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11.
[reaction: see text] Pi-deficient heteroaromatic thioethers undergo efficient palladium-catalyzed cross-coupling with boronic acids mediated by copper(I) thiophene-2-carboxylate. 相似文献
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Dr. Tana Koudelakova Dr. Radka Chaloupkova Dr. Jan Brezovsky Dr. Zbynek Prokop Dr. Eva Sebestova Dr. Martin Hesseler Dr. Morteza Khabiri Maryia Plevaka Daryna Kulik Dr. Ivana Kuta Smatanova Dr. Pavlina Rezacova Dr. Rudiger Ettrich Prof. Uwe T. Bornscheuer Prof. Jiri Damborsky 《Angewandte Chemie (International ed. in English)》2013,52(7):1959-1963
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The effect of cationic and anionic surfactants, as well as cationic and anionic polyelectrolytes (PE), their binary mixtures on the electrokinetic potential of monodisperse carboxylated polystyrene (PS) particles as a function of the reagents dose, pH, the charge density (CD) of polymers, the surfactant/PE and binary PE mixture composition, and sequence of components addition to the suspension has been studied. It has been shown that addition of increasing amount of anionic surfactant/polyelectrolytes increases the absolute value of the negative zeta-potential of PS particles; this increase is stronger the CD of the PE and pH of the system are higher. Adsorption of cationic surfactant/polyelectrolytes leads to a significant decrease in the negative ζ-potential and to overcharging the particles; changes in the ζ-potential are more pronounced for PE samples with higher CD and for suspensions with lower pH values. In mixtures of cationic and anionic PE, in a wide range of mixture composition, the ζ-potential of particles is determined by the adsorbed amount of the anionic polymer independently of the CD of PEs and the sequence of addition of the mixture components. The isoelectric point of the surface is reached at the adsorbed amount of positive charges of PE that is approximately equal to the surface CD of particles. The laws observed were explained by features of macromolecules conformation in adsorbed mixed PE layers. Considerations about the role of coulombic and non-coulombic forces in the mechanism of anionic/cationic PE adsorption are presented. 相似文献
15.
Grace Mugumbate Ana S. Newton Philip J. Rosenthal Jiri Gut Rui Moreira Kelly Chibale Rita C. Guedes 《Journal of computer-aided molecular design》2013,27(10):859-871
Increased resistance of Plasmodium falciparum to most available drugs challenges the control of malaria. Studies with protease inhibitors have suggested important roles for the falcipain family of cysteine proteases. These enzymes act in concert with other proteases to hydrolyze host erythrocyte hemoglobin in the parasite food vacuole. In order to find potential new antimalarial drugs, we screened in silico the ZINC database using two different protocols involving structure- and ligand-based methodologies. Our search identified 19 novel low micromolar inhibitors of cultured chloroquine resistant P. falciparum. The most active compound presented an IC50 value of 0.5 μM against cultured parasites and it also inhibited the cysteine protease falcipain-2 (IC50 = 25.5 μM). These results identify novel classes of antimalarials that are structurally different from those currently in use and which can be further derivatized to deliver leads suitable for optimisation. 相似文献
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Sylvie Skalickova Pavel Horky Veronika Mlejnkova Jiri Skladanka Bozena Hosnedlova Branislav Ruttkay‐Nedecky Carlos Fernandez Rene Kizek 《Chemical record (New York, N.Y.)》2021,21(1):17-28
Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non‐toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano‐bio interactions and discover new connections in nanoscale research. 相似文献
17.
We report on the photoelectrochemical and terahertz measurements, of the charge transport properties of 1 μm thick self‐organized TiO2 nanotube layers, prepared by the anodization of titanium. We provide evidence regarding the complexity of electron transport, and dynamics in the nanotubes. Shortly after photoexcitation, charge mobilites in amorphous and crystalline nanotubes are similar, but still lower compared to the bulk anatase. The mobility subsequently decreases due to trapping‐detrapping processes. The recombination rate in anatase nanotubes is much slower than in the amorphous ones, enabling the material to reach an internal photon to electron conversion efficiency exceeding 60%. 相似文献
18.
Jiri Ullschmied 《辐射效应与固体损伤》2015,170(4):278-289
The Prague Asterix Laser System (PALS) Research Infrastructure (RI) in Prague, one of only four kJ-class laser facilities in EU, has been offering its beam time to European researchers for already 14 years, since 2004 in the framework of the LASERLAB-Europe consortium. Till June 2014, the PALS RI has provided 4313 experimental days for a total of 41 projects with 303 international users from 42 different research institutions. Its principal experimental facility is a terawatt sub-ns iodine laser (1315?nm) with an optional plasma-based zinc XUV laser (21.2?nm), and an auxiliary Ti:Sapphire fs laser (1?J, 70?fs) exploited for femtosecond plasma probing and experiments with synchronised femtosecond and sub-nanosecond laser pulses at mean laser intensities of up to 30?PW/cm2. The lasers are equipped with several target facilities and rich sets of instruments for both active and passive plasma diagnostics. The PALS main research areas include development and applications of secondary laser sources of high-energy ions and both coherent and non-coherent high-intensity XUV radiation, laboratory astrophysical and inertial fusion-relevant studies. In this paper, the main results having been achieved at PALS in the framework of LASERLAB-EUROPE international access activities during the last four years are highlighted. 相似文献
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Dr. Kaori Fujisawa Dr. César Beuchat Marie Humbert‐Droz Dr. Adam Wilson Prof. Tomasz A. Wesolowski Dr. Jiri Mareda Dr. Naomi Sakai Prof. Stefan Matile 《Angewandte Chemie (International ed. in English)》2014,53(42):11266-11269
Herein, we address the question whether anion–π and cation–π interactions can take place simultaneously on the same aromatic surface. Covalently positioned carboxylate–guanidinium pairs on the surface of 4‐amino‐1,8‐naphthalimides are used as an example to explore push–pull chromophores as privileged platforms for such “ion pair–π” interactions. In antiparallel orientation with respect to the push–pull dipole, a bathochromic effect is observed. A red shift of 41 nm found in the least polar solvent is in good agreement with the 70 nm expected from theoretical calculations of ground and excited states. Decreasing shifts with solvent polarity, protonation, aggregation, and parallel carboxylate–guanidinium pairs imply that the intramolecular Stark effect from antiparallel ion pair–π interactions exceeds solvatochromic effects by far. Theoretical studies indicate that carboxylate–guanidinium pairs can also interact with the surfaces of π‐acidic naphthalenediimides and π‐basic pyrenes. 相似文献