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61.
Charlne Gadais Justyna Piekielna-Ciesielska Jolien De Neve Charlotte Martin Anna Janecka Steven Ballet 《Molecules (Basel, Switzerland)》2021,26(17)
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use. To answer these liabilities, designed multiple ligands (DMLs) offer a promising strategy by co-targeting opioid and non-opioid signaling pathways involved in nociception. Despite being intimately linked to the Substance P (SP)/neurokinin 1 (NK1) system, which is broadly examined for pain treatment, the neurokinin receptors NK2 and NK3 have so far been neglected in such DMLs. Herein, a series of newly designed opioid agonist-NK2 or -NK3 antagonists is reported. A selection of reported peptidic, pseudo-peptidic, and non-peptide neurokinin NK2 and NK3 ligands were covalently linked to the peptidic μ-opioid selective pharmacophore Dmt-DALDA (H-Dmt-d-Arg-Phe-Lys-NH2) and the dual μ/δ opioid agonist H-Dmt-d-Arg-Aba-βAla-NH2 (KGOP01). Opioid binding assays unequivocally demonstrated that only hybrids SBL-OPNK-5, SBL-OPNK-7 and SBL-OPNK-9, bearing the KGOP01 scaffold, conserved nanomolar range μ-opioid receptor (MOR) affinity, and slightly reduced affinity for the δ-opioid receptor (DOR). Moreover, NK binding experiments proved that compounds SBL-OPNK-5, SBL-OPNK-7, and SBL-OPNK-9 exhibited (sub)nanomolar binding affinity for NK2 and NK3, opening promising opportunities for the design of next-generation opioid hybrids. 相似文献
62.
In this paper, we study the existence, continuation and bifurcation from infinity of2π-periodic solutions of autonomous Newtonian systems. We underline that the resonant case is considered. To prove the results, we apply the degree for S1-equivariant gradient maps defined by Rybicki (1994) in [15] and the angle condition introduced by Bartsch and Li (1997) in [16]. 相似文献
63.
Bis- and tris(methylated) derivatives of 3,3'-bis(N-confused porphyrin) were obtained. Methylation of C21 stabilizes the geometry of the axially chiral system allowing separation of enantiomers and assignment of an absolute configuration by X-ray methods. 相似文献
64.
Julia Woch Edyta Maachowska Kamil Korasiak Aneta Lipkiewicz Marcin Dubowik Justyna Chrobak Jolanta Iowska Piotr Przybysz 《Molecules (Basel, Switzerland)》2022,27(3)
Petroleum, synthetic, and natural waxes have been used as hydrophobic bases for dispersions intended for use as barrier coatings for packaging paper. Oil-in-water dispersions with alkaline pH were prepared by a two-step homogenization procedure containing paraffin wax, with various characteristics, the Fischer–Tropsch synthesis product or beeswax. The size of the dispersed particles determined by dynamic light scattering depended on the type of hydrophobic base used and was in the range of 350–440 nm. The ability of dispersion particles in aggregation driven by electrostatic attraction, evaluated by Zeta potential analysis by electrophoretic light scattering, was from −26 to −50 mV. Static multiply light scattering was used for 30 days of stability assessment and helped to select the dispersion with a Sarawax SX70 wax base as the most stable. Dispersions were further used for coating the backing of kraft paper by the Meyer rod method. Coated paper with an applied coating of 6 g/m2 had very good hydrophobic properties (Cobb60 < 4 g/m2), sufficient strength properties, and air permeation, which enabled its application as a packaging material. The dispersions based on Sarawax SX70 wax were evaluated as the best coating for Mondi ProVantage Kraftliner 125 g/m2 backing paper. Good hydrophobic properties and strength properties indicate the possibility of using the SX70-based wax dispersion coating as a replacement for PFAS coatings in some applications. 相似文献
65.
