1,4-戊二烯-3-酮肟醚类化合物的合成及生物活性

将1,4-戊二烯-3-酮结构中的羰基转变为肟醚基团,合成了7个1,4-戊二烯-3-酮肟醚类化合物,其结构经1H NMR、13C NMR、IR和ESI-MS表征。生物活性测试结果表明,在药剂浓度为500mg/L时,化合物4c、4f和4g对烟草花叶病毒(TMV)在治疗作用方面的抑制率为49.6%、53.6%和47.4%,与病毒唑(45.2%)相当;化合物4b、4c、4f和4g对TMV在保护作用方面的抑制率分别为57.2%、58.4%、58.9%和59.0%,稍低于病毒唑(61.8%);化合物4a、4b、4c和4g对TMV在钝化作用方面的抑制率分别为95.5%、92.6%、95.0%和89.5%,优于对照药病毒唑(87.9%)。这些结果表明,1,4-戊二烯-3-酮肟醚类化合物对植物病毒表现有良好抑制作用,在其结构基础上进行适当的优化,有望得到具有良好抗植物病毒活性的先导化合物。     

金@氧缺陷二氧化钛核壳纳米颗粒的制备及光催化产氢

通过水解TiCl_3在金纳米颗粒外表生长TiO_2,然后在Ar/H2气氛中高温煅烧成功地合成了核壳形貌的Au@H-TiO_2缺陷结构。采用XRD、TEM、XPS、UV-Vis测试方法对产物的物相结构、形貌及光吸收能力做了系统的分析。与不存在缺陷态的TiO_2和Au@A-TiO_2相比,Au@H-TiO_2表现出最高的产氢速率,这可以归因于其电荷分离效率的提高和电荷转移阻抗的降低,瞬态光电流测试以及电化学阻抗数据证实了这一结论。这些性能的改进可能与Au@H-TiO_2中的Ti~(3+)自掺杂和Au修饰有关。     

岩爆与围岩分类

岩爆是高地应力条件下完整脆性硬质围岩失稳的一种表现型式,岩爆烈度如何影响围岩类别尚不清楚,探索岩爆与围岩分类的关系,对准确判别高地应力条件下的围岩类别有着重要意义。本文以某深埋隧洞围岩分类为依据,对我国水利水电地下洞室围岩分类中岩爆烈度与围岩类别的关系、岩爆判别指标的选取等问题进行了探讨。     

基于复杂网络上的演化博弈

论述了基于复杂网络的演化博弈.通过介绍相应的演化博弈模型-囚徒困境模型以及一些复杂网络,鉴于复杂网络的优点以及博弈演化的特性,将两者巧妙的结合起来,介绍了研究这类问题的一些方法.     

强并半格中的C-滤子及其应用

首先,在并半格中引入了上覆盖关系的概念以及由上覆盖关系确定的强并半格中的上覆盖概念,在强并半格中讨论了它们的基本性质;其次,通过上覆盖概念在强并半格中引入了C-滤子概念,证明了强并半格中的C-滤子是通常滤子,但强并半格中的通常滤子并非C-滤子;最后,研究了强并半格同态和余Frame同态之间的关系,证明了余Frame S与相应的C_S-滤子型余Frame之间的同构定理.     

Coumarinolignans Isolated from the Seeds of Brucea javanica

A new coumarinolignan, cleomiscosin E ( 1 ), together with the known compound cleomiscosin A ( 2 ), has been isolated from the seeds of Brucea javanica (L.) Merr . Their structures were assigned on the basis of spectral studies. These two compounds exhibited potent anti‐inflammatory activities by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated RAW264.7 macrophages.     

Synthesis, structure and magnetism of a S-shaped multi-iron substituted arsenotungstate containing a trivacant Keggin [B-α-AsW9O34] and a hexavacant Keggin [α-AsW6O26] fragments

A S-shaped multi-iron substituted arsenotungstate [enH₂]₂[(α-H₂As^VW₆O₂₆)Fe₃(H₂O)(B-α-H₄As^VW₉O₃₄)]₂[Fe]₂·8H₂O (1) (en=ethylenediamine) has been prepared by reaction of K₁₄[As₂^IIIW₁₉O₆₇(H₂O)]·nH₂O with Fe₂(SO₄)₃·xH₂O under hydrothermal conditions and structurally characterized by elemental analyses, IR spectra, UV spectra, powder X-ray diffraction (PXRD) and single-crystal X-ray diffraction. The skeleton of 1 consists of two asymmetric sandwich-type subunits [(α-H₂As^VW₆O₂₆)Fe₃(H₂O)(B-α-H₄As^VW₉O₃₄)]⁵⁻ linked by a di-Fe^III cluster. Moreover, magnetic susceptibility measurements demonstrate that 1 indicates the antiferromagnetic coupling interactions within Fe^III centers with the best-fitting set of parameters of J₁=−7.07 cm⁻¹, J₂=−0.45 cm⁻¹ and g=2.05, which are generated by the addition of the expressions of the molar susceptibilities of two tri-Fe^III clusters and one di-Fe^III cluster derived from for spin pairs coupled through the isotropic exchange interactions.     

Click maltose as an alternative to reverse phase material for desalting glycopeptides

Desalting peptides before mass spectrometry analysis is important because salts lead to adduct formation, increased chemical noise and ion suppression effect. A high concentration of salt can clog nanoelectrospray ionization (ESI) emitters. The reverse phase C18 material is commonly used to desalt peptides because of its high binding capacity. However, peptides with high hydrophilicity, such as glycopeptides, are not retained well on this material, resulting in the loss of peptide information. To improve the efficiency of glycopeptide desalting, we introduced a hydrophilic interaction chromatography (HILIC)-based material named click maltose. Four glycoproteins, horseradish peroxidase (HRP), human serum immunoglobulin G (IgG), bovine ribonuclease B (RNase B), and α-1 acid glycoprotein (AGP) were chosen as models and their glycopeptides were desalted with click maltose, AQ C18, Empore C18 and ZipTip C18. Click maltose as a HILIC material exhibited better performance than the other three C18 materials for both number of targeted glycopeptides and their corresponding intensities. In addition, accurate glycopeptide profiling was achieved with click maltose desalting regardless of peptide lengths and glycan types.     

Determination of phenylenediamine isomers in hair dyes by coal cinders micro-column extraction and MEKC

A new micellar electrokinetic chromatography (MEKC) method using beta-cyclodextrins (β-CDs) and 1-butyl-3-methylimidazolium hexafluorophosphates (ionic liquids) as additives was successfully developed for determination of para-, meta-, and ortho-phenylenediamines isomers (p-P, m-P, and o-P) in hair dyes. To improve the sensitivity of the MEKC-UV, a simple and cheap flow injection (FI) technique using a micro-column packed with coal cinders (the by-products from combustion in a boiler) as solid-phase extractant was also investigated. In the presence of 20 mmol L(-1) phosphates at pH 5.5, addition of 12 mmol L(-1) ionic liquids and 8 mmol L(-1) β-CDs greatly improved the separation efficiency. The three analytes could be quantitatively adsorbed by coal cinders, and desorbed readily with 0.15 mL of 0.01 mol L(-1) NaOH. Under the optimum conditions, an enrichment factor (EF) of 33.3 was obtained, and determination limits of p-P, m-P, and o-P were 1.97?×?10(-7), 0.99?×?10(-7), and 0.61?×?10(-7) mol L(-1), respectively. The adsorption capacities of the coal cinders micro-column for p-P, m-P, and o-P were all 1.20 mg g(-1). The presented procedure was successfully applied to the determination of p-P, m-P, and o-P in hair dyes with satisfactory results.