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71.
Temperature-gradient gel electrophoresis (TGGE) has been used to study the thermal unfolding of ferricytochrome c in low and high concentrations of acetic acid. It has been observed that the mobility of cytochrome c is a linear function of temperature when the system is characterized by a homogeneous population of conformation-state, single molecular species. Within the transition temperature range, the mobility clearly displays the characteristic sigmoidal shape describing the transitions of protein unfolding. The data obtained by TGGE were used to estimate the apparent thermodynamic parameters (enthalpy change deltaHvh and transition temperature Tm), associated with the transition of unfolding. The accuracy of the apparent thermodynamic parameters obtained by this method agrees within error limits with the values obtained by direct calorimetric measurements using differential scanning calorimetry (DSC). 相似文献
72.
1,5-Bis(dicarboxymethylaminomethyl)-2,6-dihydroxynaphthalene (BDDN) forms fluorescent complexes with aluminium, barium, beryllium, calcium, magnesium and strontium. All the complexes have 2:1 metal :ligand ratios. Barium, calcium, magnesium and strontium exhibit maximal fluorescence at pH 11.7, with excitation and emission maxima at 385 and 445 nm respectively. Aluminium and beryllium show maximal fluorescence at pH 5.8 and 5.2 respectively, the excitation and emission maxima being at 370 and 405 nm. The formation of the calcium complex provides a highly sensitive and selective determination of calcium in the range 10/2-500 ng. The fluorescence measurement of calcium should be made within 5 min of mixing the solutions because of the instability of the reagent at the given pH. Potassium cyanide may be used as a masking agent and ter- or quadrivalent cations should be removed by preliminary extraction with 8-hydroxyquinoline in chloroform at pH 6.0. In such conditions, of 33 cations studied, only magnesium (>20 ng), strontium (>70 ng) and barium (>150 ng) caused interference in the determination of 300 ng of calcium. Among 16 anions examined, only EDTA interfered seriously. 相似文献
73.
74.
Modified silicagel (C18) was studied for separation and preconcentration of platinum group metals (Ru, Rh, Pd, Os, Ir and Pt) as ion associates of their chlorocomplexes with cation of onium salt N(1-carbaethoxypentadecyl)-trimethyl ammonium bromide. Sample containing HCl and the onium salt was pumped through the column. After elution with ethanol the eluate was evaporated in the presence of HCl. Resulting aqueous solutions were analysed with inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma mass spectrometry (ICP-MS). Recovery values of 1-20 mug Pt and Pd from 50 ml of synthetic pure solution were 100+/-3 and 100+/-1%, respectively, however, they diminished with increasing sample volume and in the presence of the real sample matrix or nitrate ions. Samples of engine soot (NIES No. 8), decomposed by low pressure oxygen high-frequency plasma, and airborne particulates from dust filters of meteorological stations, leached with HNO(3) and H(2)O(2), were analysed. A reasonable agreement was found between ICP-MS and ICP-AES results for airborne dust samples and the values comparable with those in literature were determined in NIES No. 8. 相似文献
75.
Thorsteinn Loftsson Hákon H. Sigurdsson Dagný Hreinsdóttir Fífa Konrádsdóttir Einar Stefánsson 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):585-589
Due to anatomic barriers and lacrimal drainage it is difficult to obtain therapeutic drug concentrations in the posterior part of the eye after topical drug administrations. Lipophilic cyclodextrins, such as randomly methylated β-cyclodextrin (RMβCD), are known to act both as solubilizers of water-insoluble drugs in aqueous solutions and as penetration enhancers that reduce the barrier function of lipophilic membranes. The purpose of this study was to investigate the effects of RMβCD on dexamethasone delivery from aqueous eye drop solution into rabbit eyes. Dexamethasone (0.5 and 1.5% w/v) drops (50 μl) were administered to the left eye of rabbits (n = 6) and the drug levels measured in different eye tissues 2 h after administration. In aqueous humor dexamethasone levels were 1,190 ± 110 and 1,670 ± 630 ng/g (mean ± SD) after administration of the 0.5 and 1.5% dexamethasone eye drops, respectively. In the retina the levels were 33 ± 7 and 66 ± 49 ng/g, and in optic nerve 41 ± 12 and 130 ± 50 ng/g, respectively. In a previous study the dexamethasone concentration in aqueous humor after topical administration of 1.3% (w/v) dexamethasone eye drops in aqueous 2-hydroxypropyl-β-cyclodextrin (HPβCD) solution was determined to be 320 ± 230 ng/g and 66 ± 20 ng/g after administration of Maxidex® eye drops. Both the hydrophilic HPβCD and the lipophilic RMβCD enhance topical dexamethasone delivery into the eye, but of the two, the lipophilic RMβCD results in higher dexamethasone concentrations. 相似文献
76.
