Nanohybrid Comprising Gold Nanoparticles – MoS2 Nanosheets for Electrochemical Sensing of Folic Acid in Serum Samples

Folic acid (FA) deficiency is associated with several clinical conditions such as megaloblastic anemia, neuropsychiatric, and pregnancy-related syndromes, this makes FA an important metabolite to be monitored. We have fabricated an electrochemical biosensor based on gold nanoparticles decorated molybdenum disulfide nanosheets (AuNPs−MoS₂NSs) nanocomposite as a transducer matrix for specific and rapid electrochemical detection of FA. Differential pulse voltammetry (DPV) studies displayed a rapid analytical response of the fabricated AuNPs−MoS₂NSs/GCE sensor probe towards FA in a wide concentration range of 0.001–100 μM with a very low detection limit of 0.72±0.03 nM. The selectivity of the fabricated sensor probe has been examined in the presence of interferents such as dopamine, uric acid, ascorbic acid, glucose, and urea. The clinical potential of the fabricated biosensor was established by monitoring FA in human serum samples. The developed AuNPs−MoS₂NSs/GCE sensor probe showed high reproducibility and stability, indicating its promise for FA detection in clinical settings.     

3D-printed Electrochemical Sensor for Organophosphate Nerve Agents

3D-printing has revolutionized various industries and scientific research by its substantial benefits such as fast prototyping, high accuracy, durability, and customized shapes. Fused deposition modeling has been used in the fabrication of 3D-printed nanocarbon electrodes. Utilization of these 3D-printed nanocarbon electrodes in the identification of organophosphates (OPs) such as parathion, methyl parathion, paraoxon, and fenitrothion, has not been reported. These compounds are highly toxic and used as chemical warfare agents and pesticides. Herein, we show that 3D-printing can be utilized for low-cost and diagnosis of priority nerve agents.     

Room-Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System

The dimethylamino functionality has significant importance in industrially relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room-temperature dimethylamination of chloroheteroarenes performed via the in-situ generation of dimethylamine using N,N-dimethylformamide (DMF) as precursor wiith a large substrate scope that includes various heteroarenes, purines as well as commercially relevant drugs such as altretamine, ampyzine and puromycin precursor.