Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea

Rosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, including calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal peptide, which can activate macrophage and inflammatory molecules. In this study, we found that radiofrequency (RF) irradiation reduced TRPV1 activation and neuropeptide expression in a UVB-exposed in vivo model and UVB- or heat-treated in an in vitro model. RF irradiation attenuated neuropeptide-induced macrophage activation and inflammatory molecule expression. Interestingly, the burning sensation in the skin of UVB-exposed mice and patients with rosacea was significantly decreased by RF irradiation. These results can provide experimental and molecular evidence on the effective use of RF irradiation for the burning sensation in patients with rosacea.     

Global $$C^{1,\al pha }$$ regularity and e xistence of multi ple solutions for singular p( x)-La placian equations

In this paper we study the following singular p(x)-Laplacian problem

$$\begin{aligned} \left\{ \begin{array}{l@{\quad }l} - \text{ div } \left( |\nabla u|^{p(x)-2} \nabla u\right) =\frac{ \lambda }{u^{\beta (x)}}+u^{q(x)}, &{} \text{ in }\quad \Omega , \\ u>0, &{} \text{ in }\quad \Omega , \\ u=0, &{} \text{ on }\quad \partial \Omega , \end{array}\right. \end{aligned}$$

where \(\Omega \) is a bounded domain in \(\mathbb {R}^N\), \(N\ge 2\), with smooth boundary \(\partial \Omega \), \(\beta \in C^1(\bar{\Omega })\) with \( 0< \beta (x) <1\), \(p\in C^1(\bar{\Omega })\), \(q \in C(\bar{\Omega })\) with \(p(x)>1\), \(p(x)< q(x) +1 <p^*(x)\) for \(x \in \bar{\Omega }\), where \( p^*(x)= \frac{Np(x)}{N-p(x)} \) for \(p(x) <N\) and \( p^*(x)= \infty \) for \( p(x) \ge N\). We establish \(C^{1,\alpha }\) regularity of weak solutions of the problem and strong comparison principle. Based on these two results, we prove the existence of multiple (at least two) positive solutions for a certain range of \(\lambda \).

     

Nonlinear elliptic equations with BMO coefficients in Reifenberg domains

We develop a unifying method to obtain the interior and boundary estimates for the weak solution of a nonlinear elliptic partial differential equation of p-Laplacian type with BMO coefficients in a δ-Reifenberg flat domain. Our results greatly improve the known results for such equations.     

Experimental study of sensitivity enhancement in surface plasmon resonance biosensors by use of periodic metallic nanowires

We have experimentally confirmed sensitivity enhancement of a nanowire-based surface plasmon resonance (SPR) sensor structure. Gold nanowires with periods of 200 and 500 nm were fabricated, respectively, by electron-beam and interference lithography on a gold/SF10 substrate. Sensitivity enhancement was measured to be 44% compared with a conventional thin-film-based SPR structure for nanowires of 200 nm period and 31% for 500 nm when evaluated using ethanol at a varied concentration. This result is consistent with numerical data. Surface roughness is responsible for sensitivity reduction by more than 10%. More significant sensitivity improvement can be achieved by inducing strong localized plasmon coupling with finer nanowires.     

A Three‐Dimensional Porous Organic Semiconductor Based on Fully sp2‐Hybridized Graphitic Polymer

Dimensionality plays an important role in the charge transport properties of organic semiconductors. Although three‐dimensional semiconductors, such as Si, are common in inorganic materials, imparting electrical conductivity to covalent three‐dimensional organic polymers is challenging. Now, the synthesis of a three‐dimensional π‐conjugated porous organic polymer (3D p‐POP) using catalyst‐free Diels–Alder cycloaddition polymerization followed by acid‐promoted aromatization is presented. With a surface area of 801 m² g^?1, full conjugation throughout the carbon backbone, and an electrical conductivity of 6(2)×10^?4 S cm^?1 upon treatment with I₂ vapor, the 3D p‐POP is the first member of a new class of permanently porous 3D organic semiconductors.     

Radiofrequency Irradiation Mitigated UV-B-Induced Skin Pigmentation by Increasing Lymphangiogenesis

Dermal macrophages containing melanin increase skin pigmentation since dermal melanin removal is slower than epidermal melanin removal. Lymphatic vessels are also involved in melanin clearance. We evaluated whether radiofrequency (RF) irradiation induced an increase in HSP90, which promotes lymphangiogenesis by activating the BRAF/MEK/ERK pathway and decreasing tyrosinase activity, in the UV-B exposed animal model. The HSP90/BRAF/MEK/ERK pathway was upregulated by RF. Tyrosinase activity and the VEGF-C/VEGFR 3/PI3K/pAKT1/2/pERK1/2 pathway, which increase lymphangiogenesis, as well as the expression of the lymphatic endothelial marker LYVE-1, were increased by RF. Additionally, the number of melanin-containing dermal macrophages, the melanin content in the lymph nodes, and melanin deposition in the skin were decreased by RF. In conclusion, RF increased HSP90/BRAF/MEK/ERK expression, which decreased tyrosinase activity and increased lymphangiogenesis to eventually promote the clearance of dermal melanin-containing macrophages, thereby decreasing skin pigmentation.     

Low-temperature growth of GaN by atomic nitrogen based on a dielectric barrier discharge

GaN films were deposited on sapphire(0 0 0 1) and Si(1 0 0) substrates by MOCVD using an atomic nitrogen source based on a dielectric barrier discharge (DBD) method. Molecule nitrogen and trimethylgallium (TMG) were separately delivered to the substrates. Wurtzite GaN films, with no trace of cubic GaN, were successfully grown on -Al₂O₃ substrates even at relatively low temperatures (<800°C). Sapphire substrate RMS roughness was 5.01 and 4.93 Å before and after the exposure to DBD N-source, respectively. This shows negligible irradiation damage of accelerated N₂⁺ ion as well as the effect of smoothening the substrate surfaces with DBD N-source. The PL results exhibited small luminescence at the spectral region of blue and UV but a luminescence around the yellow region (2.5 eV) was detected. This is caused by oxygen impurity from AES analysis.     

Small-ring heterocycles as components of multidentate ligands: some structural studies relating to ring opening

Structural studies of seven complexes of ligands derived from various azetidine- and oxetane-containing ligands characterise the difference in reactivity of both free and bound forms of these two four-membered heterocycles. The relatively unreactive azetidine ring is preserved in a variety of transformations, whereas facile opening of the oxetane ring provides a convenient pathway to complexes with pendent functionality.