Complexes of the type
cis-[PdX
2(imzt)(PPh
3)] {imzt = imidazolidine-2-thione; PPh
3 = triphenylphosphine; X = Cl (
1), Br (
2), I (
3), SCN (
4)} have been synthesized and characterized by elemental analyses, molar conductance, IR and
1H NMR spectroscopies. The complex
1·MeOH was obtained from the reaction of [PdCl
2(CH
3CN)
2], imidazolidine-2-thione and triphenylphosphine in CHCl
3/CH
3OH. Complexes
2·MeOH,
3 and
4 were prepared by metathesis of the chlorido ligands in
1 with bromide, iodide and thiocyanate, respectively. Elemental analyses showed good agreement with the expected mononuclear compositions, while the molar conductivities of the complexes in DMF were consistent with their nonelectrolytic nature. NMR spectra confirmed coordination of the imidazolidine-2-thione and triphenylphosphine ligands. Single-crystal X-ray diffraction determination of
1·CH
3OH showed that the coordination geometry around Pd
II is nearly square planar, with the chlorido ligands in a
cis configuration. All four complexes have been tested in vitro by XTT assay for their cytotoxicity against human glioblastoma cell line (U87MG). The binding of
1 with guanosine was studied by
1H NMR spectroscopy, revealing that the coordination takes place via N7.
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