全文获取类型
收费全文 | 295篇 |
免费 | 15篇 |
专业分类
化学 | 263篇 |
晶体学 | 1篇 |
力学 | 3篇 |
数学 | 7篇 |
物理学 | 36篇 |
出版年
2023年 | 5篇 |
2022年 | 10篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 19篇 |
2018年 | 8篇 |
2017年 | 8篇 |
2016年 | 15篇 |
2015年 | 12篇 |
2014年 | 11篇 |
2013年 | 15篇 |
2012年 | 19篇 |
2011年 | 21篇 |
2010年 | 20篇 |
2009年 | 7篇 |
2008年 | 18篇 |
2007年 | 17篇 |
2006年 | 21篇 |
2005年 | 12篇 |
2004年 | 14篇 |
2003年 | 13篇 |
2002年 | 6篇 |
2001年 | 4篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有310条查询结果,搜索用时 15 毫秒
81.
Sano H Noguchi T Tanatani A Miyachi H Hashimoto Y 《Chemical & pharmaceutical bulletin》2004,52(8):1021-1022
Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated. 相似文献
82.
Strange W Bohn OS Trent SA Nishi K 《The Journal of the Acoustical Society of America》2004,115(4):1791-1807
Current theories of cross-language speech perception claim that patterns of perceptual assimilation of non-native segments to native categories predict relative difficulties in learning to perceive (and produce) non-native phones. Cross-language spectral similarity of North German (NG) and American English (AE) vowels produced in isolated hVC(a) (di)syllables (study 1) and in hVC syllables embedded in a short sentence (study 2) was determined by discriminant analyses, to examine the extent to which acoustic similarity was predictive of perceptual similarity patterns. The perceptual assimilation of NG vowels to native AE vowel categories by AE listeners with no German language experience was then assessed directly. Both studies showed that acoustic similarity of AE and NG vowels did not always predict perceptual similarity, especially for "new" NG front rounded vowels and for "similar" NG front and back mid and mid-low vowels. Both acoustic and perceptual similarity of NG and AE vowels varied as a function of the prosodic context, although vowel duration differences did not affect perceptual assimilation patterns. When duration and spectral similarity were in conflict, AE listeners assimilated vowels on the basis of spectral similarity in both prosodic contexts. 相似文献
83.
We propose an optical system to implement rewritable transparent broad-band color filters. The filter consists of a linear variable filter and a liquid crystal spatial light modulator in which an expected filter function is written. A time-integrated intensity image was taken while the filter was passing the lens aperture of a CCD camera. The averaged norm error between the implemented and the expected filter functions was about 5.4#x0025;. The system was applied to spectral estimation in a two-dimensional color image. 相似文献
84.
85.
Hirohmi Watanabe Aya Fujimoto Atsushi Takahara 《Journal of polymer science. Part A, Polymer chemistry》2013,51(17):3688-3692
Urushi (oriental lacquer) is made from the sap of Rhus vernicifera and consists mainly of the catechol derivative urushiol. Thermal curing of urushiol, unlike other catechol derivatives, is possible because of the unsaturated double bonds in the long hydrocarbon side chain. We described here a simple, efficient method to produce a thermally cross‐linked urushi thin film using iron(II) acetate as the additive. The cured thin films showed robust, flexible feature as confirmed by strain‐induced elastic buckling instability for mechanical measurements (SIEBIMM) and bulging experiments. In contrast, a thin film of poly(dopamine) that is a typical catechol derivative without long hydrocarbon side chain showed brittleness. The long hydrocarbon side chain of urushiol plays an important role for both thermal processability and superior mechanical properties of the material. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3688–3692 相似文献
86.
Aya Hashimoto Liang‐da Chiu Keigo Sawada Tomohiko Ikeuchi Katsumasa Fujita Masahide Takedachi Yoshinori Yamaguchi Satoshi Kawata Shinya Murakami Eiichi Tamiya 《Journal of Raman spectroscopy : JRS》2014,45(2):157-161
Hydroxyapatite (HA) is synthesized at early stages of bone formation by osteoblasts. Nondestructive observation of early stages of osteoblastic mineralization provides crucial information for biological mechanism of bone formation. Raman microscopy serves as an ideal tool to observe the osteoblastic mineralization process because it shows the chemical information of the sample at a minimally invasive level. In addition, HA is a marker for osteoblastic mineralization, and HA Raman signal is strong enough to identify mineralized spots in osteoblasts. In this research, we visualized the distribution of HA in cultured mouse osteoblasts by Raman imaging and observed the location of the mineralized spots in the culture. We monitored HA Raman signal from osteoblast culture for 3 days after administrating the osteogenic differentiation medium and observed Raman signal associated with HA. We identified mineralized spots of KUSA‐A1 by Raman imaging constructed from the distribution of HA Raman signal. We successfully visualized the distribution of the mineralized spots in the culture of KUSA‐A1. We compared our Raman images with Alizarin red S staining assay, which was a conventional method to evaluate the mineralization process. Raman imaging of the KUSA‐A1 culture visualized the mineralized spots more accurately than Alizarin red S staining assay. Raman imaging of HA serves as a powerful tool to identify the mineralized spots in an in vitro culture of osteogenic lineage cells. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
87.
