Benzindoles. 23. 2-formyl- and 3-formyl-4,5-benzindoles

It is shown that, in addition to the usually formed 3-formyl-4,5-benzindole, 2-formyl-4,5-benzindole can be obtained via the Vilsmeier reaction. The IR, PMR, and UV spectra of the 2- and 3-formyl isomers are compared, and their possible conformations are discussed.See [1] for Communication 22.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 343–345, March, 1984.     

Identification of impurities accumulated in the extractant in the course of purification of wet-process phosphoric acid with tri-<Emphasis Type="Italic">n</Emphasis>-butyl phosphate

Impurities accumulated in the extractant in the course of operation of the plant for purification of wet-process phosphoric acid, obtained from apatite concentrate, by extraction with tri-n-butyl phosphate are identified by IR and mass spectra.Translated from Zhurnal Prikladnoi Khimii, Vol. 77, No. 9, 2004, pp. 1425–1429.Original Russian Text Copyright © 2004 by Lembrikov, Konyakhina, Volkova, Perov, Kiseleva, Ershova.     

Multipeak distributions of first passage times in bistable dynamics in a model of a thermochemical system.

A master equation is used to study transitions between the stable limit cycle and stable focus in the two-variable bistable system. The distribution function of the mean first passage time between these attractors and the relative dispersion of the mean first return time from the stable focus to itself as a function of the intensity of fluctuations are calculated and discussed. A coherence resonance is observed for the return time from the focus to itself.     

Dipole moments,molar Kerr coefficients,and structures of certain substituted bicyclo[2, 2, 2] octenes and their epoxy derivatives

Russian Chemical Bulletin -     

The formation of filamentous structures from iodinated neurotubules.

The porcine neurotubule and its basic subunit were found to be modified in vitro by iodination of amino acids (principally tyrosine) using lactoperoxidase. Iodide ion, H2O2, or lactoperoxidase singly or in any pairwise combination had virtually no effect on neurotubules. However, when all three reagents were present, permitting covalent iodination, it was found that at 0.1 iodotyrosines per tubulin dimer the microtubules unravel to form structures which morphologically resemble strands of protofilaments twisted or wound around each other. These abnormal tubules are stable at room temperature and 4 degrees C. Both monomers of tubulin are labeled to approximately the same extent. Iodinated tubulin (0.1 iodotyrosines/dimer) is unable to assemble in vitro under normal assembly conditions. Heavily iodinated microtubules (8 iodines per tubulin dimer) are similar in morphology to the slightly iodinated structures.     

Phosphorylthioacetamides in the synthesis of annulated quinoxalines

Diethoxyphosphorylthioacetamide in the reaction with 2,3-dichloroquinoxaline acted as a thionating reagent, giving diethoxyphosphorylacetonitrile and 2-chloro-3-[(3-chloro-2-quinoxalinyl)thio]quinoxaline. Reactions of phosphorylthioacetamides with N-methylquinoxalinium iodide in alcohol media in the presence of a base proceeded stereoselectively to afford cis-3-phosphoryl-1,3,3a,4,9,9a-hexahydro-2H-pyrrolo[2,3-b]quinoxaline-2-thiones. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1010–1013, May, 2007.     

One-pot synthesis of 5-(substituted-amino)pyrazoles

An efficient and mild one-pot synthesis of substituted 5-alkylamino and/or 5-(arylamino)pyrazoles is described. A suitably decorated β-ketoamide, an aryl or alkyl hydrazine and Lawesson's reagent are suspended in THF/Py and gently heated to yield the requisite 5-aminopyrazoles.     

Analysis of ion binding on humic substances and the determination of intrinsic affinity distributions

Humic substances are characterized by a variable electric potential and by a variety of binding sites leading to chemical heterogeneity. Binding of ions to these substances is influenced by both factors. A methodology based on acid—base titrations at several salt levels is presented that allows for the assessment of an appropriate electrostatic double-layer model and the intrinsic proton affinity distribution. The double-layer model is used for the conversion of pH to pH_S for each data point, where H_S is the proton concentration in the diffuse layer near the binding site. It is shown that with an appropriate double-layer model the proton binding curves at different salt levels converge into one “master curve” when plotted as a function of pH_S. The intrinsic proton affinity distribution can then be derived from the “master curve” using the LOGA method. A rigorous analysis of metal binding to humic substances is complex and in practice is not feasible. Under two different (simplifying) assumptions, namely fully coupled and uncoupled binding, it is shown how intrinsic metal ion affinity distributions can be obtained. Model calculations show that apparent metal ion affinity distributions do not resemble the intrinsic metal ion affinity distribution.     

Isolation of nonprotamine proteins from the nuclei of the gonad cells of the Russian sturgeonAcipenser güldenstadti

Eight nonprotamine proteins have extracted from the nuclei of the cells of the gonads of the Russian sturgeon with 0.35 M sodium chloride solution followed by fractionation of carboxymethyl-Sephadex G-25 and desalting on Bio-Gel P-2, and their amino acid compositions have been determined.