Laser-Induced Breakdown Spectroscopy (LIBS) was applied to the analysis of bio-ceramic samples. The relationship between sample hardness and LIBS plasma properties was investigated, with comparison to conventional Vickers hardness measurements. The plasma excitation temperature Te was determined using the line-to-continuum ratio for the Si (I) 288.16 nm emission line; we have demonstrated a linear relationship between sample surface hardness and plasma temperature. Results indicate that hardness determination based on measurements of Te offers greater reproducibility than Vickers hardness measurements, under the conditions considered here. The validity of spectroscopic diagnostics based on LTE was confirmed. 相似文献
The ability to identify fragments that interact with a biological target is a key step in FBDD. To date, the concept of fragment
based drug design (FBDD) is increasingly driven by bio-physical methods. To expand the boundaries of QSAR paradigm, and to
rationalize FBDD using In silico approach, we propose a fragment based QSAR methodology referred here in as FB-QSAR. The FB-QSAR methodology was validated
on a dataset consisting of 52 Hydroxy ethylamine (HEA) inhibitors, disclosed by GlaxoSmithKline Pharmaceuticals as potential anti-Alzheimer agents. To address the issue of target selectivity, a major confounding factor
in the development of selective BACE1 inhibitors, FB-QSSR models were developed using the reported off target activity values.
A heat map constructed, based on the activity and selectivity profile of the individual R-group fragments, and was in turn
used to identify superior R-group fragments. Further, simultaneous optimization of multiple properties, an issue encountered
in real-world drug discovery scenario, and often overlooked in QSAR approaches, was addressed using a Multi Objective (MO-QSPR)
method that balances properties, based on the defined objectives. MO-QSPR was implemented using Derringer and Suich desirability
algorithm to identify the optimal level of independent variables (X) that could confer a trade-off between selectivity and activity. The results obtained from FB-QSAR were further substantiated
using MIF (Molecular Interaction Fields) studies. To exemplify the potentials of FB-QSAR and MO-QSPR in a pragmatic fashion,
the insights gleaned from the MO-QSPR study was reverse engineered using Inverse-QSAR in a combinatorial fashion to enumerate
some prospective novel, potent and selective BACE1 inhibitors. 相似文献
Two novel cocrystals of the N(7)—H tautomeric form of N6‐benzoyladenine (BA), namely N6‐benzoyladenine–3‐hydroxypyridinium‐2‐carboxylate (3HPA) (1/1), C12H9N5O·C6H5NO3, (I), and N6‐benzoyladenine–DL‐tartaric acid (TA) (1/1), C12H9N5O·C4H6O6, (II), are reported. In both cocrystals, the N6‐benzoyladenine molecule exists as the N(7)—H tautomer, and this tautomeric form is stabilized by intramolecular N—H...O hydrogen bonding between the benzoyl C=O group and the N(7)—H hydrogen on the Hoogsteen site of the purine ring, forming an S(7) motif. The dihedral angle between the adenine and phenyl planes is 0.94 (8)° in (I) and 9.77 (8)° in (II). In (I), the Watson–Crick face of BA (N6—H and N1; purine numbering) interacts with the carboxylate and phenol groups of 3HPA through N—H...O and O—H...N hydrogen bonds, generating a ring‐motif heterosynthon [graph set R22(6)]. However, in (II), the Hoogsteen face of BA (benzoyl O atom and N7; purine numbering) interacts with TA (hydroxy and carbonyl O atoms) through N—H...O and O—H...O hydrogen bonds, generating a different heterosynthon [graph set R22(4)]. Both crystal structures are further stabilized by π–π stacking interactions. 相似文献
The effect of surface preparation on CdZnTe properties was investigated. Surface etching using bromine solutions enhances Te elemental composition, resulting in a Te rich surface layer that is prone to oxidize. This oxidation degrades the performance of the fabricated CZT gamma detector. Roughness results were identical for samples polished with 1 and 3 μm and subsequently etched in 2% Br-MeOH. The optimal concentration of etching was 2% Br-MeOH. 相似文献
Mild reaction conditions are the advantage of the title reaction, which allows straightforward entry to a variety of ynamides starting from readily available 1,1‐dibromo‐1‐alkenes, which act as attractive alkynylating agents (see scheme; EWG=electron‐withdrawing group, DMF=N,N‐dimethylformamide).
Raman spectra of phenoxyacetic acid and chlorine substituted phenoxyacetic acids viz., o-chlorophenoxyacetic acid, p-chlorophenoxyacetic acid and 2,6-dichlorophenoxyacetic acid have been analysed with the aid of abinitio theoretical calculations. The effect of chlorine substituents on the Raman spectra of phenoxyacetic acid have also been analysed by considering some important vibrational modes. 相似文献
This is the first publication which describes the development of a reference material (RM) for the determination of 11 trace elements (Cu, Pb, Mn, Ni, Zn, Fe, Cd, Co, V, As and Al) in rainwater at microgram per liter concentrations. An interlaboratory comparison study for the determination of trace elements in rainwater was carried out for material performance studies to establish analyte concentrations with a stated uncertainty. Fifteen reputed laboratories from Asia, Europe and North America participated in the study. These laboratories used their regular in-house methods to analyze the rainwater samples. The aim of this study is to establish concentration levels of trace elements in rainwater based on interlaboratory study results. Details of the production, homogeneity and stability of the reference sample are given in this article. The organization of the study and the quality assurance measures undertaken at the organizer's laboratory are described. The analytical results obtained from individual laboratories and the analytical methods used for the determination of trace elements in rainwater are discussed. Based on the results obtained from the intercomparison study, certified values as well as informative values are assigned to the 11 trace elements in rainwater. 相似文献
Continuous review and periodic review inventory models in which a fraction of demand is backordered and the remaining fraction is lost during the stockout period are considered under fuzzy environment. Fuzziness is introduced by allowing the cost components imprecise and vague to certain extent. Trapezoidal fuzzy numbers are used to represent these characteristics. The optimum policies of these models under fuzzy costs are derived. Numerical results highlighting the sensitivity in the decision variables are also described. 相似文献
This paper reports the study of surface charge characteristics of bio-magnetoelectrets of amino acid l-serine. Electrets were prepared under the combined effect of heat and magnetic field. Three different forming temperatures and five different magnetic fields were used for the study. The bio-magnetoelectrets prepared this way were observed to have a surface charge of the order of 10?9 C. The decay of surface charge was studied continuously for 20 days and corresponding time constant was calculated. The comparative studies of surface charge characteristics were done by preparing bio-magnetoelectrets using homogeneous and inhomogeneous magnetic fields. 相似文献