Mimicking nature synthetically : The successful development of multistep stereoselective syntheses gives access to natural product inspired compound collections having carbo‐, oxa‐,and azacyclic scaffold structures which promise to provide sources for new reagents in medicinal chemistry and chemical biology research.
Enhancement of skin permeability of salicylate from non-aqueous vehicle by ion-pair formation with either alkylamines or benzylamine as model cationic ions was examined in excised guinea pig dorsal skin. Solubility of salicylate in isopropyl myristate (IPM) was increased by the addition of either alkylamines or benzylamine as counter ions. The increase was more significant in the presence of amines with longer alkyl chains. Flux of salicylate increased in the presence of these amines due to the increase in the solubility. Maximum flux was observed in the presence of n-hexylamine, which induced an 11-fold increase due to 137-fold increase in solubility. Flux and permeability coefficients of salicylate in the presence of n-butylamine, n-hexylamine, iso-octylamine and benzylamine as counter ions in IPM were larger than those of the non-ionic form of salicylic acid. Flux of 3-methylsalicylate (3-CH3 substituent) and that of 5-hydroxysalicylate (5-OH substituent) were smaller than that of salicylate in the presence of n-hexylamine. After partition to the skin surface, the ion-pair is suggested to dissociate and permeate separately according to the study using lidocaine as the counter ion. Flux of salicylate increased in the presence of benzylamine as the counter ion by the addition of 15% ethanol and 15% ethanol plus 1% l-menthol due to further improvement in the solubility as well as an increase in the permeability coefficient. 相似文献
2,3,3‐Trimethylindolenine and 5‐chloro‐2,3,3‐trimethylindolenine were converted into β‐diformyl compounds by the action of the Vilsmeier reagent at 50°C. The dialdehydes reacted with various arylhydrazines and 2‐pyridylhydrazine to produce mono‐hydrazones as mixtures of cis and trans isomers. Heating the hydrazones in refluxing ethanol produced 3,3‐dimethyl‐2‐(1‐aryl‐1H‐pyrazol‐4‐yl)‐3H‐indoles in excellent yields. Reaction of the β‐diformyl compounds with hydrazine itself led directly to 3,3‐dimethyl‐2‐(pyrazol‐4‐yl)‐3H‐indoles. 相似文献
The emergence of dynamical abrupt transitions for the first time in an ensemble of identical limit-cycle and chaotic oscillators coupled via a common environment is reported. The transition from the oscillatory state to the death state and vice versa, in these networks of oscillators are found not only discontinuous as well as irreversible in the parameter space. This first order phase transition in these systems is termed as Explosive Death. The occurrence of such transition is studied in details by using an appropriate order parameter for both limit-cycle and chaotic oscillators, in particular, Stuart–Landau and Rössler oscillators. The backward transition point for this phenomenon is obtained analytically using linear stability analysis and is found to be consistent with the numerical results. 相似文献
A holistic and comparative quality assessment of vinegars from different countries is needed with international trade of vinegar become frequent. In this study, compounds characterization and comparison of commercial‐grade Chinese cereal and European grape vinegars were performed using 1H NMR spectroscopy coupled with principal component analysis (PCA) and orthogonal projection to latent structures discriminate analysis (OPLS‐DA). The results showed that Balsamic vinegars of Modena were clearly discriminated by higher amount of fructose and glucose, while Chinese aromatic vinegar and aged vinegars were characterized by higher amount of amino acids, volatile compounds, succinate and betaine. On the other hand, flavoring compounds in Chinese rice vinegar and European wine vinegars are less than the others. These characteristic components are associated with the special raw materials and producing process of each types of vinegar and endow them special flavor. The results obtained in this study provide a global insight into vinegar through a 1H NMR based compounds analysis that allows a holistic quality assessment and comparison of vinegars from different manufacture origins. 相似文献
An efficient synthesis of novel benzo[f]Chromeno[2,3-d]pyrimidine and unknown benzo[f]chromeno[2,3-d][1,2,4]triazolopyrimidine derivatives is described utilizing ethyl-2-amino-4-phenyl-4H-benzo[f]chromene-3-carboxylate as precursor via aza-Wittig reaction. The process proved to be simple, high-yielding, and efficient. 相似文献
Nuclear effects in deep inelastic scattering at low $x$ are phenomenologically described changing the typical dynamical and/or kinematical scales characterizing the free nucleon case. In a holographic approach, this rescaling is an analytical property of the computed structure function $F_2(x,Q^2)$. This function is given by the sum of a conformal term and of a contribution due to quark confinement, depending on IR hard-wall parameter $z_0$ and on the mean square distances, related to a parameter $Q^\prime $, among quarks and gluons in the target. The holographic structure function per nucleon in a nucleus $A$ is evaluated showing that a rescaling of the typical nucleon size, $z_0$ and $Q^\prime $, due to nuclear binding, can be reabsorbed in a $Q^2$-rescaling scheme. The difference between neutron and proton structure functions and the effects of the longitudinal structure functions can also be taken into account. The obtained theoretical results favorably compare with the experimental data. 相似文献
Multiferroic materials: A novel class of multiferroics based on organic-inorganic hybrid materials is synthesized. The ferromagnetic properties originate from the coordination network, whereas the ferroelectricity results from the polar organic ions (see picture, M=magnetization and P=polarization). 相似文献