Equilibrium studies on complex formation reactions of dichlorido[(R,R)-trans-1,2-diaminocyclohexane]platinum(II) complex with ligands of biological significance

Abstract  

The hydrolysis and complex formation equilibria of [Pt(dach)(H₂O)₂]²⁺, where dach is (R,R)-trans-1,2-diaminocyclohexane, with some sulfur- and nitrogen-bonding ligands, such as l-methionine, glutathione, inosine, inosine-5′-monophosphate, and guanosine-5′-monophosphate, were studied in aqueous 0.10 M NaClO₄ solution at 298 K by potentiometric titrations. The experimentally determined pK _a values for the studied diaqua complex were 6.00 and 10.03, respectively. The acid dissociation constants of the ligands were also determined. The stoichiometry and stability constants of the formed complexes are reported, as well as the concentration distribution of the various complex species evaluated as a function of pH. In all studied systems, species with one coordinated molecule of ligand were detected. However, only in systems with l-methionine and inosine, complexes with two molecules of ligand directly coordinated to the Pt(II) ion were found. The results also show that glutathione formed the most stable complexes. These results could contribute to better understanding of the interactions between Pt(II) complexes and biologically significant molecules.     

Activity concentration of 40K in drinking water in Slovenia

Activity concentrations of ⁴⁰K and ³H in drinking water from four sources in the vicinity of NPP Kr?ko and their correlation with geological data are presented. The data extends from the year 1996 until present. In addition, activity concentrations of ⁴⁰K in drinking water at randomly selected sources in Slovenia are presented on a map. These activity concentrations vary by more than an order of magnitude with the largest values in northeastern part of the country.     

Control of 1,3-cyclohexadiene photoisomerization using light-induced conical intersections

We have studied the photoinduced isomerization from 1,3-cyclohexadiene to 1,3,5-hexatriene in the presence of an intense ultrafast laser pulse. We find that the laser field maximally suppresses isomerization if it is both polarized parallel to the excitation dipole and present 50 fs after the initial photoabsorption, at the time when the system is expected to be in the vicinity of a conical intersection that mediates this structural transition. A modified ab initio multiple spawning (AIMS) method shows that the laser induces a resonant coupling between the excited state and the ground state, i.e., a light-induced conical intersection. The theory accounts for the timing and direction of the effect.     

Comprehensive Evaluation of Antioxidant Activity of Ribes berry Fruit Species: A Chemometric Approach

Currant fruit extracts were characterized by (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, 2,2-azinobis-3 ethyl benzothiazoline-6-sulfonic acid cation decolorization activity, total reducing power, cupric ion reducing antioxidant power, and ferric ion reducing antioxidant power (FRAP) assays to evaluate their antioxidant activity. All five antioxidant assays revealed the highest antioxidant activity to be present for the black currants. The highest concentrations of phenolics were present in the black currants (1690?±?10?mg gallic acid equivalents (GAE)/100?g fresh weight), while the lowest value was obtained in the white currants (579?±?5?mg GAE/100?g fresh weight). The correlation between the total phenolic content and antioxidant activity assays was evaluated using regression analysis. A significant positive correlation was obtained between the total phenols and the cupric ion reducing antioxidant power (r?=?0.97, p?r?=?0.93, p?相似文献   

The stability of non-ionic surfactants and linear alkylbenzene sulfonates in a water matrix and on solid-phase extraction cartridges

