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Andreas Johann 《Journal of Differential Equations》2002,184(1):224-258
We investigate stationary and travelling wave solutions of a special lattice differential equation in one space dimension. Depending on a parameter λ, results are given on the existence, shape and stability for these kind of solutions. The analysis of travelling wave solutions leads us to a functional differential equation with both forward and backward shifts. The existence of solutions of this equation will be proved by use of the implicit function theorem. In particular, we consider kink solutions and periodic solutions. 相似文献
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Johann Radon 《Monatshefte für Mathematik》1911,22(1):53-63
Ohne Zusammenfassung 相似文献
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We propose the new concept of a switchable multimode microlaser. As a generic, realistic model of a multimode microresonator a system of two coupled defects in a two-dimensional photonic crystal is considered. We demonstrate theoretically that lasing of the cavity into one selected resonator mode can be caused by injecting an appropriate optical pulse at the onset of laser action (injection seeding). Temporal mode-to-mode switching by reseeding the cavity after a short cooldown period is demonstrated by direct numerical solution. A qualitative analytical explanation of the mode switching in terms of the laser bistability is presented. 相似文献
139.
Design and Synthesis of High‐Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors
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Dr. Hans Michael Maric Vikram Babu Kasaragod Dr. Linda Haugaard‐Kedström Dr. Torben Johann Hausrat Prof. Dr. Matthias Kneussel Prof. Dr. Hermann Schindelin Prof. Dr. Kristian Strømgaard 《Angewandte Chemie (International ed. in English)》2015,54(2):490-494
Gephyrin is the central scaffolding protein for inhibitory neurotransmitter receptors in the brain. Here we describe the development of dimeric peptides that inhibit the interaction between gephyrin and these receptors, a process which is fundamental to numerous synaptic functions and diseases of the brain. We first identified receptor‐derived minimal gephyrin‐binding peptides that displayed exclusive binding towards native gephyrin from brain lysates. We then designed and synthesized a series of dimeric ligands, which led to a remarkable 1220‐fold enhancement of the gephyrin affinity (KD=6.8 nM ). In X‐ray crystal structures we visualized the simultaneous dimer‐to‐dimer binding in atomic detail, revealing compound‐specific binding modes. Thus, we defined the molecular basis of the affinity‐enhancing effect of multivalent gephyrin inhibitors and provide conceptually novel compounds with therapeutic potential, which will allow further elucidation of the gephyrin–receptor interplay. 相似文献
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Christian Wenz Coral Barbas Ángeles López‐Gonzálvez Antonia Garcia Fernando Benavente Victoria Sanz‐Nebot Tim Blanc Gordon Freckleton Philip Britz‐McKibbin Meera Shanmuganathan Francois de l′Escaille Johann Far Rob Haselberg Sean Huang Carolin Huhn Martin Pattky David Michels Si Mou Feng Yang Christian Neusuess Nora Tromsdorf Edward E.K. Baidoo Jay D. Keasling SungAe Suhr Park 《Journal of separation science》2015,38(18):NA-NA
A collaborative study on the robustness and portability of a capillary electrophoresis‐mass spectrometry method for peptide mapping was performed by an international team, consisting of 13 independent laboratories from academia and industry. All participants used the same batch of samples, reagents and coated capillaries to run their assays, whereas they utilized the capillary electrophoresis‐mass spectrometry equipment available in their laboratories. The equipment used varied in model, type and instrument manufacturer. Furthermore, different types of sheath‐flow capillary electrophoresis–mass spectrometry interfaces were used. Migration time, peak height and peak area of ten representative target peptides of trypsin‐digested bovine serum albumin were determined by every laboratory on two consecutive days. The data were critically evaluated to identify outliers and final values for means, repeatability (precision within a laboratory) and reproducibility (precision between laboratories) were established. For relative migration time the repeatability was between 0.05 and 0.18% RSD and the reproducibility between 0.14 and 1.3% RSD. For relative peak area repeatability and reproducibility values obtained were 3–12 and 9–29% RSD, respectively. These results demonstrate that capillary electrophoresis‐mass spectrometry is robust enough to allow a method transfer across multiple laboratories and should promote a more widespread use of peptide mapping and other capillary electrophoresis‐mass spectrometry applications in biopharmaceutical analysis and related fields. 相似文献