Effect of Dissolved Oxygen on the Reduction of Stable Nitroxide by Ascorbic Acid: In Vitro Model for Acute Hypoxia Ischemia

The reaction between 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (PCAM), which is a blood–brain-barrier (BBB) permeable stable cyclic nitroxide, and ascorbic acid was examined in a low dissolved oxygen-phosphate buffer (low DO-PB, 0.1 mM DO) under 8% oxygen in a glove bag or in an ordinal dissolved oxygen-phosphate buffer (ordinal DO-PB, 0.3 mM DO) under 21% oxygen in an open atmosphere with and without diethylenetriaminepentaacetic acid (DTPA). In PB with DTPA, no difference was observed between the results in the low DO-PB and those in the ordinal DO-PB. In the ordinal DO-PB without DTPA, the rate constant of the PCAM decrease was half that in the low DO-PB without DTPA. The present results indicate that high DO and coexisting transition metal ions caused the oxidation of ascorbic acid, which degraded the PCAM reduction. The stable nitroxide-ascorbic acid system without DTPA was found to be applicable to an in vitro model for the acute hypoxia ischemia.     

Passively Q-switched GdVO<Subscript>4</Subscript>/Nd:GdVO<Subscript>4</Subscript> laser with Cr<Superscript>4+</Superscript>:YAG saturable absorber under direct 879 nm diode pumping to the emitting level

A passively Q-switched 1.06 μm laser with Cr⁴⁺:YAG saturable absorber by direct 879 nm diode pumping grown-together composite GdVO₄/Nd:GdVO₄ crystal to the emitting level was demonstrated in this paper. The characteristics of pulsed laser were investigated by using two kinds of Cr⁴⁺:YAG crystal with the initial transmissivity of 80 and 90%, respectively. When the T ₀ = 90% Cr⁴⁺:YAG was used, an average output power of 1.59 W was achieved at an incident pump power of 10 W. The pulse width and repetition rate were 64.5 ns and 170 kHz, respectively. The thermal lens effect of laser crystal was analyzed.     

Q-switched Ho:YAlO<Subscript>3</Subscript> laser pumped by Tm:YLF laser at room temperature

A Q-switched high efficient Ho:YAlO₃ (Ho:YAP) laser pumped by a diode-pumped Tm:YLF laser at room-temperature is realized. The maximum output energy reaches 1.58 mJ under the repetition frequency of 5 kHz, when the incident pump power is 15.6 W. The pulse width is 22 ns. The wavelength is 2118 nm when the transmission of output coupler is 30%. The beam quality factor is M ² ∼ 1.39 measured by the traveling knife-edge method.     

Efficient and wavelength-tunable anti-Stokes frequency conversion with good beam quality in the fundamental mode of photonic crystal fiber

Using the photonic crystal fiber (PCF) with the zero dispersion wavelength of 848 nm for the fundamental mode, the efficient anti-Stokes signal generations from 645 to 543 nm are realized by pumping in the normal dispersion region. When the pump average power increases from 200 to 500 mW, the output power of the anti-Stokes signal increases 8.46 times, the power ratio of the anti-Stokes signal at 543 nm to the residual pump is calculated as 22.6:1, and the conversion efficiency η in the experiment can be up to 46%. Moreover, good optical beam quality of the anti-Stokes signal can be achieved.     

In-band pumped Er:YAG ceramic laser with 11 W of output power at 1645 nm

We report on a high power polycrystalline Er:YAG ceramic laser in-band pumped by a cladding-pumped Er, Yb fiber laser wavelength locked at 1532 nm with a volume Bragg grating. Using 1.0 at % Er³⁺-doped ceramic as the gain medium and an output coupler of 10% transmission, the laser had a threshold pump power of ∼1.5 W and generated 11 W of continuous-wave output at 1645 nm for 23.3 W of incident pump power at 1532 nm, corresponding to a slope efficiency with respect to incident pump power of 51%.     

Diode-pumped Pr<Superscript>3+</Superscript>:YAlO<Subscript>3</Subscript>/LBO violet laser at 374 nm

We report a diode-pumped Pr³⁺:YAlO₃ laser emitting at 747 nm. A power of 232 mW at 747 nm has been achieved in continuous-wave operation with a diode emitting 2 W at 448 nm. Furthermore, intracavity second-harmonic generation in continuous-wave mode has also been demonstrated with a power of 52 mW at 374 nm by using a LBO nonlinear crystal. The fluctuation of the violet output power was better than 2.3%. The beam quality M ² value is 2.2.     

Switchable multiple lasing oscillations in an erbium-doped fiber ring laser using a single stage of a Sagnac loop mirror

A simple scheme for a switchable multi-wavelength erbium-doped fiber (EDF) ring laser is investigated by using a single stage of a Sagnac loop mirror. The multiple lasing outputs are obtained and switched readily by controlling the state of polarization (SOP). Since the transmission characteristics of the Sagnac loop mirror in terms of peak wavelengths and peak powers strongly depend on the SOP, the switching performance of the proposed multi-wavelength EDF laser can be effectively obtained. The proposed multi-wavelength EDF laser has versatile lasing outputs in states of a single-, dual-, triple-, and quadruple-wavelength oscillations. The multiple outputs are effectively switchable by adjusting the SOP.     

Effect of metallic and hyperbolic metamaterial surfaces on electric and magnetic dipole emission transitions

Spontaneous emission patterns of electric and magnetic dipoles on different metallic surfaces and a hyperbolic metamaterial (HMM) surface were simulated using the dyadic Green’s function technique. The theoretical approach was verified by experimental results obtained by measuring angular-dependent emission spectra of europium ions on top of different films. The results show the modified behavior of electric and magnetic dipoles on metallic and HMM surfaces. The results of numerical calculations agree well with experimental data.     

High repetition rate LiF<Stack><Subscript>2</Subscript><Superscript>−</Superscript></Stack>: Color center laser

The efficient oscillation of LiF:F₂⁻ color center laser pumped by a compact LD-pumped Nd:YVO₄ acousto optically Q-switched laser with 30 kHz pulse repetition rate was demonstrated. The broadband oscillation with 75 μJ pulse energy and 37 kW peak power with the slope efficiency 20% was obtained. The average output power as high as 230 mW was reached. The narrow line tunable from 1.10 to 1.29 μm laser radiation with 10% conversion efficiency in the maximum of the tuning curve was achieved under pumping with 1.6 W average pump power.     

Efficient and compact intracavity-frequency-doubled Nd:LuVO<Subscript>4</Subscript>/LBO laser at 538 nm end-pumped by a fiber-coupled laser diode

We report a diode-pumped Nd:LuVO₄ laser emitting at 1076 nm, based on the ⁴ F _3/2−⁴ I _11/2 transition, generally used for a 1066 nm emission. A power of 689 mW at 1076 nm has been achieved in continuous-wave (CW) operation with a fiber-coupled laser diode emitting 17.8 W at 809 nm. Intracavity second-harmonic generation (SHG) in CW mode has also been demonstrated with a power of 105 mW at 538 nm by using a LiB₃O₅ (LBO) nonlinear crystal.