) for the enantioselective analysis of trace drugs (pheniramine and its analogs) in pharmaceutical and clinical samples. Isotachophoresis (ITP), on-line coupled with capillary zone electrophoresis (CZE), served as an ideal injection technique (high sample load capacity, narrow and sharp drugs zones) of on-line pretreated samples (preseparation, purification and preconcentration of drugs) for the CZE stage. Enhanced (enantio)separation selectivity of CZE with ionizable chiral selector (carboxyethyl-beta-cyclodextrin recognized between drugs enantiomers on one hand as well as between drugs and sample matrix constituents on the other hand) enabled to obtain pure zones of the drugs enantiomers, suitable for their detection and quantitation. DAD in comparison with single wavelength UV detection enhanced value of analytical information verifying purity of drugs enantiomers zones (indicating interferents with different spectra to those of drugs). Obtained results indicated pure zones of interest confirming effective ITP-CZE (enantio)separation process. Distinguishing the trace analytes signals superposed on the baseline noise was provided with sufficient reliability (for this purpose the background correction and smoothing procedure had to be applied to the raw DAD spectra). The proposed ITP-CZE-DAD methods were characterized by favorable performance parameters (sensitivity, linearity, precision, recovery, accuracy, robustness, selectivity) and successfully applied for (i) enantiomeric purity testing of dexbrompheniramine in commercial pharmaceutical tablets and (ii) enantioselective metabolic study of pheniramine in human urine. 相似文献