The sound velocity in ideal liquid mixtures from thermal volume fluctuations.

The selection of the correct mixing rule for sound velocity in ideal liquid mixtures determines the interpretation of the sound velocity in real mixtures. This is especially important for the determination of apparent properties of solutes, such as their apparent compressibility. There are different approaches reported in the literature, and this article presents a new derivation of the mixing rule based on statistical mechanics. It is shown that the correlation of volume fluctuations between adjacent components has a crucial influence on the ideal mixing rule.     

Fast simultaneous LC/MS/MS determination of 10 active compounds in human serum for therapeutic drug monitoring in psychiatric medication

A UPLC/MS/MS method with simple protein precipitation has been validated for the fast simultaneous analysis of agomelatine, asenapine, amisulpride, iloperidone, zotepine, melperone, ziprasidone, vilazodone, aripiprazole and its metabolite dehydro‐aripiprazole in human serum. Alprenolol was applied as an internal standard. A BEH C₁₈ (2.1 × 50 mm, 1.7 µm) column provided chromatographic separation of analytes using a binary mobile phase gradient (A, 2 mmol/L ammonium acetate, 0.1% formic acid in 5% acetonitrile, v/v/v; B, 2 mmol/L ammonium acetate, 0.1% formic acid in 95% acetonitrile, v/v/v). Mass spectrometric detection was performed in the positive electrospray ionization mode and ion suppression owing to matrix effects was evaluated. The validation criteria were determined: linearity, precision, accuracy, recovery, limit of detection, limit of quantification, reproducibility and matrix effect. The concentration range was as follows: 0.25–1000 ng/mL for agomelatine; 0.25–100 ng/mL for asenapine and iloperidone; 2.5–1000 ng/mL for amisulpride, aripiprazole, vilazodone and zotepine; 2.3–924.6 ng/mL for dehydroaripiprazole; 2.2–878.4 ng/mL for melperone; and 2.2–883.5 ng/mL for ziprasidone. Limits of quantitation below a therapeutic reference range were achieved for all analytes. Intra‐run precision of 0.4–5.5 %, inter‐run precision of 0.6–8.2% and overall recovery of 87.9–114.1% were obtained. The validated method was successfully implemented into routine practice for therapeutic drug monitoring in our hospital. Copyright © 2015 John Wiley & Sons, Ltd.     

Novel synthetic approach to alfaprostol key intermediates via Stille coupling with an alkyne

Novel intermediates based on the Corey skeleton for preparation of the ω-chain of non-halogenated unnatural prostaglandin analogues containing a triple bond at position 13–14 (PG numbering) were synthesized. The utilization of a novel synthetic approach towards a new tin intermediate, and subsequent Stille coupling opens up new possibilities for preparing these important pharmaceutical intermediates.     

Multiobjective PDE-constrained optimization using the reduced-basis method

In this paper the reduced basis (RB) method is applied to solve quadratic multiobjective optimal control problems governed by linear parametrized variational equations. These problems often arise in applications, where the quality of the system behavior has to be measured by more than one criterium. The weighted sum method is exploited for defining scalar-valued linear-quadratic optimal control problems built by introducing additional optimization parameters. The optimal controls corresponding to specific choices of the optimization parameters are efficiently computed by the RB method. The accuracy is guaranteed by an a-posteriori error estimate. An effective sensitivity analysis allows to further reduce the computational times for identifying a suitable and representative set of optimal controls.     

Determination of arsenic at a gold-plated carbon paste electrode using constant current stripping analysis

A new stripping method for the determination of arsenic in water samples with a gold film-plated carbon paste electrode has been developed for the use in constant current stripping analysis (CCSA). In the novelized procedure, differentiation between As(III) and chemically pre-reduced As(V), the effect of Cu(II) on the response of arsenic, and the stability of sample solutions were studied in detail. Compared to the voltammetric approach, the method utilizing CCSA offers a more rapid procedure with improved analytical characteristics such as reproducibility, selectivity over the Cu(II) ions, or lower detection limit (3 ppb for As(III) and 0.5 ppb for As(V), respectively). The possibilities of the optimized method are demonstrated by determinations of As(III), As(V), and total arsenic in samples of polluted river water.     

The effect of influential data, model and method on the precision of univariate calibration

Building a calibration model with detection and quantification capabilities is identical to the task of building a regression model. Although commonly used by analysts, an application of the calibration model requires at first careful attention to the three components of the regression triplet (data, model, method), examining (a) the data quality of the proposed model; (b) the model quality; (c) the LS method to be used or a fulfillment of all least-squares assumptions. This paper summarizes these components, describes the effects of deviations from assumptions and considers the correction of such deviations: identifying influential points is the first step in least-squares model building, the calibration task depends on the regression model used, and finally the least squares LS method is based on assumptions of normality of errors, homoscedasticity, independence of errors, overly influential data points and independent variables being subject to error. When some assumptions are violated, the ordinary LS is inconvenient and robust M-estimates with the iterative method of reweighted least-squares must be used. The effects of influential points, heteroscedasticity and non-normality on the calibration precision limits are also elucidated. This paper also considers the proper construction of the statistical uncertainty expressed as confidence limits predicting an unknown concentration (or amount) value, and its dependence on the regression triplet. The authors' objectives were to provide a thorough treatment that includes pertinent references, consistent nomeclature, and related mathematical formulae to show by theory and illustrative examples those approaches best suited to typical problems in analytical chemistry. Two new algorithms, calibration and linear regression written in s-plus and enabling regression triplet analysis, the estimation of calibration precision limits, critical levels, detection limits and quantification limits with the statistical uncertainty of unknown concentrations, form the goal of this paper.     

On the stereochemistry of photoaddition between α,β-unsaturated ketones and olefins. III.

The α,β-unsaturated ketone $\text{1}$ yields with allene the photocycloadduct $\text{3}$ predicted by our empirical photoaddition rule and the byproduct 7. The formation of this material may be rationalized by the sequence $\text{1}$ → $\text{4}$ → $\text{5}$ → $\text{6}$ → $\text{7}$. The isomeric ketone $\text{2}$ is unreactive under the same conditions, since α addition is prohibited by the rule and β addition is severely blocked.     

Determination of some pharmaceuticals using simple potentiometric sensors of coated-wire type

Summary The preparation of simple potentiometric sensors of the coated-wire type is described and working instructions for their use are given. The sensors prepared from an ordinary aluminium conductor, being simple and cheap, can well serve to monitore the titrations based on ion-pair formation. The application possibilities are discussed and shown as practical examples on analyses of nasal and eye drops containing cationic surfactants or salts of alkaloids.

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Bestimmung einiger Arzneimittel mit Hilfe einfacher potentiometrischer Sensoren

Zusammenfassung Die Herstellung einfacher potentiometrischer Sensoren mit isoliertem Draht und deren Verwendung wurde beschrieben. Aus einfachem Aluminiumdraht sind sie billig und können für Titrationen auf der Grundlage von Ionenpaar-Bildung dienen. Die Möglichkeiten ihrer Anwendung wurden erörtert und praktiziert für die Untersuchung von Nasen- und Augentropfen mit kationischen Schaumbildnern oder von Alkaloidsalzen.

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According to the Poster XII-23 presented at Euroanalysis V, Cracow, August 1984; the comments inserted into the text are a consequence of the discussion.