A Markov Renewal Based Model for Wireless Networks

We propose a queueing network model which can be used for the integration of the mobility and teletraffic aspects that are characteristic of wireless networks. In the general case, the model is an open network of infinite server queues where customers arrive according to a non-homogeneous Poisson process. The movement of a customer in the network is described by a Markov renewal process. Moreover, customers have attributes, such as a teletraffic state, that are driven by continuous time Markov chains and, therefore, change as they move through the network. We investigate the transient and limit number of customers in disjoint sets of nodes and attributes. These turn out to be independent Poisson random variables. We also calculate the covariances of the number of customers in two sets of nodes and attributes at different time epochs. Moreover, we conclude that the arrival process per attribute to a node is the sum of independent Poisson cluster processes and derive its univariate probability generating function. In addition, the arrival process to an outside node of the network is a non-homogeneous Poisson process. We illustrate the applications of the queueing network model and the results derived in a particular wireless network.     

Lyapunov stability for semigroup actions

In this paper we introduce a theory of Lyapunov stability of sets for semigroup actions on Tychonoff spaces. We also present the main properties and the main results relating these new concepts. We generalize several concepts and results of Lyapunov stable sets from Bhatia and Hajek (Local Semi-Dynamical Systems. Lecture Notes in Mathematics, vol. 90. Springer, Berlin, 1969), Bhatia and Szegö (Dynamical Systems: Stability Theory and Applications. Lecture Notes in Mathematics, vol. 35. Springer, Berlin, 1967; and Stability Theory of Dynamical Systems. Springer, Berlin, 1970).     

Critical metrics of the total scalar curvature functional on 4‐manifolds

The purpose of this paper is to investigate the critical points of the total scalar curvature functional restricted to space of metrics with constant scalar curvature of unitary volume, for simplicity CPE metrics. It was conjectured in the 1980's that every CPE metric must be Einstein. We prove that a 4‐dimensional CPE metric with harmonic tensor must be isometric to a round sphere      

Equivariant Willmore surfaces in conformal homogeneous three spaces

The complete classification of homogeneous three spaces is well known for some time. Of special interest are those with rigidity four which appear as Riemannian submersions with geodesic fibres over surfaces with constant curvature. Consequently their geometries are completely encoded in two values, the constant curvature, c$c$, of the base space and the so called bundle curvature, r$r$. In this paper, we obtain the complete classification of equivariant Willmore surfaces in homogeneous three spaces with rigidity four. All these surfaces appear by lifting elastic curves of the base space. Once more, the qualitative behaviour of these surfaces is encoded in the above mentioned parameters (c,r)$(c,r)$. The case where the fibres are compact is obtained as a special case of a more general result that works, via the principle of symmetric criticality, for bundle-like conformal structures in circle bundles. However, if the fibres are not compact, a different approach is necessary. We compute the differential equation satisfied by the equivariant Willmore surfaces in conformal homogeneous spaces with rigidity of order four and then we reduce directly the symmetry to obtain the Euler Lagrange equation of 4r²$4r^2$-elasticae in surfaces with constant curvature, c$c$. We also work out the solving natural equations and the closed curve problem for elasticae in surfaces with constant curvature. It allows us to give explicit parametrizations of Willmore surfaces and Willmore tori in those conformal homogeneous 3-spaces.     

A methodology for stochastic inventory models based on a zero‐adjusted Birnbaum‐Saunders distribution

The Birnbaum–Saunders (BS) distribution is receiving considerable attention. We propose a methodology for inventory logistics that allows demand data with zeros to be modeled by means of a new discrete–continuous mixture distribution, which is constructed by using a probability mass at zero and a continuous component related to the BS distribution. We obtain some properties of the new mixture distribution and conduct a simulation study to evaluate the performance of the estimators of its parameters. The methodology for stochastic inventory models considers also financial indicators. We illustrate the proposed methodology with two real‐world demand data sets. It shows its potential, highlighting the convenience of using it by improving the contribution margins of a Chilean food industry. Copyright © 2015 John Wiley & Sons, Ltd.     

