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81.
The direct coupling of aryl halides with thiophene would be a considerable advantage for sustainable development because of only HBr associated with a base as by-product is formed and the number of steps to prepare these compounds is less than in more classical coupling reactions. We observed that through the use of only 0.2 mol% Pd(OAc)2 as the catalyst, a range of aryl bromides undergoes coupling via a C-H bond activation/functionalization reaction with thiophene to give 2-arylated thiophenes in good yields. In most cases, only traces of polyarylated thiophenes were detected when a large excess of thiophene was employed. This air-stable catalyst can be used with a wide variety of aryl bromides. 相似文献
82.
Julien Parinet Jean Serodes François Proulx 《International journal of environmental analytical chemistry》2013,93(6):505-515
This paper describes a method of determining the following compounds in water characterised by complex matrices (raw waters and drinking waters): geosmin, 2-methylisoborneol (2-MIB), 2-isobutyl-3-methoxypyrazine (IBM), 2-isopropyl-3-methoxypyrazine (IPM) and 2,4,6-trichloroanisole (TCA). The method is carried out using headspace solid-phase microextraction (HS-SPME) combined with gas chromatography (GC) and ion trap mass spectrometry (ITMS). Several parameters of extraction and desorption were optimised through the use of a Combi PAL autosampler to automate various tasks (temperature extraction, extraction time, stir speed). Quantities of NaCl and the liquid volume/total volume ratio were also optimised. Double fragmentation (tandem MS/MS) was optimised on the target compounds. The method resulted in good linearity obtained for concentrations of 1 to 100?ng?L?1 and provided detection limits of approximately below 1?ng?L?1. Good precision (1–8%) was obtained. This method was successfully applied to the analysis of earthy and musty odours in municipal raw source waters with high concentrations of natural organic matter and in the corresponding treated waters. This is the first time MS/MS has been used to analyse odorous compounds in waters destined for human consumption. In addition, the method as developed is simple to use and lends itself to easy interpretation of chromatograms. 相似文献
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Porphyrinic compounds are widespread in nature and play key roles in biological processes such as oxygen transport in blood, enzymatic redox reactions or photosynthesis. In addition, both naturally derived as well as synthetic porphyrinic compounds are extensively explored for biomedical and technical applications such as photodynamic therapy (PDT) or photovoltaic systems, respectively. Their unique electronic structures and photophysical properties make this class of compounds so interesting for the multiple functions encountered. It is therefore not surprising that optical methods are typically the prevalent analytical tool applied in characterization and processes involving porphyrinic compounds. However, a wealth of complementary information can be obtained from NMR spectroscopic techniques. Based on the advantage of providing structural and dynamic information with atomic resolution simultaneously, NMR spectroscopy is a powerful method for studying molecular interactions between porphyrinic compounds and macromolecules. Such interactions are of special interest in medical applications of porphyrinic photosensitizers that are mostly combined with macromolecular carrier systems. The macromolecular surrounding typically stabilizes the encapsulated drug and may also modify its physical properties. Moreover, the interaction with macromolecular physiological components needs to be explored to understand and control mechanisms of action and therapeutic efficacy. This review focuses on such non-covalent interactions of porphyrinic drugs with synthetic polymers as well as with biomolecules such as phospholipids or proteins. A brief introduction into various NMR spectroscopic techniques is given including chemical shift perturbation methods, NOE enhancement spectroscopy, relaxation time measurements and diffusion-ordered spectroscopy. How these NMR tools are used to address porphyrin–macromolecule interactions with respect to their function in biomedical applications is the central point of the current review. 相似文献
89.
Mathilde Montibus Xavier Vitrac Vronique Coma Anne Loron Laetitia Pinson-Gadais Nathalie Ferrer Marie-Noëlle Verdal-Bonnin Julien Gabaston Pierre Waffo-Tguo Florence Richard-Forget Vessela Atanasova 《Molecules (Basel, Switzerland)》2021,26(2)
Fusarium graminearum is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by F. graminearum. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by F. graminearum. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling F. graminearum and its production of mycotoxins. 相似文献
90.
Tuniyazi Abuduaini Vincent Roy Julien Marlet Catherine Gaudy-Graffin Denys Brand Ccile Baronti Franck Touret Bruno Coutard Tamara R. McBrayer Raymond F. Schinazi Luigi A. Agrofoglio 《Molecules (Basel, Switzerland)》2021,26(5)
A series of hitherto unknown (1,4-disubstituted-1,2,3-triazol)-(E)-2-methyl-but-2-enyl nucleosides phosphonate prodrugs bearing 4-substituted-1,2,3-triazoles were prepared in a straight approach through an olefin acyclic cross metathesis as the key synthetic step. All novel compounds were evaluated for their antiviral activities against HBV, HIV and SARS-CoV-2. Among these molecules, only compound 15j, a hexadecyloxypropyl (HDP)/(isopropyloxycarbonyl-oxymethyl)-ester (POC) prodrug, showed activity against HBV in Huh7 cell cultures with 62% inhibition at 10 μM, without significant cytotoxicity (IC50 = 66.4 μM in HepG2 cells, IC50 = 43.1 μM in HepG2 cells) at 10 μM. 相似文献