Conventional biomechanical analyses of human movement have been generally derived from linear mathematics. While these methods can be useful in many situations, they fail to describe the behavior of the human body systems that are predominately nonlinear. For this reason, nonlinear analyses have become more prevalent in recent literature. These analytical techniques are typically investigated using concepts related to variability, stability, complexity, and adaptability. This review aims to investigate the application of nonlinear metrics to assess postural stability. A systematic review was conducted of papers published from 2009 to 2019. Databases searched were PubMed, Google Scholar, Science-Direct and EBSCO. The main inclusion consisted of: Sample entropy, fractal dimension, Lyapunov exponent used as nonlinear measures, and assessment of the variability of the center of pressure during standing using force plate. Following screening, 43 articles out of the initial 1100 were reviewed including 33 articles on sample entropy, 10 articles on fractal dimension, and 4 papers on the Lyapunov exponent. This systematic study shows the reductions in postural regularity related to aging and the disease or injures in the adaptive capabilities of the movement system and how the predictability changes with different task constraints. 相似文献
66.
Jzef Gorzelany Dorota Michaowska Stanisaw Pluta Ireneusz Kapusta Justyna Belcar 《Molecules (Basel, Switzerland)》2022,27(6)
Fruit of Saskatoon (Amelanchier alnifolia Nutt.) are a good source of bioactive compounds, such as polyphenols, including anthocyanins, as well as vitamins, macro- and microelements and fibre. By treating Saskatoon fruits with gaseous ozone, and adding the material as an enhancer to barley beers, it is possible to impact the contents of bioactive compounds in the produced fruit beers. Sensory tests showed that beers made from barley with addition of Saskatoon fruit of the ‘Smoky’ cultivar were characterised by the most balanced taste and aroma. Physicochemical analyses of fruit beers, produced with Saskatoon fruit pulp added on the seventh day of fermentation, showed that the beers enhanced with ozone-treated and untreated ‘Smoky’ Saskatoon fruits had the highest contents of alcohol, 5.51% v/v and 5.66% v/v, respectively, as well as total polyphenol contents of 395 mg GAE/L and 401 mg GAE/L, respectively, and higher antioxidant activity (assessed using DPPH•, FRAP and ABTS+• assays). It was demonstrated that the ozonation process led to a decrease in the contents of neochlorogenic acid, on average by 91.00%, and of caffeic acid by 20.62%, relative to the beers enhanced with ‘Smoky’ Saskatoon fruits not subjected to ozone treatment. The present study shows that Saskatoon fruits can be used in the production of beer, and the Canadian cultivar ‘Smoky’ is recommended for this purpose. 相似文献
67.
The paper presents a stochastic method of optimization of a curriculum based on a new model of the education process, where sequential teaching may cause non-sequential learning. 相似文献
68.
Krzysztof Szczubiaka ukasz Moczek Sebastian Baszkiewicz Maria Nowakowska 《Journal of polymer science. Part A, Polymer chemistry》2004,42(15):3879-3886
A series of copolymers of acrylic acid, N‐isopropylacrylamide (NIPAM), and cinnamoyloxyethyl acrylate were synthesized and studied. The polymers were responsive to four stimuli: UV light, temperature, pH, and ionic strength. The polymeric cinnamoyl chromophores underwent efficient photodimerization with concomitant photocrosslinking of the polymeric micelles. Because of the content of NIPAM, the terpolymers displayed a lower critical solution temperature, which could be controlled by the polymer composition, pH, and ionic strength. The ability to respond to the pH resulted from the content of acrylic carboxyl groups, which became protonated at low pHs. The changes in the polymer properties due to the application of the aforementioned stimuli were studied with pyrene and perylene as fluorescent probes. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3879–3886, 2004 相似文献
69.
Justyna Sikorska 《Journal of Mathematical Analysis and Applications》2008,345(2):650-660
We study a generalized stability problem for Cauchy and Jensen functional equations satisfied for all pairs of vectors x,y from a linear space such that γ(x)=γ(y) or γ(x+y)=γ(x−y) with a given function γ. 相似文献
70.
Maria Nowakowska 《Polymer Degradation and Stability》1985,12(1):23-28
The rate constant of the reaction of styrene-butadiene copolymer (SBR) with singlet oxygen and its reactivity index were estimated from an investigation of the influence of SBR on the quantum efficiency of the photo-peroxidation of 1,3-diphenylisobenzofuran (DPBF). 相似文献