Dithizonates and diethyldithiocarbamates of Ag, Tl(I), Cu(II), Zn, Cd, Hg(II), Pb, Fe(II), Co(II), Ni, Pd(II), In(III), As(III), Sb(III), Bi, Se(IV) and Te(IV) have been prepared and their reactions in carbon tetrachloride have been studied spectrophotometrically. From the exchange constants determined, the extraction constants of metal diethyldithiocarbamates have been calculated. Where formation of mixed chelates has been observed, corresponding exchange constants have been determined. Finally, the influence of organic solvents (CCl(4), CHCl(3), C(6)H(6) and C(6)H(5)Cl) on the exchange reaction of zinc diethyldithiocarbamate with dithizone has been investigated. 相似文献
77.
A phenomenological model is proposed to account for the variation of carbon diffusivityD(N1) with composition in austenite. This model is based on Parris-McLellan's statement that the increase ofD(N1) with carbon concentrationN
1 is due to the increase in chemical driving force. The gradient of the carbon activity in Wagner's and in Zupp-Stevenson's interpretation is presumed to be the intrinsic driving force. The predictions of the model are compared with carbonD(N1) values both with [1] and without [5] a chemical concentration gradient. TheD(0) values and the carbon-carbon interaction coefficients
1 are calculated by the use of the least squares method from the experimental data. The application of Zupp-Stevenson's definition of the activity coefficient
1 results in a better fit of the theory to the experimental data. 相似文献
78.
The interdiffusion in the Co-Ni system has been investigated in the temperature range of 950 to 1150 °C, by means of diffusion specimens of pure Co and Ni. The concentration curvesN(x, t) obtained with the aid of an JXA-3 A JEOL electron microprobe were evaluated using the smoothing cubic spline method by means of the Boltzmann-Matano equation. The obtained interdififusion coefficient values ¯D increase with the increasing Ni concentration and satisfy the Arrhenius equation at temperaturesH 990 °C. At lower temperatures the influence of high diffusivity paths may be effective, resulting in higher ¯D values. No expressive influence of atomic (Ni3Co) or magnetic order on the interdiffusion has been detected. The activation enthalpyH values were found almost concentration independent. A Kirkendall effect study has been carried out with positive results which are presented in Part II of this paper. A new method for the determination of diffusants concentration in the Kirkendall plane was proposed. With the use of this method and of Darken equations the intrinsic diffusion coefficients were calculated. These results are given in Part III. 相似文献
79.
Jozef Chomič Ján Skoršepa Juraj Černák Alexander Hudák 《Monatshefte für Chemie / Chemical Monthly》1982,113(6-7):713-714
The preparation, identification and some properties of three new clathrate compounds Cd(mea)[Pd(CN)4] · 2C6H6, Cd(mea)2[Pd(CN)4] · C4H4S and Cd(mea)2[Pd(CN)4] · C4H4NH (mea = HO-CH2-CH2-NH2) are described. 相似文献
80.
Instrumental neutron activation was used for the determination of 23 trace and minor elements in 4 different samples of brewer's
yeast. Detection limits for these elements vary from 2 ppb to 100 ppm. The following average concentrations were found (ppm,
dry weight): Al 597, Br 0.36, Cl 1473, Co 0.21, Cu 19, Fe 285, K 16 400, Mg 1355, Mn 8.4, Na 2330, Rb 19, Sb 0.053, Se 1.2,
V 2.2 and Zn 80. NBS standard 1569 was also analyzed and the following concentrations (in ppm) were measured: Al 2300, Br
0.65, Ce 0.23, Cl 460, Co 0.26, Cr 2.12, Cu 11, Fe 707, Gd 7.1, Hf 0.13, K 15 500, Mg 1780, Mn 7, Na 510, Rb 16, Sb 0.075,
Sc 0.18, Se 0.92, Th 3.7, Ti 38, U 0.49, V 4.1 and Zn 70. 相似文献