Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level

Background  

Protein kinase C interacting protein (PKCI/HINT1) is a small protein belonging to the histidine triad (HIT) family proteins. Its brain immunoreactivity is located in neurons and neuronal processes. PKCI/HINT1 gene knockout (KO) mice display hyper-locomotion in response to D-amphetamine which is considered a positive symptom of schizophrenia in animal models. Postmortem studies identified PKCI/HINT1 as a candidate molecule for schizophrenia and bipolar disorder. We investigated the hypothesis that the PKCI/HINT1 gene may play an important role in regulating mood function in the CNS. We submitted PKCI/HINT1 KO mice and their wild type (WT) littermates to behavioral tests used to study anti-depressant, anxiety like behaviors, and goal-oriented behavior. Additionally, as many mood disorders coincide with modifications of hypothalamic-pituitary-adrenal (HPA) axis function, we assessed the HPA activity through measurement of plasma corticosterone levels.     

Optimization of the wash process and wash water recycling in the preparation of MgZnAl-CO3 layered double hydroxides

An MgZnAl-CO3 layered double hydroxide (LDH) slurry with Na2 SO4 as the by-product has been prepared by a co-precipitation method.The filtrates in the LDH washing process were collected according to their different levels of salinity.Filtrates with lower salinity can be used to wash a LDH slurry with higher salinity in the next cycle.Only in the final stages is pure water used.Recycling of the wash water in this way has been employed in a commercial production process,resulting in a water-saving of over 80%.The resulting MgZnAl-CO3-LDH product has a well-formed crystalline layered structure with a low content of impurities.     

局部误差的有界约束非线性方程组的非单调信赖域算法

本文提供了在没有非奇异假设的条件下,求解有界约束半光滑方程组的投影信赖域算法.基于一个正则化子问题,求得类牛顿步,进而求得投影牛顿步.在合理的假设条件下,证明了算法不仅具有整体收敛性而且保持超线性收敛速率.     

Threshold control of mutual insurance with limited commitment

We study the optimal premium policy of mutual insurance when the charged premium cannot be higher than a preset rate. We provide a complete solution to the problem and use numerical simulations to illustrate how the optimal premium policy responds to changes of outside factors. The results are useful for mutual insurance firms to design premium policies and can be used to test the behavior of these firms in empirical studies.     

Dye-sensitized solid-state solar cells fabricated by screen-printed TiO_2 thin film with addition of polystyrene balls

The screen-printed nanoporous TiO2 thin film was employed to fabricate dye-sensitized solid-state solar cells using CuI as hole-transport materials. The solar cell based on nanoporous TiO2 thin film with large pores formed by the addition of polystyrene balls with diameter of 200 nm to the TiO2 paste exhibits photovoltaic performance enhancement, which is attributed to the good contact of CuI with surface of dye-sensitized thin film due to easy penetration of CuI in the film with large pores.     

以学生为主体的混合式个性化教学模式在分析化学课程中的探索与思考

In order to solve the issues of traditional teaching methods in the undergraduate basic theory course, the blended learning mode was put forward by taking analytical chemistry as an example. With concept of student-centered, personalized teaching, together with assistant means, was introduced to achieve the breakthrough in solving the problems. We hope to reinforce the adaptability and targeting of the course teaching.     

Liquid phase epitaxial growth and optical property of flower-like ZnO nanosheets on Zinc foil

Large scale flower-like ZnO nanosheets have been synthesized on Zinc foil by a simple hydrothermal method. Their morphology and microstructures were characterized and analyzed by X-ray spectroscopy (XRD), field emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HRTEM). The as-synthesized flower-like nanosheets are hexagonal phase single crystal with 200-300 nm in width, 50 nm in thickness. The growth process follows the liquid phase epitaxial growth mechanism. In this approach, the ZnO buffer is used as substrate for the growth of flower-like ZnO nanosheets. The growth direction of the nanosheets is the preferential [0 0 0 1] growth direction of ZnO. The photoluminescence spectrum of the sample exhibits only a sharp and strong UV emission centered at 386 nm, which indicates that the flower-like ZnO nanosheets on Zn foil are of good optical property.     

利用最小调整法求解特殊的二维0-1规划

具有特殊约束的二维0-1规划的实际应用广泛,在解法中多是应用传统算法,或是在它基础上进行改进,但是此类解法计算繁琐不易推广.针对这种情形,本文引入最小调整法处理此类问题,并将其与传统算法进行对比,充分展示了该方法的优越性,呈现出灵活、方便、简单、易行的特点.通过举例验证了方法的有效性.     

Orthorhombic B2CN crystal synthesized by high pressure and temperature

B_0.54C_0.28N_0.18 precursor powder with turbostratic structure was prepared by using melamine and boric acid. The precursor was transformed into orthorhombic B₂CN under definite high pressure and temperature conditions. The composition of the orthorhombic B₂CN powder is B_0.47C_0.23N_0.30. Its lattice parameters are a=0.4776 nm, b=0.4585 nm and c=0.3629 nm. A strong absorption band from 1088 to 1385 cm⁻¹ of orthorhombic B₂CN was observed by infrared measurement. In the photoluminescence (PL) spectrum of orthorhombic B₂CN powder measured at room temperature, a broad peak corresponding to its band-edge emission centers at 374 nm.