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991.
Freire F Seco JM Quiñoá E Riguera R 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(19):5509-5522
The absolute configuration of 1,2-diols formed by a primary and a secondary (chiral) hydroxyl group can be deduced by comparison of the 1H NMR spectra of the corresponding (R)- and bis-(S)-MPA esters (MPA = methoxyphenylacetic acid). This method involves the use of the chemical shifts of substituents L1/L2 attached to the secondary (chiral) carbon, and of the hydrogen atom linked to the chiral center (C alpha-H) as diagnostic signals. Theoretical (AM1, HF, and B3 LYP calculations) and experimental data (dynamic and low-temperature NMR spectroscopy, studies on deuterated derivatives, constant coupling analysis, circular dichroism (CD) spectra, and NMR studies with a number of diols of known absolute configuration) prove that the signs of the delta delta(RS) obtained for those signals correlate with the absolute configuration of the diol. A graphical model for the reliable assignment of the absolute configuration of a 1,2-diol by comparison of the NMR spectra of its bis-(R)- and bis-(S)-MPA esters is presented. 相似文献
992.
Wetting properties of a solid surface can change as a consequence of chemical treatment. There is a relationship between the molecular structure of a surface and the macroscopic properties of this surface such as wetting and adhesion. Information on the surface energy of a solid was obtained by calculating polar and dispersion force contributions by means of contact angle determination. The superficial modification undergone by human hair treatments with or without hydrogen peroxide at alkaline pH was studied by means of wetting force measurements. The wetting increase in treated human hair fibers was analyzed following the Hüttinger method using contact angle data, taking into account the acid-base and dispersion components of the total wetting adhesion work. The hydrogen peroxide treatment at alkaline pH leads to a partial removal of hydrocarbon chains and to the formation of ionic groups (cysteic acid residues) on the outer scale cell surface. The latter phenomenon was observed by means of an increase in the acid-base adhesion work versus water wetting liquid at alkaline pH. Copyright 2001 Academic Press. 相似文献
993.
Summary Nowadays mainly triazine herbicides are used for treating cultural plants against weeds. Many methods for their determination as well as for their extraction and purification have been developed, but the latter apply mainly for the determination in plant material. In the present publication the effect of the animal organ tissue extracts on the residue determination by optical methods is investigated. The background materials obtained after extraction of sheep muscle, liver, kidney, heart and lung with acetonitrile, acetone and hexane each are investigated by means of an infrared spectrometric method. Bentazone was chosen as the model pesticide and had been toxicologically tested with two experimental groups of sheep throughout three months administered with two different dose rates. Since the main chromophore of the bentazone molecule is represented by a ketonic group which is used for the spectrophotometric determination of the substance, the elimination of the background at the respective UV region should be based on suppression of the optic activity of equivalents of similar absorbing chromophores as owned by the bentazone molecule. For this reason the cleaning capacities of the Separcol SI C18, SI C1 and Carb of Czechoslovak provenience were examined. After elimination of interfering background bentazone determination was verified at a wavelength of 219 nm. 相似文献
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997.
Valentina Domenici Dr. Carlo Alberto Veracini Prof. Vladimira Novotná Dr. Ronald Y. Dong Prof. 《Chemphyschem》2008,9(4):556-566
A liquid crystal ( HZL 7/* ) containing an (S)‐2‐methylbutyl‐(S)‐lactate unit in the chiral chain, is investigated by means of 2H and 13C NMR spectroscopy in order to obtain information on its orientational order, its molecular structure and the effect of external magnetic fields on the supramolecular structure of its phases. This mesogen presents very peculiar mesomorphic properties and exhibits frustrated TGBA* and TGBC* phases in a wide temperature range up to 60 °C, as well as an additional phase transition from TGBC1* to TGBC2*. 2H NMR measurements show, for the first time, a peculiar magnetic field effect in unwinding the supramolecular structure of both the TGBA* and TGBC* phases. This effect is particularly evident at higher magnetic fields, while different behaviour is observed at lower magnetic fields. This indicates that the supramolecular structure is very sensitive to magnetic fields of the order of 1 Tesla. Moreover, the analysis of the 2H and 13C NMR spectra of HZL 7/* allow us to obtain several structural properties, such as the tilt angle of the TGBC* phases and the local orientational order parameters referred to the phenyl and biphenyl fragments. This is the first structural characterization of the frustrated phases of these complexes by means of NMR. 相似文献
998.
Novel polymeric delivery systems for the photosensitizer mesochlorin e6 (Mce6) were synthesized to overcome problems of systemic toxicity. A disulfide bond was included to allow for quick release of Mce6 from the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone once internalized in tumor tissue. The synthesized conjugates demonstrated a time-dependent reductive cleavage with an accompanying increase in the quantum yield of singlet oxygen generation on exposure to DTT. Quicker release kinetics and a higher cytotoxicity in SKOV-3 human ovarian carcinoma cells were obtained as compared to polymer conjugate with a proteolytically cleavable GFLG spacer. These novel conjugates hold promise as clinically relevant drug delivery systems for photodynamic therapy of cancer. 相似文献
999.
Adam J Kríz Z Prokop MP Wimmerová M Koca J 《Journal of chemical information and modeling》2008,48(11):2234-2242
This article is focused on the application of two types of docking software, AutoDock and DOCK. It is aimed at studying the interactions of a calcium-dependent bacterial lectin PA-IIL (from Pseudomonas aeruginosa) and its in silico mutants with saccharide ligands. The effect of different partial charges assigned to the calcium ions was tested and evaluated in terms of the best agreement with the crystal structure. The results of DOCK were further optimized by molecular dynamics and rescored using AMBER. For both software, the agreement of the docked structures and the provided binding energies were evaluated in terms of prediction accuracy. This was carried out by comparing the computed results to the crystal structures and experimentally determined binding energies, respectively. The performance of both docking software applied on a studied problem was evaluated as well. The molecular docking methods proved efficient in identifying the correct binding modes in terms of geometry and partially also in predicting the preference changes caused by mutation. Obtaining a reasonable in silico method for the prediction of lectin-saccharide interactions may be possible in the future. 相似文献
1000.
Determination of ascorbic acid in human plasma with a view to stability using HPLC with UV detection
A method for the measurement of ascorbic acid using HPLC with UV detection and investigation into the protein precipitation techniques with regard to stability and recovery are described. The effectiveness of various protein precipitants was tested. Stability of ascorbic acid samples for analysis was investigated over 10 h. Ascorbic acid samples extracted with metaphosphoric acid were stable on a cooled autosampler (4 degrees C) for at least 10 h (with a decline of 1.8% for ascorbic acid solution and 2.8% for plasma). Perchloric acid as protein precipitant for ascorbic acid was unsuitable (with a decline of 36.0% for ascorbic acid solution and 7.3% for plasma). Analytical performance of this method is satisfactory. The intra- and interassay coefficients of variation were 2.1% (n = 10) and 5.8% (n = 12), respectively. The calibration curve was linear with the tested range of 2.0-250.0 micromol/L. The recovery was 96.1% with CV = 4.8% (n = 6) and the LOD was 3 micromol/L. The preliminary reference ranges of ascorbic acid in a group of blood donors are 50.8 +/- 22.4 micromol/L. This assay is a highly sensitive and reproducible HPLC method for the determination of ascorbic acid in human plasma. 相似文献