The stability of nonylphenol ethoxylates (NPEO), alcohol ethoxylates (AEO), coconut diethanol amides (CDEA) and linear alkylbenzene sulfonates (LAS) in a water matrix and preconcentrated on SPE cartridges was studied. A stability study was carried out in a water matrix (spiked ground water and real-world waste water) comparing different pretreatment procedures (addition of sulfuric acid to pH = 3, preservation with 1% and 3% of formaldehyde). When stored in a water matrix serious qualitative and quantitative changes occurred in waste water during the period of time studied (30 days). The losses of C₁₂–C₁₄ alcohol ethoxylates ranged from 72% to 88% when the sample was preserved with acid and from 17% to 86% when the sample was preserved with formaldehyde (3%). Simultaneously, an enrichment of the shorter alkyl chain homologues (C₇EO and C₁₀EO) was observed. The losses of NPEO were from 45% (sample preserved by acidification or by addition of 3% of formaldehyde) to 85% (sample preserved with 1% of formaldehyde). Additionally, an increase in concentration of polyethylene glycols (PEGs) and formation of different acidic forms, such as monocarboxylated (MCPEGs) and dicarboxylated polyethylene glycols (DCPEGs) were observed. The stability of surfactants preconcentrated on SPE cartridges was studied as a function of storage time and storage conditions (room temperature, 4?°C and –20?°C). The results indicate that disposable SPE cartridges can be recommended for the stabilization of non-ionic surfactants and LAS. Storage at –20?°C is feasible for long periods (up to ¶3 months for ground water and up to 2 months for waste water), while storage at 4?°C can be recommended for a maximum of 1 month. When cartridges were kept at –20?°C the losses of AEOs (n = 12, 13 and 14), preconcentrated from waste water, ranged from 17 to 29% (after 60 days) and other compounds suffered small losses (maximum of 14% for C₁₃LAS). At room temperature, after 7 days, the losses were less than 11%, indicating that shipping of samples by mail can be done without any special requirements.     

Quasi-stable propagation of vortices and soliton clusters in saturable Kerr media with square-root nonlinearity

Analytical and numerical investigation of the propagation of optical beams in Kerr-like saturable photorefractive media is carried out, utilizing a novel model for the local isotropic part of the space-charge field generated in the medium. Using a variational technique, optimal propagation parameters for the most stable propagation of otherwise unstable single Gaussian, single vortex, and optical soliton cluster beams are determined. Analogy between a ring of identical weakly overlapping solitons and a vortex of the same topological charge is explored.     

Application of Blanc’s law at arbitrary electric field to gas density ratios

Application of Blancs law for drift velocities of electrons and ions in gas mixtures at arbitrary reduced electric field strengths E/n₀ was studied theoretically and by numerical examples. Corrections for Blancs law that include effects of inelastic collisions were derived. In addition we have derived the common mean energy procedure that was proposed by Chiflikyan in a general case both for ions and electrons. Both corrected common E/n₀ and common mean energy procedures provide excellent results even for electrons at moderate E/n₀ where application of Blancs law was regarded as impossible. In mixtures of two gases that have negative differential conductivity (NDC) even when neither of the two pure gases show NDC the Blancs law procedure was able to give excellent predictions.     

On the least eigenvalue of cacti

Among the cacti with n vertices and k cycles we determine a unique cactus whose least eigenvalue is minimal. We also explore cacti with n vertices and among them, we find a unique cactus whose least eigenvalue is minimal.     

On the Roter Type of Chen Ideal Submanifolds

Chen ideal submanifolds M ⁿ in Euclidean ambient spaces E ^n+m (of arbitrary dimensions n ?? 2 and codimensions m??? 1) at each of their points do realise an optimal equality between their squared mean curvature, which is their main extrinsic scalar valued curvature invariant, and their ???C(= ??(2)?C) curvature of Chen, which is one of their main intrinsic scalar valued curvature invariants. From a geometric point of view, the pseudo-symmetric Riemannian manifolds can be seen as the most natural symmetric spaces after the real space forms, i.e. the spaces of constant Riemannian sectional curvature. From an algebraic point of view, the Roter manifolds can be seen as the Riemannian manifolds whose Riemann?CChristoffel curvature tensor R has the most simple expression after the real space forms, the latter ones being characterisable as the Riemannian spaces (M ⁿ , g) for which the (0, 4) tensor R is proportional to the Nomizu?CKulkarni square of their (0, 2) metric tensor g. In the present article, for the class of the Chen ideal submanifolds M ⁿ of Euclidean spaces E ^n+m , we study the relationship between these geometric and algebraic generalisations of the real space forms.     

On the similarity of some three-point methods for solving nonlinear equations

In this short note we discuss certain similarities between some three-point methods for solving nonlinear equations. In particular, we show that the recent three-point method published in [R. Thukral, A new eighth-order iterative method for solving nonlinear equations, Appl. Math. Comput. 217 (2010) 222-229] is a special case of the family of three-point methods proposed previously in [R. Thukral, M.S. Petkovi?, Family of three-point methods of optimal order for solving nonlinear equations, J. Comput. Appl. Math. 233 (2010) 2278-2284].