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151.
Beatriz Pérez-Artacho Visitación Gallardo M. Adolfina Ruiz José L. Arias 《Journal of nanoparticle research》2012,14(4):768
A reproducible methodology is described for the synthesis, by following the double emulsion/solvent evaporation technique,
of magnetic nanocomposites (average diameter ≈ 135 nm) consisting of maghemite nuclei and a biodegradable poly(d,l-lactide-co-glycolide) matrix. The heterogeneous structure of the nanoparticles can confer them the responsiveness to magnetic gradients,
giving both the possibility of their use as a drug delivery system and adequate heating characteristics for a hyperthermia
effect. The physical chemistry of the nanocomposites was extensively characterized, this establishing that their surface properties
were similar to that of pure poly(d,l-lactide-co-glycolide). From an electrokinetic point of view, zeta potential determinations (as a function of the ionic strength, and
pH) pointed out that the nanocomposites were almost indistinguishable from the copolymer. The surface thermodynamic analysis
agreed with the electrophoretic one in suggesting that the coverage of the magnetic nuclei was complete, since the hydrophilic
nature of maghemite was modified and the nanoparticles turned into hydrophobic, just like the copolymer, when they were embedded
into poly(d,l-lactide-co-glycolide). The magnetic behaviours of the composite nanoparticles were also checked. Their heating properties were studied
in vitro in a high-frequency alternating gradient of magnetic field: a stable maximum temperature of 47 °C was satisfactorily
achieved within 45 min. Blood compatibility of the nanocomposites was also defined in vitro. To our knowledge, this is the
first time that such kind of magnetic-sensitive nanoformulation with very promising characteristics (e.g. blood compatibility,
magnetic drug targeting capabilities, and hyperthermia) has been developed for therapeutic purposes. 相似文献
152.
Eichhorn P Pérez S Aceña J Gardinali P Abad JL Barceló D 《Journal of mass spectrometry : JMS》2012,47(6):701-711
Recent publications on pharmaceutical monitoring are increasingly covering the field of illicit drugs and lately the forensic evaluation of designing illegal analogs of lifestyle drugs like the phosphodiesterase type 5 (PDE-5) inhibitors Viagra (sildenafil), Levitra (vardenafil) and Cialis (tadalafil). Recently, the presence of all three erectile dysfunction treatment drugs has been reported in wastewaters at very low concentrations. In the environment, contaminants undergo various physical or chemical processes classified into abiotic (photolysis, hydrolysis) and biotic (biodegradation) reactions. Thus, changes in the chemical structure lead to the formation of new transformation products, which may persist in the environment or be further degraded. This study describes the photolysis of sildenafil (SDF) and its human metabolite N-demethylsildenafil (DM-SDF) under simulated solar radiation (Xenon lamp). Following chromatographic separation of the irradiated samples, eight photoproducts in the SDF samples and six photoproducts for DM-SDF were detected and characterized. The combination of ultra performance liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (UPLC-ESI-QToF-MS), liquid chromatography-atmospheric pressure chemical ionization-triple quadrupole mass spectrometry (LC-APCI-QqQ-MS) and hydrogen/deuterium-exchange experiments allowed to propose plausible chemical structures for the photoproducts, taking into account the characteristic fragmentation patterns and the accurate mass measurements. These mass spectral data provided sound evidence for the susceptibility of the piperazine ring toward photodegradation. A gradual breakdown of this heterocyclic structure gave rise to a series of products, which in part were identical for SDF and DM-SDF. The sulfonic acid, as the formal product of sulfonamide hydrolysis, was identified as key intermediate in the photolysis pathway. In both drug/metabolite molecules, phototransformation processes taking place beyond the sulfonamide group were deemed to be of minor relevance. 相似文献
153.
Bouquet S Stéhlé C Koenig M Chièze JP Benuzzi-Mounaix A Batani D Leygnac S Fleury X Merdji H Michaut C Thais F Grandjouan N Hall T Henry E Malka V Lafon JP 《Physical review letters》2004,92(22):225001
We present a supercritical radiative shock experiment performed with the LULI nanosecond laser facility. Using targets filled with xenon gas at low pressure, the propagation of a strong shock with a radiative precursor is evidenced. The main measured shock quantities (electronic density and propagation velocity) are shown to be in good agreement with theory and numerical simulations. 相似文献
154.
We detail measurements of field-driven expansion and zero-field relaxation of magnetic mirror domains in antiferromagnetically coupled perpendicularly magnetized ultrathin Co layers. The zero-field stability of aligned ('mirror') domains in such systems results from non-homogeneous dipolar stray fields which exist in the vicinity of the domain walls. During field-driven domain expansion, we evidence a separation of the domain walls which form the mirror domain boundary. However, the walls realign, thereby reforming a mirror domain, if their final separation is below a critical distance at the end of the field pulse. This critical distance marks the point at which the effective net interaction between the walls changes from attractive to repulsive. 相似文献
155.
The Method of Images poses an important difficulty when used to solve the problem of a charge in the presence of a grounded conducting sphere. This arises from the fact that the sum of the inducing charge and the image charge is different from zero. As a consequence, there is a monopole field far from the system, and any ground wire physically connected to the sphere will carry an electric current, changing the initial balance of charges until a new equilibrium is reached. The approach taken in this paper assumed an infinite straight wire connecting the sphere to ground. The charge distribution over the surface of the conductors was calculated, and the results analyzed. It was shown that the thinner the wire, the lower will be its total charge, and the closer will be the calculated charge density at the surface of the sphere to the conventional solution by the Method of Images. 相似文献
156.
The folk questions in Lorentzian Geometry which concerns the smoothness of time functions and slicings by Cauchy hypersurfaces, are solved by giving simple proofs of: (a) any globally hyperbolic spacetime (M, g) admits a smooth time function whose levels are spacelike Cauchy hyperfurfaces and, thus, also a smooth global splitting if a spacetime M admits a (continuous) time function t then it admits a smooth (time) function with timelike gradient on all M.The second-named author has been partially supported by a MCyT-FEDER Grant, MTM2004-04934-C04-01.To Professor P.E. Ehrlich, wishing him a continued recovery and good health 相似文献
157.
The fracture of porous media subjected to a constant load is studied. Contrary to homogeneous solids in which fracture usually happens instantaneously at a well-defined breaking strength, the fracture of a porous medium can occur with a delay, allowing us to quantify the average lifetime of the unbroken material. We show that the average fracture probability, a key property for risk analysis in civil engineering, is given by the probability of crack nucleation. The nucleation process can be understood qualitatively by calculating the activation energy for crack nucleation, taking into account the porosity of the medium. 相似文献
158.
159.
We propose a teleportation scheme that relies only on single-photon measurements and Faraday rotation, for teleportation of many-qubit entangled states stored in the electron spins of a quantum dot system. The interaction between a photon and the two electron spins, via Faraday rotation in microcavities, establishes Greenberger-Horne-Zeilinger entanglement in the spin-photon-spin system. The appropriate single-qubit measurements, and the communication of two classical bits, produce teleportation. This scheme provides the essential link between spintronic and photonic quantum information devices by permitting quantum information to be exchanged between them. 相似文献
160.