A fast meta-heuristic approach for the $$(\alpha ,\beta )-k$$-feature set problem

The feature selection problem aims to choose a subset of a given set of features that best represents the whole in a particular aspect, preserving the original semantics of the variables on the given samples and classes. In 2004, a new approach to perform feature selection was proposed. It was based on a NP-complete combinatorial optimisation problem called (\(\alpha ,\beta \))-k-feature set problem. Although effective for many practical cases, which made the approach an important feature selection tool, the only existing solution method, proposed on the original paper, was found not to work well for several instances. Our work aims to cover this gap found on the literature, quickly obtaining high quality solutions for the instances that existing approach can not solve. This work proposes a heuristic based on the greedy randomised adaptive search procedure and tabu search to address this problem; and benchmark instances to evaluate its performance. The computational results show that our method can obtain high quality solutions for both real and the proposed artificial instances and requires only a fraction of the computational resources required by the state of the art exact and heuristic approaches which use mixed integer programming models.     

Structural anomalies for a three dimensional isotropic core-softened potential

Using molecular dynamics simulations we investigate the structure of a system of particles interacting through a continuous core-softened interparticle potential. We found for the translational order parameter t a local maximum at a density rho(t-max) and a local minimum at rho(t-min)>rho(t-max). Between rho(t-max) and rho(t-min), the t parameter anomalously decreases upon increasing pressure. For the orientational order parameter Q(6) a maximum was observed at a density rho(t-max)相似文献   

A validated higher-performance liquid chromatography method for quantification of cinchonain Ib in bark and phytopharmaceuticals of Trichilia catigua used as Catuaba

The hydroalcoholic extract, prepared from authentic chopped barks of Trichilia catigua, was evaluated by high-performance liquid chromatography using a diode array detector (200-400 mn). The crude extract was purified by rotation locular counter-current chromatography and the chloroform fraction obtained was clean-up by solid-phase extraction. With the aim of getting preliminary structure information on-line, the methanol fraction thus obtained was analyzed by gradient elution using the diode array detector coupled to a mass spectrometer. The presence of flavalignan in this extract was inferred by the chromatographic band, in the total ion current trace, that had an [M-H](-) = 451. With this information, cinchonain Ib was isolated as a pure compound from the crude hydroalcoholic extract using a solid-phase extraction procedure for the sample clean-up followed by a semi-preparative separation using the reverse mode of elution. The isolated compound, after complete characterization, was used as an external standard for the development and validation of a method for the analysis of this compound in herbal medicines using the ultraviolet as the detector. The validated method has been successfully applied for quantification of cinchonain Ib in commercialized herbal medicines sold as Catuaba in Brazil and also in standard chopped barks of T. catigua.     

In vitro and in vivo inhibition of skin matrix metalloproteinases by Pothomorphe umbellata root extract

Exposure to UV radiation up-regulates the synthesis of matrix metalloproteinases (MMPs), a group of matrix-degrading enzymes. MMPs are regarded as promising therapeutic targets and the development of effective inhibitors is an important research focus. The plant Pothomorphe umbellata has been shown to exert a potent antioxidant activity on the skin and to delay the onset and reduce the incidence of UVB-induced chronic skin damage. The aim of the present study was to determine the effect of P. umbellata ethanolic root extract on MMP-2 and MMP-9. The in vitro inhibition of MMP-2 and MMP-9 was measured by gelatin zymography in the presence of different concentrations of P. umbellata extract, as well as in the presence of its isolated active principle 4-nerolidylcatechol (4-NC). The inhibitory effect of the P. umbellata extract was stronger than that of 4-NC. Gelatin zymography and histological analysis revealed that P. umbellata was able to inhibit constitutive MMP-9 activity in vivo in mice sacrificed 2 h after UVB irradiation. The intensity of the MMP-2 band was unchanged. Our data contribute to the elucidation of the mechanism of prevention of photoaging by P. umbellata and may provide a rational basis for the use of this plant in prophylaxis against and treatment of skin cancer.     

Modelling neuromuscular blockade: a stochastic approach based on clinical data

During surgical interventions, a muscle relaxant drug is frequently administered with the objective of inducing muscle paralysis. Clinical environment and patient safety issues lead to a huge variety of situations that must be taken into account requiring intensive simulation studies. Hence, population models are crucial for research and development in this field.

This work develops a stochastic population model for the neuromuscular blockade (NMB) (muscle paralysis) level induced by atracurium based on a deterministic individual model already proposed in the literature. To achieve this goal, a joint Lognormal distribution is considered for the patient-dependent parameters. This study is based on clinical data collected during general anaesthesia. The procedure developed enables to construct a reliable reference bank of parametrized models that not only reproduces the overall features of the NMB, but also the inter-individual variability characteristic of physiological signals. It turns out that this bank constitutes a fundamental tool to support research on identification and control algorithms and is suitable to be integrated in clinical decision support systems.