The influence of Lewis acid catalyst on the kinetic and molecular mechanism of nitrous acid elimination from 5-nitro-3-phenyl-4,5-dihydroisoxazole: DFT computational study

Chemistry of Heterocyclic Compounds - The molecular mechanism of nitrous acid elimination from 5-nitro-3-phenyl-4,5-dihydroisoxazole systems has been explored using DFT computational study. It was...     

Analysis of Cibacron blue F3G-A interaction with therapeutic proteins by MALDI-TOF mass spectrometry

The formation of the complexes between Cibacron blue F3G-A and two therapeutic proteins, recombinant human interferon-alpha2b and recombinant human growth hormone, was investigated. The method of time-resolved limited proteolysis coupled with MALDI-TOF mass spectrometry was used. The analysis of peptide maps revealed that A(17)HR(19) and L(20)HQLAFDTYQEFEEAYIPK(38) of hGH, and R(14)TLMLLAQMR(23) and D(33)RHDFGFPQEEFGNQFQK(50) of hIFN-alpha2b, exhibit affinity to Cibacron blue F3G-A. Copyright (c) 2008 John Wiley & Sons, Ltd.     

Separating sets by lower and upper semicontinuous functions with a closed graph

In this paper we characterize the pairs (A^?, A⁺) of disjoint subsets of perfectly normal topological space which can be separated by a lower and an upper semicontinuous function with a closed graph.     

Phytochemical profile and therapeutic potential of Viscum album L.

Viscum album L., the European mistletoe, is a common species from the Viscaceae family. This evergreen hemiparasitic shrub grows on various trees and contains diverse, biologically active substances. Its chemical composition may vary depending on the time of harvest, species of the host tree and the manufacturing process. Among well-described and most active phytochemicals identified in V. album are lectins and viscotoxins, which play substantial role in cancer treatment because of their apoptotic and cytotoxic effects. Another group of compounds found in mistletoe are phenolic acids, phenylpropanoids and flavonoids with antioxidant and anti-inflammatory activities, which decrease blood pressure. Other mistletoe components include, among others, triterpenes with cytotoxic and apoptotic properties, and phytosterols, oligo- and polysaccharides. Extracts from the plant, especially aqueous, are applied in traditional and official medicine, among others in treating hypertension or arthritis. Potentially, it can also be used as a hepatoprotective or a sedative drug.     

Hyperstability of general linear functional equation

Our purpose is to investigate criteria for hyperstability of linear type functional equations. We prove that a function satisfying the equation approximately in some sense, must be a solution of it. We give some conditions on coefficients of the functional equation and a control function which guarantee hyperstability. Moreover, we show how our outcomes may be used to check whether the particular functional equation is hyperstable. Some relevant examples of applications are presented.     

Quantitative comparison of selectivities in the polymerization of cyclic esters

Chain transfer processes (k_tr) taking place in the polymerization (anionic and pseudoanionic) of cyclic esters (lactones) are reviewed. These reactions are mostly responsible for the departure of these systems from the fully controlled (living) polymerizations. The ratios of k_p/k_tr have been determined for a number of initiating systems and the structures of the growing species are related to their selectivity, expressed by k_p/k_tr. It has been shown that the less reactive and more sterically crowded active species polymerize more selectively.     

Tosylated glycerol carbonate, a versatile bis-electrophile to access new functionalized glycidol derivatives

The reactivity of tosylated glycerol carbonate 2 toward nucleophiles has been exploited to generate glycidol analogues protected with carbonate or carbamate groups. The activated glycerol 2 is a reasonable linking agent with thiol and alcohol nucleophiles and an excellent and selective one with primary amines, allowing efficient bis-functionalizations of glycerol.