Prominin‐1‐Specific Binding Peptide‐Modified Apoferritin Nanoparticle Carrying Irinotecan as a Novel Radiosensitizer for Colorectal Cancer Stem‐Like Cells

Resistance of cancer stem cells to radiotherapy remains a major obstacle to successful cancer management. Prominin‐1 (PROM1) is a cancer stem cell marker. Nanoparticle (NP) chemotherapeutics preferentially accumulate in tumors and are able to target cancer and cancer stem‐like cells through cancer cell‐specific ligands, making them uniquely suited as radiosensitizers for chemoradiation therapy. Using a biocompatible apoferritin NP, a PROM1‐targeted NP carrying irinotecan (PROM1‐NP) is engineered. The synergistic effect of the NP and irradiation is evaluated in PROM1‐overexpressing HCT‐116 colorectal cancer cell lines in vitro and in vivo. PROM1‐NP has a size of 17.2 ± 0.2 nm and surface charge of ?13.5 ± 0.2 mV. It demonstrates higher intracellular uptake than nontargeted NP or irinotecan alone. Treatment with PROM1‐NPs decreases HCT‐116 cell proliferation in a dose‐ and time‐dependent manner. In vitro radiosensitization reveals that PROM1‐NP is significantly more effective as a radiosensitizer than nontargeted NP or irinotecan. HCT‐116 tumor xenograft growth is markedly slower following treatment with PROM1‐NP plus irradiation, suggesting that PROM1‐NP is more effective as a radiosensitizer than irinotecan and nontargeted NP in vivo. This study provides the first preclinical evidence of the effectiveness of PROM1‐targeted NP formulation of irinotecan as a radiosensitizer.     

RF and field measurements of the SSC-LINAC RFQ

The 53.667 MHz continuous-wave heavy ion RFQ has been designed and manufactured for the SSC-LINAC project.This four-rod RFQ accelerates ions with maximum mass to charge ratio of 7 from 3.728 keV/u to 143 keV/u.Measurements have been carried out to check the RF performance of the cavity and the quality of the electric field.The S11 of the power coupler is adjusted to better than-44 dB,and the Q0 of the cavity is 6440.The quality of the electric field is evaluated by the perturbation method.The measurement procedure and data analysis will be discussed in detail.The error due to gravity of the perturbation bead has been corrected by averaging the fields in different quadrants.As a result,the unflatness of the electric field is±2.5%,and the dipole field component distributes from 0%to 20%in different longitudinal positions,which indicates the asymmetry of the quadrupole field.The unflatness of the quadrupole field distribution represents a good agreement with the simulation results.High power RF test and beam commissioning of the RFQ are on schedule in early 2014.     

Nonclassicality and Decoherence of the Variable Arcsine State in a Thermal Environment

A kind of non-Gaussian state—variable arcsine state is studied by using the input-output theories which relate the statistical properties of the output field to those of the input field. The variable arcsine state (VAS) is generated by using a variable beam splitter (BS), which means that the transmissivity (reflectivity) of the BS is adjustable continuously. The nonclassicality is investigated by studying the negativity of Wigner function (WF). It is shown that the variable arcsine state has negative values of WF when transmissivity is not equal to 1 or 0. The decoherence effect of the VAS is then studied by analytically deriving the time evolution formula of WF.     

Structure of Lennard–Jones nanowires encapsulated by carbon nanotubes

Molecular dynamics simulations have been performed to investigate the structures of Lennard–Jones(LJ) nanowires(NWs) encapsulated in carbon nanotubes(CNTs). We find that the structures of NWs in a small CNT only adopt multi-shell motifs, while the structures of NWs in a larger CNT tend to adopt various motifs. Among these structures, three of them have not been reported previously. The phase boundaries among these structures are obtained regarding filling fractions, as well as the interaction between NWs and CNTs.     

板条Nd:YAG晶体的合成盘抛光技术

针对高功率板条激光器核心工作器件——板条Nd:YAG晶体的超精密加工开展研究,分析了具有特殊构型的板条Nd:YAG晶体元件的加工性能及工艺难点,提出了一种新的基于合成盘抛光的板条Nd:YAG晶体加工工艺,并对规格为100mm×30mm×3mm的板条Nd:YAG晶体进行了加工实验。实验结果表明,合成盘抛光可以很好地控制元件的塌边现象;通过磨料的优化选择,在合成盘抛光工艺中匹配合适粒度的Al2O3磨料能够实现元件的低缺陷加工,元件下盘后的全反射面平面度达0.217λ(1λ=632.8nm),端面平面度达到0.06λ,表面粗糙度达0.55nm(RMS),端面楔角精度可达2″。     

高辐射效率超宽谱脉冲辐射天线的设计与实验

设计了一种采用共面TEM馈电结构的抛物反射面超宽谱脉冲辐射天线,分析了该种馈电结构的阻抗特性与辐射特性。实验表明当馈入电压为3kV、前沿180ps的超宽谱脉冲时,该天线主轴辐射场测试距离与峰值场强之积平均值达到18.3kV,相较于常用的TEM喇叭馈电的超宽带反射面天线,其辐射效率有了显著的提高。     

Room-Temperature Magnetism Realized by Doping Fe into Ferroelectric LiTaO3

We synthesize LiTal-x FexO3-σ （LTFO） remain single phase up to x = 0.09 ceramics by the conventional solid-state reaction method. The samples The magnetic measurements show that the doping of Fe successfully realizes ferromagnetism of LTFO at room temperature. The dielectric measurements indicate that LTFO is ferroelectric, similarly to LiTaO3 （LTO）, but its ferroelectric Curie temperature seems to decrease with the increasing Fe content. By means of doping Fe ions into LTO, the coexistence of spontaneous electric polarization and spontaneous magnetic moment is realized at room temperature.     

A diode laser spectrometer at 634nm and absolute frequency measurements using optical frequency comb

This paper reports that two identical external-cavity-diode-laser (ECDL) based spectrometers are constructed at 634 nm referencing on the hyperfine B-X transition R(80)8-4 of ¹²⁷I₂. The lasers are stabilized on the Doppler-free absorption signals using the third-harmonic detection technique. The instability of the stabilized laser is measured to be 2.8×10^-12 (after 1000 s) by counting the beat note between the two lasers. The absolute optical frequency of the transition is, for the first time, determined to be 472851936189.5 kHz by using an optical frequency comb referenced on the microwave caesium atomic clock. The uncertainty of the measurement is less than 4.9 kHz.     

EAST装置内置低温冷凝泵低温分配阀箱的研制

在全超导磁约束核聚变试验装置EAST中,为了防止杂质从偏虑器靶板附近进入等离子体核心,为EAST长脉冲放电试验提供持续的排灰能力以及装置长冲放电等,低温冷凝泵是必不可少的部件之一,在装置真空室上下安装了内置低温凝泵以提高装置运行参数,为满足低温泵的低温条件,增加一低温分配阀箱给内置低温冷凝泵提供低温条件。文中介绍应用于EAST装置系统中的内置低温冷凝泵分配阀箱研制的技术要求、冷却流程、结构特征。