全文获取类型
收费全文 | 1491篇 |
免费 | 70篇 |
国内免费 | 5篇 |
专业分类
化学 | 1278篇 |
晶体学 | 5篇 |
力学 | 13篇 |
数学 | 108篇 |
物理学 | 162篇 |
出版年
2024年 | 2篇 |
2023年 | 3篇 |
2022年 | 57篇 |
2021年 | 97篇 |
2020年 | 37篇 |
2019年 | 39篇 |
2018年 | 33篇 |
2017年 | 35篇 |
2016年 | 65篇 |
2015年 | 50篇 |
2014年 | 58篇 |
2013年 | 106篇 |
2012年 | 120篇 |
2011年 | 131篇 |
2010年 | 67篇 |
2009年 | 68篇 |
2008年 | 96篇 |
2007年 | 98篇 |
2006年 | 64篇 |
2005年 | 86篇 |
2004年 | 61篇 |
2003年 | 37篇 |
2002年 | 42篇 |
2001年 | 6篇 |
2000年 | 11篇 |
1999年 | 9篇 |
1998年 | 7篇 |
1997年 | 8篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1984年 | 5篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1967年 | 2篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1962年 | 2篇 |
排序方式: 共有1566条查询结果,搜索用时 31 毫秒
101.
Joanna Taraszewska Magorzata Ko
bia 《Journal of inclusion phenomena and macrocyclic chemistry》2005,53(3):155-161
Complexation of ketoconazole (KET), a broad-spectrum antifungal drug, with β- and γ-cyclodextrins (CDs), heptakis (2,6-di-O-methyl)-β-CD (2,6-DM-β-CD), heptakis (2,3,6-tri-O-methyl)-β-CD (TM-β-CD), 2-hydroxypropyl-β-CD (2HP-β-CD) and carboxymethyl-β-CD (CM-β-CD) was studied. The stability constants were determined by the solubility method at pH = 6 and for 2,6-DM-β-CD and CM-β-CD at pH = 5. At pH = 6, the stability constants increased in the order: TM-β-D < γ-CD < 2HP-β-CD < β-CD < CM-β-CD < 2,6-DM-β-CD. At pH = 5, due to the increased ionization of KET, the stability constant with CM-β-CD increased and with 2,6-DM-β-CD decreased. For complexes of KET with 2HP-β-CD and 2,6-DM-β-CD, the thermodynamic parameters of complexation were determined from the temperature dependence of the corresponding stability constants. For β–γ and TM-β-CD complexes, calculations using HyperChem 6 software by the Amber force field were carried out to gain some insight into the host–guest geometry. 相似文献
102.
Duncan G. Wynn Gareth HumphriesVéronique Morisson-Iveson James NairneIan M. Newington Joanna PassmoreLars-Göran Wistrand 《Tetrahedron letters》2011,52(24):3068-3071
Novel dimeric iodinated contrast agents with low osmolality have been prepared and evaluated with the aim of improving the already good safety profile of such agents. The aim of low osmolality was achieved, and the viscosity of these dimeric agents was also found to be beneficially lower than current dimeric agents in clinical use. 相似文献
103.
104.
105.
106.
107.
A three-dimensional liquid chromatographic purification protocol based on sequential size-exclusion, anion-exchange and cation-exchange separation mechanisms was developed for the mapping of seleno compounds in aqueous yeast extracts. The method allowed the demonstration of the presence of more than 30 different seleno compounds. Semi-preparative size-exclusion and anion-exchange chromatography were optimized for maximum resolution using electrospray-compatible buffers in order to purify the compounds for mass spectrometric analysis. Molecular masses were attributed to many of the compounds on the basis of the selenium isotopic pattern in the electrospray mass spectra and of the collision-induced fragmentation patterns. Limitations preventing the ultimate identification of the selenium species detected are discussed. 相似文献
108.
Bacteriochlorophyll (BChl) derivatives (with central Mg replaced by metal "M") ([M]-BChl with M = 2H, Mg, Zn, Pd, Cu) have been investigated for their photodynamic capacity and stability toward photodegradation in organic solvents and aqueous micellar solution. A protocol has been developed for screening new sensitizers. BChl and [Zn]-BChl are efficient sensitizers, but they are also quickly degraded by the reactive oxygen species (ROS) produced by autosensitization, as well as by hetero-sensitization with 17(4)-methyl-13(2)-demethoxycarbonyl-pheophorbide a (MPP). Photostable [Cu]-BChl is a poor sensitizer, whereas [Pd]-BChl and bacteriopheophytin a are not only very efficient sensitizers but are also very stable toward ROS. beta-Carotene is no efficient physical quencher of ROS in the system; rather, it acts as a photochemical quencher that competes with [M]-BChl and undergoes photooxygenation at high rates. Photolability seems to depend on the pigment oxidation potential and, in parallel, on the presence of central metals preferring coordination numbers higher than 4, whereas photodynamic capacity depends on long excited state life-times of the pigment or efficient intersystem crossing (or both). 相似文献
109.
110.
Helen?BarbasEmail author Claus?C?Hilgetag Subhash?Saha Caterina?R?Dermon Joanna?L?Suski 《BMC neuroscience》2005,6(1):32