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排序方式: 共有148条查询结果,搜索用时 15 毫秒
71.
Govindan RB Vyushin D Bunde A Brenner S Havlin S Schellnhuber HJ 《Physical review letters》2002,89(2):028501
We test the scaling performance of seven leading global climate models by using detrended fluctuation analysis. We analyze temperature records of six representative sites around the globe simulated by the models, for two different scenarios: (i) with greenhouse gas forcing only and (ii) with greenhouse gas plus aerosol forcing. We find that the simulated records for both scenarios fail to reproduce the universal scaling behavior of the observed records and display wide performance differences. The deviations from the scaling behavior are more pronounced in the first scenario, where also the trends are clearly overestimated. 相似文献
72.
Mainak Banerjee Ramesh Karri Kuber Singh Rawat Karthick Muthuvel Dr. Biswarup Pathak Dr. Gouriprasanna Roy 《Angewandte Chemie (International ed. in English)》2015,54(32):9323-9327
Organomercurials including methylmercury are ubiquitous environmental pollutants and highly toxic to humans. Now it could be shown that N‐methylimidazole based thiones/selones having an N‐CH2CH2OH substituent are remarkably effective in detoxifying various organomercurials to produce less toxic HgE (E=S, Se) nanoparticles. Compounds lacking the N‐CH2CH2OH substituent failed to produce HgE nanoparticles upon treatment with organomercurials, suggesting that this moiety plays a crucial role in the detoxification by facilitating the desulfurization and deselenization processes. This novel way of detoxifying organomercurials may lead to the discovery of new compounds to treat patients suffering from methylmercury poisoning. 相似文献
73.
74.
The blood-brain permeation of a structurally diverse set of 281 compounds was modeled using linear regression and a multivariate genetic partial least squares (G/PLS) approach. Key structural features affecting the logarithm of blood-brain partitioning (logBB) were captured through statistically significant quantitative structure-activity relationship (QSAR) models. These relationships reveal the importance of logP, polar surface area, and a variety of electrotopological indices for accurate predictions of logBB. The best models reveal an excellent correlation (r > 0.9) for a training set of 58 compounds. Likewise, the comparison of the average logBB values obtained from an ensemble of QSAR models with experimental values also verifies the statistical quality of the models (r > 0.9). The models provide good agreement (r approximately 0.7) between the predicted logBB values for 34 molecules in the external validation set and the experimental values. To further validate the models for use during the drug discovery process, a prediction set of 181 drugs with reported CNS penetration data was used. A >70% success rate is obtained by using any of the QSAR models in the qualitative prediction for CNS permeable (active) drugs. A lower success rate (approximately 60%) was obtained for the best model for CNS impermeable (inactive) drugs. Combining the predictions obtained from all the models (consensus) did not significantly improve the discrimination of CNS active and CNS inactive molecules. Finally, using the therapeutic classification as a guiding tool, the CNS penetration capability of over 2000 compounds in the Synthline database was estimated. The results were very similar to the smaller set of 181 compounds. 相似文献
75.
V. Karthick V. Shanthi R. Rajasekaran K. Ramanathan 《Applied biochemistry and biotechnology》2012,167(2):237-249
Oseltamivir (Tamiflu) is the preferred anti-viral drug employed to fight the flu virus in infected individuals. The principal target for this drug is a virus surface glycoprotein, neuraminidase (NA), which facilitates the release of nascent virus and thus spreads infections. Until recently, only a low prevalence of neuraminidase inhibitors (NAIs) resistance (<1?%) had been detected in circulating viruses. However, there have been reports of significant numbers of A (H1N1) influenza strains with a H274Y neuraminidase mutation that was highly resistant to the NAI, oseltamivir. In this study, we highlight the effect of point mutation-induced oseltamivir resistance in H1N1 subtype neuraminidases by molecular docking and molecular dynamics simulation approach. Our results suggested that wild-type NA could be more indispensable for the oseltamivir binding, as characterized by minimum number of H-bonds, high flexibility and largest binding affinity than mutant-type NA. This study throws light on the possible effects of drug-resistant mutations on the large functionally important collective motions in biological systems. 相似文献
76.
This article is concerned with a semilinear McKean–Vlasov type stochastic evolution equation in a real Hilbert space. The main goal of the article is to study the existence and uniqueness of mild solutions, Yosida approximations of mild solutions of such equations, and to deduce the weak convergence of the corresponding induced probability measures. As an application, we also study the exponential stability of mild solutions of such equations. 相似文献
77.
Given a Hamiltonian system, one can represent it using a symplectic map. This symplectic map is specified by a set of homogeneous polynomials which are uniquely determined by the Hamiltonian. In this paper, we construct an invariant norm in the space of homogeneous polynomials of a given degree. This norm is a function of parameters characterizing the original Hamiltonian system. Such a norm has several potential applications. 相似文献
78.
Products that are not recycled at the end of their life increasingly damage the environment. In a collection – remanufacturing scheme, these end-of-life products can generate new profits. Designed on the personal computers industry, this study defines an analytical model used to explore the implications of recycling on the reverse supply chain from an efficiency perspective for all participants in the process. The cases considered for analysis are the two- and three-echelon supply chains, where we first look at the decentralized reverse setting followed by the coordinated setting through implementation of revenue sharing contract. We define customer willingness to return obsolete units as a function of the discount offered by the retailer in exchange for recycling devices with a remanufacturing value. The results show that performance measures and total supply chain profits improve through coordination with revenue sharing contracts on both two- and three-echelon reverse supply chains. 相似文献
79.
Masoud Esmaeilikia Behnam Fahimnia Joeseph Sarkis Kannan Govindan Arun Kumar John Mo 《Annals of Operations Research》2016,244(2):407-427
Supply chains (SCs) can be managed at many levels. The use of tactical SC planning models with multiple flexibility options can help manage the usual operations efficiently and effectively, whilst improve the SC resiliency in response to inherent environmental uncertainties. This paper defines tactical SC flexibility and identifies tactical flexibility measures and options for development of flexible SC planning models. A classification of the existing literature of SC planning is introduced that highlights the characteristics of published flexibility inclusive models. Additional classifications from the reviewed literature are presented based on the integration of flexibility options used, solution methods utilized, and real world applications presented. These classifications are helpful for identifying research gaps in the current literature and provide insights for future modeling and research efforts in the field. 相似文献
80.