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91.
Adéla?Zemanová Olga?Semenova Ale??Kroupa Jan?V?e?t’álEmail author Karthik?Chandrasekaran Klaus W.?Richter Herbert?Ipser 《Monatshefte für Chemie / Chemical Monthly》2005,136(11):1931-1937
Summary. Phase equilibria in the Ag–In–Pd system were determined at 700°C based on experimental results for 21 alloys. A ternary compound
T1 (with the approximate composition AgInPd2) was identified by XRD analysis. These data were compared with the results of a CALPHAD-type prediction, based on binary
thermodynamic data only and a symmetrical Redlich–Kister–Muggianu model. The experimental results will serve as a basis for refined thermodynamic modeling of the different phases in this
ternary system. 相似文献
92.
Three‐Arm,Biotin‐Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting,Sensing, and Photoresponsive Anticancer Drug Delivery 下载免费PDF全文
Yarra Venkatesh Dr. S. Karthik Y. Rajesh Prof. Mahitosh Mandal Dr. Avijit Jana Prof. N. D. Pradeep Singh 《化学:亚洲杂志》2016,11(24):3482-3486
The design, synthesis, and in vitro biological studies of a biotin–carbazole–dicyanovinyl–chlorambucil conjugate (Bio‐CBZ‐DCV‐CBL; 6 ) are reported. This conjugate ( 6 ) is a multifunctional single‐molecule appliance composed of a thiol‐sensor DCV functionality, a CBZ‐derived phototrigger as well as fluorescent reporter, and CBL as the anticancer drug, and Bio as the cancer‐targeting ligand. In conjugate 6 , the DCV bond undergoes a thiol–ene click reaction at pH<7 with intracellular thiols, thereby shutting down internal charge transfer between the donor CBZ and acceptor DCV units, resulting in a change of the fluorescence color from green to blue, and thereby, sensing the tumor microenvironment. Subsequent photoirradiation results in release of the anticancer drug CBL in a controlled manner. 相似文献
93.
Maheshwari Gourab Subramanian Ganesa Sundararajan Karthik Arumugam Ranjithkumar Averineni Ginjupalli Prashant Musmade Kishore Udupa Nayanabhirama 《平面色谱法杂志一现代薄层色谱法》2007,20(5):335-339
JPC – Journal of Planar Chromatography – Modern TLC - A sensitive, accurate, precise, and stability-indicating high-performance thin-layer chromatographic method has been established... 相似文献
94.
95.
Sankaranarayanan Kavitha Ramachandran Raja Prabhu Kumar Raghavan Muralitharen Sinthu S. Mansoor Usman M. Sriram Kumar V. Madan Kumar S. Vignesh V. Malini K.M. Cherian S. Madhivanan Sankaranarayanan Karthik Natarajan Arutselvan Sundararajan Raji 《Journal of Electrostatics》2011,69(4):267-274
Clinically chemo-resistant types of cancers do not respond well to conventional therapies. To treat and enhance the efficacy of drug delivery for these cancers, we have developed an in vitro model of a combination therapy using adult human mesenchymal stem cells, electrical pulses and chemo drug. Adult Mesenchymal stem cells were used because they are similar to cancer stem cells which cause the tumor to be chemo- and radiation resistant. These cells, derived from human adult bone marrow were subjected to low voltage, long duration (200 V/cm, 40 ms and 450 V/cm, 25 ms) and high voltage, short duration (1200 V/cm, 100 μs) pulses. The effect of these voltages on the viability and proliferation ability of these cells in the presence and absence of Bleomycin (chemodrug used for treating various cancers, FDA approved in US and other respective medical agencies in other countries,) indicate the potential of transfer of this technique to clinical practice for effective electro-targeted stem cell therapy. 相似文献
96.
Ru‐Catalysed CH Arylation of Indoles and Pyrroles with Boronic Acids: Scope and Mechanistic Studies 下载免费PDF全文
Carina Sollert Karthik Devaraj Dr. Andreas Orthaber Dr. Paul J. Gates Dr. Lukasz T. Pilarski 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(14):5380-5386
The Ru‐catalysed C2?H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range of functional groups on both coupling partners, including bromides and iodides, which can be further derivatised selectively. New indole‐based ruthenacyclic complexes are described and investigated as possible intermediates in the reaction. Mechanistic studies suggest the on‐cycle intermediates do not possess a para‐cymene ligand and that the on‐cycle metalation occurs through an electrophilic attack by the Ru centre. 相似文献
97.
