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11.
Renal Clearable Luminescent WSe2 for Radioprotection of Nontargeted Tissues during Radiotherapy 下载免费PDF全文
Haixia Liu Junying Wang Yaqi Jing Jiang Yang Xueting Bai Xiaoyu Mu Fujuan Xu Xuhui Xue Lingfang Liu Yuan‐Ming Sun Qiang Liu Haitao Dai Changlong Liu Xiao‐Dong Zhang 《Particle & Particle Systems Characterization》2017,34(6)
High‐energy ionizing radiation is widely used in medical diagnosis and cancer radiation therapy. However, high‐energy radiation can also impose significant damages in healthy tissues during medical treatments via direct DNA damages and indirect damages from production of reactive oxygen species (ROS). Therefore, it is urgent to develop highly effective radioprotectants with low toxicities that can meet the increasing needs for alleviating the adverse effects from cancer radiation therapy and nuclear emergency. In this work, strongly catalytic ultrasmall (sub‐5 nm) cysteine‐protected WSe2 dots are employed to protect healthy tissues against radiation via diminishing radiation‐induced free radicals. The WSe2 dots with high surface activities can recover radiation‐induced DNA damages and eliminate the excessive ROS generated from radiation. In vivo experiments confirm that the survival rate of mice treated with WSe2 dots is significantly elevated with radiation damages postponed under exposure to high‐dose ionizing radiation. Furthermore, the free radicals in major organs and hematological system can be appreciably omitted, suggesting their unique role as free radical scavengers. These WSe2 dots in ultrasmall size show rapid renal clearance of ≈74% injection dose via urine excretion in 24 h and do not cause any apparent toxicity in vivo for up to 30 d. 相似文献
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Junying Cao & Zhenning Cai 《高等学校计算数学学报(英文版)》2021,14(1):71-112
We introduce a high-order numerical scheme for fractional ordinary differential equations with the Caputo derivative. The method is developed by dividing
the domain into a number of subintervals, and applying the quadratic interpolation
on each subinterval. The method is shown to be unconditionally stable, and for general nonlinear equations, the uniform sharp numerical order 3 − $ν$ can be rigorously
proven for sufficiently smooth solutions at all time steps. The proof provides a general guide for proving the sharp order for higher-order schemes in the nonlinear
case. Some numerical examples are given to validate our theoretical results. 相似文献
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Ding Yunqiao Li Junying Wang Shijie Junzhang Mu Qiuhong Wang Jingui 《Structural chemistry》2018,29(5):1499-1510
Structural Chemistry - The reaction mechanisms of several amino acids (Asn, Gln, Arg, His, and Lys) in the collagen with aldehyde were studied using density functional theory method. Based on the... 相似文献
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合浦珠母贝(Pinctada martensii,Dunker)珍珠囊体外预培育的初步研究 总被引:1,自引:0,他引:1
0.3%胰蛋白酶液(25℃)消化外套膜组织的第5~15min时间段所收获的细胞产物中,表皮细胞具有最高的纯度和贴壁活性;细胞悬液的体外短期培养过程中小牛血清和珠母贝组织提取物对于细胞在体外的生长和在珠核表面的贴附具有促进作用. 相似文献
16.
Changtao Ji Qi Chen Qinglian Li Hongbo Huang Yongxiang Song Junying Ma Jianhua Ju 《Tetrahedron letters》2014
McbA was characterized in vitro as a novel amide synthetase in the marinacarbolines A–D biosynthetic pathway, catalyzing amide bond formation between 1-acetyl-3-carboxy-β-carboline (1a) and substituted-β-phenethylamines (1b, 2b, 3b) and tryptamine (4b) in an ATP-dependent manner. Enzyme kinetic analyses highlight β-phenethylamine as the most suitable amine donor. McbA showed broad substrate compatibility with substituted amines; 10 new β-carboline analogues were chemoenzymatically generated. 相似文献
17.
Jinlong Jiang Hao Huang Qiong Wang Weijun Zhu Junying Hao Weimin Liu 《Surface and interface analysis : SIA》2014,46(3):139-144
The titanium/silicon mono‐ and co‐doped amorphous carbon films were deposited by mid‐frequency magnetron sputtering Ti target, Si target, and Ti80S20 alloy target, respectively. The effects of doped elements on the composition, surface morphology, microstructure, and mechanical and tribological properties of the films were investigated. The results reveal that the ratio of sp3 and sp2 carbon bonds of the films is regulated between 0.28 and 0.62 by a combination of Ti and Si dopant. The addition of small amounts of silicon leads to an increase in sp3 bonds and disorder degree of the sp2 carbon. The co‐doped film exhibits significantly superior friction performance than the mono‐doped films. The ultra‐low friction (μ < 0.01) was achieved under a load of 2 N in ambient air with 40% RH. By comparing to the mono‐and co‐doped films, it is thought that the sp3/sp2 ratio of the films may play a key role for the superlow friction. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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An asymmetric Michael-type reaction of phosphorus ylides and α,β-unsaturated ketones under the catalysis of a chiral ion pair catalyst has been described. The ion pair catalyst containing a chiral counteranion was prepared by simply mixing 9-amino-(9-deoxy)-epi-quinine with l-N-Boc-proline. The optically active α-methylene-δ-ketoesters could be obtained with good to excellent enantioselectivities (up to 95% ee) under mild reaction conditions. 相似文献
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