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排序方式: 共有196条查询结果,搜索用时 15 毫秒
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Fiorella Di Nicuolo Roberta Castellani Alessandra De Cicco Nardone Greta Barbaro Carmela Paciullo Alfredo Pontecorvi Giovanni Scambia Nicoletta Di Simone 《Molecules (Basel, Switzerland)》2021,26(2)
Endometriosis is an estrogen-linked gynecological disease defined by the presence of endometrial tissue on extrauterine sites where it forms invasive lesions. Alterations in estrogen-mediated cellular signaling seems to have an essential role in the pathogenesis of endometriosis. Higher estrogen receptor (ER)-β levels and enhanced ER-β activity were detected in endometriotic tissues. It is well known that ER-β interacts with components of the cytoplasmic inflammasome-3 (NALP-3), the NALP-3 activation increases interleukin (IL)-1β and IL-18, enhancing cellular adhesion and proliferation. Otherwise, the inhibition of ER-β activity suppresses the ectopic lesions growth. The present study aims to investigate the potential effect of α-lipoic acid (ALA) on NALP-3 and ER-β expression using a western blot analysis, NALP-3-induced cytokines production by ELISA, migration and invasion of immortalized epithelial (12Z) and stromal endometriotic cells (22B) using a 3D culture invasion assay, and matrix-metalloprotease (MMPs) activity using gelatin zymography. ALA significantly reduces ER-β, NALP-3 protein expression/activity and the secretion of IL-1β and IL-18 in both 12Z and 22B cells. ALA treatment reduces cellular adhesion and invasion via a lower expression of adhesion molecules and MMPs activities. These results provide convincing evidence that ALA might inhibit endometriosis progression. 相似文献
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We evaluate quasielastic double-differential antineutrino cross sections obtained in a phenomenological model based on the superscaling behavior of electron scattering data and estimate the contribution of the vector meson-exchange currents in the two-particle-two-hole sector. We show that the impact of meson-exchange currents for charge-changing antineutrino reactions is much larger than in the neutrino case. 相似文献
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Abe F Albrow MG Amendolia SR Amidei D Antos J Anway-Wiese C Apollinari G Areti H Atac M Auchincloss P Azfar F Azzi P Bacchetta N Badgett W Bailey MW Bao J de Barbaro P Barbaro-Galtieri A Barnes VE Barnett BA Bartalini P Bauer G Baumann T Bedeschi F Behrends S Belforte S Bellettini G Bellinger J Benjamin D Benlloch J Bensinger J Benton D Beretvas A Berge JP Bertolucci S Bhatti A Biery K Binkley M Bird F Bisello D Blair RE Blocker C Bodek A Bokhari W Bolognesi V Bortoletto D Boswell C Boulos T 《Physical review letters》1995,75(4):608-612
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Abe F Albrow M Amidei D Anway-Wiese C Apollinari G Areti H Auchincloss P Azfar F Azzi P Bacchetta N Badgett W Bailey MW Bao J de Barbaro P Barbaro-Galtieri A Barnes VE Barnett BA Bartalini P Bauer G Baumann T Bedeschi F Behrends S Belforte S Bellettini G Bellinger J Benjamin D Benlloch J Benton D Beretvas A Berge JP Bertolucci S Bhatti A Biery K Binkley M Bird F Bisello D Blair RE Blocker C Bodek A Bolognesi V Bortoletto D Boswell C Boulos T Brandenburg G Buckley-Geer E Budd HS Burkett K 《Physical review letters》1994,72(19):3004-3008
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Abe F Albrow M Amidei D Anway-Wiese C Apollinari G Areti H Auchincloss P Azfar F Azzi P Bacchetta N Badgett W Bailey MW Bao J de Barbaro P Barbaro-Galtieri A Barnes VE Barnett BA Bartalini P Bauer G Baumann T Bedeschi F Behrends S Belforte S Bellettini G Bellinger J Benjamin D Benlloch J Benton D Beretvas A Berge JP Bertolucci S Bhatti A Biery K Binkley M Bird F Bisello D Blair RE Blocker C Bodek A Bolognesi V Bortoletto D Boswell C Boulos T Brandenburg G Buckley-Geer E Budd HS Burkett K 《Physical review letters》1994,73(2):220-224
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Abe F Albrow MG Amidei D Antos J Anway-Wiese C Apollinari G Areti H Atac M Auchincloss P Azfar F Azzi P Bacchetta N Badgett W Bailey MW Bao J de Barbaro P Barbaro-Galtieri A Barnes VE Barnett BA Bartalini P Bauer G Baumann T Bedeschi F Behrends S Belforte S Bellettini G Bellinger J Benjamin D Benlloch J Bensinger J Benton D Beretvas A Berge JP Bertolucci S Bhatti A Biery K Binkley M Bird F Bisello D Blair RE Blocker C Bodek A Bokhari W Bolognesi V Bortoletto D Boswell C Boulos T Brandenburg G 《Physical review letters》1994,73(17):2296-2300