We report the synthesis and characterization of polyphenylated fluorene derivatives and a ring cyclized product containing cyclopenta[def]triphenylene core. Polybromination on fluorene was achieved either by solid state reaction with bromine or utilizing Br2/KBrO3 in AcOH/H2SO4 mixture. The bromofluorenes were converted to the corresponding polyphenylated fluorenes by Suzuki coupling protocol. A hexabromofluorene underwent a multifold Suzuki coupling followed by C–H activation to produce a cyclopenta[def]triphenylene derivative. Fluorene ring showed a severe distortion from planarity beyond tetra-substitution which manifested in the optical properties. 相似文献
98.
P. Karthik Reddy Dilip K. Singh Parameswar K. Iyer 《Polymer Degradation and Stability》2009,94(10):1839-1848
Thermal degradation of Poly (3-hexylthiopene) (P3HT) was studied under nitrogen environment. Kinetic parameters of thermal degradation were determined using Vyazovkin model free method and model fitting method. Vyazovkin model free kinetic analysis is carried out to understand the variation of activation energy (Eα) required for degradation of polymer with conversion (α). Various reaction models have been tested for probable reaction mechanism using hybrid genetic algorithm (HGA). Diffusion model and nucleation & growth with n = 2/3 has prominent role in thermal decomposition of P3HT. A plausible degradation route is proposed based on the experimental details acquired from gas chromatography (GC), Raman spectroscopy, FTIR spectroscopy, powder X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Degradation of P3HT starts at around 195 °C with release of lighter units like CS. Further increase in the temperature results in detachment of the hexyl chain from P3HT and the residue obtained at 1050 °C contains fullerenes mixed with amorphous carbon. 相似文献
99.
Naveen?Kumar?KaliannanEmail authorView authors OrcID profile Karthik?Krishnamurthy 《Journal of nanoparticle research》2017,19(10):346
Monte Carlo simulations were carried out on amorphous titanium dioxide (TiO2) for both bulk and hydroxylated nanoparticles with particle sizes ranging from 1 to 10 nm. The potential developed by the Matsui and Akaogi (MA) was used to model the interatomic interactions of TiO2 in both cases (bulk and nanoparticles). Besides, Angular and Morse potentials proposed by the Tether, Cormack, Du et. al. (TCD) were introduced to model the interactions of hydroxyl groups on the TiO2 surfaces, i.e., the Ti-O-H groups with an experimental and theoretical angles of 125 o . The bulk system was developed using periodic boundary conditions. The TiO2 nanoparticles were extracted by applying a spherical cut section in the bulk TiO2 melt structure to obtain the required size. Free valences on the nanoparticle surfaces were saturated via additional hydroxyl groups and then quenched to 300 K under free boundary conditions. The bulk and surface properties of the nanoparticles were calculated at 300 K and zero pressure and characterized via radial distribution functions, bond angle distributions, bond distances, coordination numbers, OH group concentrations and radial density profiles. In addition, to understand the difference in properties of amorphous hydroxylated TiO2 nanoparticles and bulk amorphous TiO2, a comparative study was done at the same thermodynamic conditions. The study shows that the bulk properties of amorphous hydroxylated TiO2 nanoparticles are strongly size-dependent and different from those of the bulk TiO2. As expected, increasing the particle size leads to an approach of the particle’s bulk properties to the bulk properties of the (quasi) infinite system. The size effects show that decreasing the particle size results in increasing the surface effects and surface OH group concentrations. Accordingly, small-sized TiO2 nanoparticles have higher surface OH group concentrations and larger surface effects than large-sized TiO2 nanoparticles. Larger surface effects result significant changes in their bond angles, bond distances, and coordination numbers. The simulation results of the surface properties reveal that the surface titanium atoms in the TiO2 nanoparticles have the capability of accommodating up to 5 hydroxyl groups. The mean surface hydroxyl group density of the amorphous TiO2 spherical nanoparticles is estimated to be around 8.1/nm 2, which lies in the range of 8–16/nm 2, found by experimental and other simulation studies. Details of the modelling, simulations results and the study are presented in this paper. 相似文献
100.
Kubendran Devaraj Salma Aathika Karthik Periyasamy Premkumar Manickam Periyaraman Shanmugam Palaniyandi 《Natural product research》2019,33(11):1674-1677
A strain of Bacillus amyloliquefaciens KUB29 was identified by 16S ribosomal RNA sequencing (Genbank: MF772779.1). Production of thermostable protease, amylase and lipase were done by the isolated strain. The produced enzymes were partially purified by ammonium precipitation followed by dialysis process. Protease and lipase enzymes are effectively used in bio-oil extraction from proteinaceous sample followed by transesterification to produce methyl ester. Amylase enzyme is widely used in food and laundry industry. The produced enzymes are active at thermophilic condition of 55 °C. Use of these enzymes in biofuel production process will make the process cleaner and greener. 相似文献