Temperature and concentration dependences of density and refraction of aqueous duloxetine solutions

Present paper reports the measured densities (ρ) and refractive indices (n _D) of aqueous solutions of Duloxetine drug in wide range of molal concentrations (m = 0.0101–0.1031 mol kg^?1) and at different temperatures (297.15, 302.15, and 307.15 K). Apparent molar volumes (φ_v) of drug were calculated from density data and fitted to Masson’s relation \((\phi _\nu = \phi _\nu ^0 + S_\nu ^* \sqrt c )\) and partial molar volumes (φ _v ⁰ ) were evaluated at different temperatures. Concentration dependence of refractive index (n _D = Kc + n _D ⁰ ) at experimental temperature has been studied. Density and refractive index data has been used for the calculation of specific refractions (R _D). Experimental (ρ and n _D) and calculated (φ_v, φ _v ⁰ , and R _D) properties have been interpreted in terms of concentration and temperature effects on structural fittings and drug-water interactions.     

Refractivity and polarizability of mixtures of L-histidine–metformin hydrochloride–water at 30°C

The molar refractivity and polarizability of mixtures of L-histidine (0.01–0.11 mol L^–1)–metformin hydrochloride (0.03, 0.05, 0.07 mol L^–1)–water were calculated from density and refractive index data at 30°C. Enhancement in the polarizability has been observed with increase in L-histidine concentration as well as metformin hydrochloride content in the solution. The molar refractivity and polarizability of solutions increased appreciably after 0.09 mol L^–1 L-histidine in each aqueous solution.     

The density and viscosity of aqueous solutions of sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide and solute-solvent molecular interactions study

This paper reports the measured density and viscosity of aqueous solutions of different concentrations of antiulcer drug, sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide at 40°C. The apparent molar volumes of different solutions were computed using density data. Apparent molar volume at infinite dilution which reflects solute-solvent interaction and S _v, the parameter that represents solute-solute interaction has been determined graphically by using Masson’s equation. Viscosity data has been analyzed by Jone-Dole equation. Viscosity coefficients A and B were determined and explained in terms of solute-solute, solute-solvent interactions and structure making/breaking ability of said drug.     

Discussion on a possible neutrino detector located in India

We have identified some important and worthwhile physics opportunities with a possible neutrino detector located in India. Particular emphasis is placed on the geographical advantage with a stress on the complimentary aspects with respect to other neutrino detectors already in operation.     

Solution behavior of metoclopramide in aqueous-alcoholic solutions at 30°C

Densities (ρ) and refractive indices (n_D) of solutions of antiemetic drug metoclopramide (4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride hydrate) in methanolwater and ethanol-water mixtures of different compositions were measured at 30°C. Apparent molar volume (φ_v) of the drug was calculated from density data and partial molar volumes (φ_v⁰) were determined from Massons relation. Concentration dependence of nD has been studied to determine refractive indices of solution at infinite dilution (n_D⁰). Results have been interpreted in terms of solute-solvent interactions.