Kojima A Mabuchi Y Konishi M Okihara R Nagano M Akizawa T 《Chemical & pharmaceutical bulletin》2011,59(8):965-971
The structural conversion of the prion protein (PrP) from the normal cellular isoform (PrP(C)) to the posttranslationally modified form (PrP(Sc)) is thought to relate to Cu2? binding to histidine (H) residues. Traditionally, the binding of metals to PrP has been investigated by monitoring the conformational conversion using circular dichroism (CD). In this study, the metal-binding ability of 21 synthetic peptides representing regions of human PrP(C) was investigated by column switch high-performance liquid chromatography (CS-HPLC). The CS-HPLC system is composed of a metal chelate affinity column and an octadecylsilica (ODS) reversed-phase column that together enable the identification of metal-binding regardless of conformational conversion. Synthetic peptides were designed with respect to the position of H residues as well as the secondary structure of human PrP (hPrP). The ability of the octapeptide (PHGGGWGQ)-repeating region (OP-repeat) to bind metals was analyzed by CS-HPLC and supported by CD analysis, and indicated that CS-HPLC is a reliable and useful method for measuring peptide metal-binding. Peptides from the middle region of hPrP showed a high affinity for Cu2?, but binding to Zn2?, Ni2?, and Co2? was dependent on peptide length. C-Terminal peptides had a lower affinity for Cu2?, Zn2?, Ni2?, and Co2? than OP-repeat region peptides. Interestingly, hPrP193-230, which contained no H residues, also bound to Cu2?, Zn2?, Ni2?, and Co2?, indicating that this region is a novel metal-binding site in the C-terminal region of PrP(C). The CS-HPLC method described in this study is useful and convenient for assessing metal-binding affinity and characterizing metal-binding peptides or proteins. 相似文献
88.
Hiroko Nakayama Kanae Hata Izumi Matsuoka Liqing Zang Youngil Kim Djongchi Chu Lekh Raj Juneja Norihiro Nishimura Yasuhito Shimada 《Molecules (Basel, Switzerland)》2020,25(24)
(1) Background: The obesity epidemic has been drastically progressing in both children and adults worldwide. Pharmacotherapy is considered necessary for its treatment. However, many anti-obesity drugs have been withdrawn from the market due to their adverse effects. Instead, natural products (NPs) have been studied as a source for drug discovery for obesity, with the goal of limiting the adverse effects. Zebrafish are ideal model animals for in vivo testing of anti-obesity NPs, and disease models of several types of obesity have been developed. However, the evidence for zebrafish as an anti-obesity drug screening model are still limited. (2) Methods: We performed anti-adipogenic testing using the juvenile zebrafish obesogenic test (ZOT) and mouse 3T3-L1 preadipocytes using the focused NP library containing 38 NPs and compared their results. (3) Results: Seven and eleven NPs reduced lipid accumulation in zebrafish visceral fat tissues and mouse adipocytes, respectively. Of these, five NPs suppressed lipid accumulation in both zebrafish and 3T3-L1 adipocytes. We confirmed that these five NPs (globin-digested peptides, green tea extract, red pepper extract, nobiletin, and Moringa leaf powder) exerted anti-obesity effects in diet-induced obese adult zebrafish. (4) Conclusions: ZOT using juvenile fish can be a high-throughput alternative to ZOT using adult zebrafish and can be applied for in vivo screening to discover novel therapeutics for visceral obesity and potentially also other disorders. 相似文献
89.
Kanae Hayashi Yoshinori Tanaka Seizo Okamura 《Journal of polymer science. Part A, Polymer chemistry》1981,19(6):1435-1443
Bulk butadiene was polymerized by a cationic mechanism in a wide dose rate range. The M?n of the product was about 2300, independent of dose rate. The polymer had 83% residual unsaturation and the remaining double bond was 77% trans and 23% vinyl and had no cis unit. When the polymer yield exceeded 10% gel was formed, but the value of the residual unsaturation in the polymer remained unchanged. This indicated a mechanism that correlated propagation, cyclization, and crosslinking reactions with a cationic intermediate. 相似文献
90.
The mechanism of the solvent extraction of cytochrome c (Cyt c) via reverse micelle formation was studied from an electrochemical point of view. Potentiometric measurements showed that the Galvani potential difference of the oil/water (O/W) interface played a crucial role in the spontaneous extraction of Cyt c with bis(2-ethylhexyl)sulfosuccinate (AOT). However, the dependence of the extraction efficiency on the concentration of an aqueous electrolyte (KCl) could be explained not by the effect of the interfacial potential, but by the change in the interfacial tension (gamma). Electrocapillary measurements showed that the adsorption of AOT anions to the O/W interface resulted in a significant decrease of gamma in a higher potential range, where reverse micelles were formed. The bottom level of gamma in the higher potential range was increased with [KCl]. The lower extraction efficiency for higher [KCl]'s was elucidated by a "size exclusion effect". This was also supported by water-content measurements by the Karl Fisher method. 相似文献