Aspects of the transpiration model for aerofoil design

Transpiration is a technique in which extra non-physical normal flows are created on an aerofoil surface in order to form a new streamline pattern such that the surface streamlines no longer follow the aerofoil surface under inviscid flow. The transpiration model is an important technique adopted in aerofoil design either to avoid mesh regeneration when aerofoil profile co-ordinates are adjusted or to find shape corrections in inverse design methods. A first-order approximation (with respect to the normal streamline displacement) to the transpiration model is commonly adopted; it is shown that this can be a poor approximation especially in regions of high curvature. In this paper more accurate approximations are developed to address this problem and improve the accuracy.     

Performance and analysis of saddle point preconditioners for the discrete steady-state Navier-Stokes equations

Summary. We examine the convergence characteristics of iterative methods based on a new preconditioning operator for solving the linear systems arising from discretization and linearization of the steady-state Navier-Stokes equations. With a combination of analytic and empirical results, we study the effects of fundamental parameters on convergence. We demonstrate that the preconditioned problem has an eigenvalue distribution consisting of a tightly clustered set together with a small number of outliers. The structure of these distributions is independent of the discretization mesh size, but the cardinality of the set of outliers increases slowly as the viscosity becomes smaller. These characteristics are directly correlated with the convergence properties of iterative solvers. Received August 5, 2000 / Published online June 20, 2001     

Comparison of the DNA Damage Photoinduced by Fenofibrate and Ketoprofen, Two Phototoxic Drugs of Parent Structure

Fenofibrate and ketoprofen (KP) are two drugs of similar structure derived from that of benzophenone. Both are photoallergic and promote cross reactions in patients. However, the cutaneous photosensitizing properties of KP also include phototoxic effects and are more frequently mentioned. To account for this difference in their in vivo properties, their in vitro photosensitizing properties on DNA were compared. First, it was shown that under irradiation at 313 nm, fenofibric acid (FB), the main metabolite of fenofibrate, photosensitized DNA cleavage by a radical mechanism similar to that proposed for KP but with a 50 times lower efficiency. Furthermore, FB did not photosensitize the formation of pyrimidine dimers into DNA in contrast to KP, which did promote this type of DNA damage. Their difference in efficiency as DNA breakers was compared to their relative photochemical reactivity and the quantum yield of FB photolysis was found to be eightfold lower than that of KP. The reactivity of these drugs cannot explain alone the difference in their photosensitizing properties. Other factors such as the magnitude of the ionic character of the pho-todecarboxylation pathway of these benzophenone-like drugs are considered in the discussion.