Langmuir monolayers of a photoisomerizable macrocycle surfactant

An amphiphilic photoisomerizable macrocycle has been prepared that forms stable Langmuir monolayers at the air-water interface. The hydrophilic core of the molecule switches between closed and open isomers upon irradiation by the appropriate wavelengths of light. Isotherm measurements, Brewster angle microscope images, and atomic force micrographs (of transferred Langmuir-Blodgett films) suggest a phase transition between a face-on to a tilted edge-on molecular orientation as a function of surface concentration. In the face-on phase, in situ photoisomerization results in a reversible increase in surface pressure due to greater molecular crowding in the open configuration.     

Examining the lateral displacement of HL60 cells rolling on asymmetric P-selectin patterns

The lateral displacement of cells orthogonal to a flow stream by rolling on asymmetrical receptor patterns presents a new opportunity for the label-free separation and analysis of cells. Understanding the nature of cell rolling trajectories on such substrates is necessary to the engineering of substrates and the design of devices for cell separation and analysis. Here, we investigate the statistical nature of cell rolling and the effect of pattern geometry and flow shear stress on cell rolling trajectories using micrometer-scale patterns of biomolecular receptors with well-defined edges. Leukemic myeloid HL60 cells expressing the PSGL-1 ligand were allowed to flow across a field of patterned lines fabricated using microcontact printing and functionalized with the P-selectin receptor, leveraging both the specific adhesion of this ligand-receptor pair and the asymmetry of the receptor pattern inclination angle with respect to the fluid shear flow direction (α = 5, 10, 15, and 20°). The effects of the fluid shear stress magnitude (τ = 0.5, 1, 1.5, and 2.0 dyn/cm(2)), α, and P-selectin incubation concentration were quantified in terms of the rolling velocity and edge tracking length. Rolling cells tracked along the inclined edges of the patterned lines before detaching and reattaching on another line. The detachment of rolling cells after tracking along the edge was consistent with a Poisson process of history-independent interactions. Increasing the edge inclination angle decreased the edge tracking length in an exponential manner, contrary to the shear stress magnitude and P-selectin incubation concentration, which did not have a significant effect. On the basis of these experimental data, we constructed an empirical model that predicted the occurrence of the maximum lateral displacement at an edge angle of 7.5°. We also used these findings to construct a Monte Carlo simulation for the prediction of rolling trajectories of HL60 cells on P-selectin-patterned substrates with a specified edge inclination angle. The prediction of lateral displacement in the range of 200 μm within a 1 cm separation length supports the feasibility of label-free cell separation via asymmetric receptor patterns in microfluidic devices.     

A Shear Compression Disk Specimen with Controlled Stress Triaxiality under Quasi-Static Loading

This paper introduces a double shear axisymmetric specimen (Shear Compression Disk) and the methodology to extract flow and fracture properties of ductile materials, under various stress triaxiality levels. A thorough numerical investigation of the experimental set-up is performed, which reveals that the stresses are quite uniformly distributed in the gauge section during all the stages of the test. The attainable level of stress triaxiality (with pressures of up to 1.9 GPa) ranges from −0.1 to 1, which can be adjusted by a proper choice of geometrical parameters of the specimen. The methodology is implemented to quasi-static experiments on 4340 Steel and Aluminum 7075-T651 specimens. The flow properties are compared to those obtained by upsetting cylinders and show a very good agreement. For these materials it is observed that, contrary to the fracture strain, the flow properties are quite insensitive to the level of stress triaxiality. The fracture strain of the aluminum alloy increases with triaxiality and may be fitted with an exponential polynomial of the type suggested by [27]. These examples demonstrate the potential of the new specimen to obtain flow and fracture properties of ductile materials under controlled triaxiality.     

Two-sided bounds for the logarithmic capacity of multiple intervals

Potential theory on the complement of a subset of the real axis attracts much attention in both function theory and applied sciences. This paper discusses one aspect of the theory — the logarithmic capacity of closed subsets of the real line. We give simple but precise upper and lower bounds for the logarithmic capacity of multiple intervals and a lower bound valid also for closed sets comprising an infinite number of intervals. Using some known methods to compute the exact values of capacity, we demonstrate graphically how our estimates compare with them. The main machinery behind our results are the separating transformation and dissymmetrization developed by V. N. Dubinin and a version of the latter due to K. Haliste, as well as some classical symmetrization and projection results for the logarithmic capacity. The results of the paper improve some previous achievements by A. Yu. Solynin and K. Shiefermayr.     

Measurement of biomagnetic fields using multichannel superconducting-magnetometer techniques

Summary We have constructed a three-channel differential SQUID magnetometer for the simultaneous measurement of the three orthogonal components of the magnetic field in the same location. The structure of the device is described and MCG data measured are shown. Interference effects between the channels are discussed. A preliminary report of this work has been presented     

Linear expected-time algorithms for connectivity problems

This paper describes fast average-time algorithms for four graph connectivity problems. Algorithms that run in O(n) average time on n-vertex graphs are developed for finding connected components, strong components, and blocks. An O(m)-time algorithm to find a minimum spanning forest in an m-graph is also presented. The analysis of these algorithms uses the random graph model of Erdös and Renyi. All the algorithms are optimum to within a constant factor.     

An analytical-based method for studying the nonlinear evolution of localized vortices in planar homogenous shear flows

Recent experimental and numerical studies have shown that the interaction between a localized vortical disturbance and the shear of an external base flow can lead to the formation of counter-rotating vortex pairs and hairpin vortices that are frequently observed in wall bounded and free turbulent shear flows as well as in subcritical shear flows. In this paper an analytical-based solution method is developed. The method is capable of following (numerically) the evolution of finite-amplitude localized vortical disturbances embedded in shear flows. Due to their localization in space, the surrounding base flow is assumed to have homogeneous shear to leading order. The method can solve in a novel way the interaction between a general family of unbounded planar homogeneous shear flows and any localized disturbance. The solution is carried out using Lagrangian variables in Fourier space which is convenient and enables fast computations. The potential of the method is demonstrated by following the evolved structures of large amplitude disturbances in three canonical base flows, including simple shear, plane stagnation (extensional) and pure rotation flows, and a general case. The results obtained by the current method for plane stagnation and simple shear flows are compared with the published results. The proposed method could be extended to other flows (e.g. geophysical and rotating flows) and to include periodic disturbances as well.     

Log-convexity and log-concavity of hypergeometric-like functions

We find sufficient conditions for log-convexity and log-concavity for the functions of the forms a?∑fkk(a)xk, a?∑fkΓ(a+k)xk and a?∑fkxk/k(a). The most useful examples of such functions are generalized hypergeometric functions. In particular, we generalize the Turán inequality for the confluent hypergeometric function recently proved by Barnard, Gordy and Richards and log-convexity results for the same function recently proved by Baricz. Besides, we establish a reverse inequality which complements naturally the inequality of Barnard, Gordy and Richards. Similar results are established for the Gauss and the generalized hypergeometric functions. A conjecture about monotonicity of a quotient of products of confluent hypergeometric functions is made.