Oxidative Dehydrogenative Silylation‐Alkenation Reaction of Alkyl Aromatics with Silanes

A Cu(OAc)₂/DDQ/DTBP/Py system catalyzed oxidative dehydrogenative silylation‐alkenation tandem reaction of readily available alkyl aromatic compounds with silanes was established. A variety of functionalized alkenyl organosilicon compounds were provided in good to high yields with a total β‐(E) selectivity. The control experiments revealed that the transformation might proceed through a radical pathway.     

Metal–Organic Frameworks as Metal Ion Precursors for the Synthesis of Nanocomposites for Lithium‐Ion Batteries

Metal–organic frameworks (MOFs) are promising materials with fascinating properties. Their widespread applications are sometimes hindered by the intrinsic instability of frameworks. However, this instability of MOFs can also be exploited for useful purposes. Herein, we report the use of MOFs as metal ion precursors for constructing functional nanocomposites by utilizing the instability of MOFs. The heterogeneous growth process of nanostructures on substrates involves the release of metal ions, nucleation on substrates, and formation of a covering structure. Specifically, the synthesized CoS with carbon nanotubes as substrates display enhanced performance in a lithium‐ion battery. Such strategy not only presents a new way for exploiting the instability of MOFs but also supplies a prospect for designing versatile functional nanocomposites.     

Fluevirines E and F,two new alkaloids from Flueggea virosa

Abstract

Two new alkaloids, fluevirines E (1) and F (2), along with six known Securinega alkaloids, were isolated from the methanol extract of the twigs and leaves of Flueggea virosa. The structures and absolute configurations of the new compounds were elucidated by means of MS, NMR, and ECD analyses. Compound 1 is a new dimeric indole alkaloid while 2 is a new securinega-type alkaloid. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines and their acetylcholinesterase inhibitory activity were also evaluated.     

Benzophenone glycosides from the pericarps of Aquilaria yunnanensis S. C. Huang

Abstract

Two new benzophenone glycosides, aquilarisides A (1) and B (2), together with six known analogues (3-8) were isolated from the pericarps of Aquilaria yunnanensis S. C. Huang. Their structures were elucidated on the basis of 1D and 2D NMR and mass spectroscopic analyses, and the absolute configuration of compound 1 was determined by experimental and calculated electronic circular dichroism (ECD) spectra. Anti-inflammatory activities of all compounds 1–8 were evaluated for their inhibitory activities against lipopolysaccharide (LPS)-stimulated induced nitric oxide (NO) production in RAW 264.7 cells using the Griess assay. Compound 2 indicated a weak inhibition of NO production.     

Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cells

Herein, we report on the design of a programmable DNA ribbon using long‐chain DNA molecules with a user‐defined repetitive padlock sequence. The DNA ribbon can be further combined with gold nanoparticles (AuNPs) to create a composite nanomaterial that contains an AuNP core and a high‐density DNA crown carrying a cancer‐cell‐targeting DNA aptamer, a fluorescent tag for location tracking, and a cell‐killing drug. This composite material can be efficiently internalized by cancer cells and its cellular location can be tracked by fluorescence imaging. The system offers several attractive characteristics, including simple design, tunable DNA crown, high drug‐loading capacity, selective cell targeting, and pH‐sensitive drug release. These features make such a material a promising therapeutic agent.     

（FeCp2）0．65FNi（C3S7）2]的合成及表征

合成了一种新型的导电配位型化合物（FeCp2）0．65FNi（C3S7）2].通过元素分析（EA），电感耦合等离子体原子发射光谱（ICP—AES），核磁共振（^1HNMR），紫外光谱（UV）对该化合物进行了表征。     

Building 2D classification models and 3D CoMSIA models on small-molecule inhibitors of both wild-type and T790M/L858R double-mutant EGFR

Molecular Diversity - Epidermal growth factor receptor (EGFR) has received widespread attention because it is an important target for anticancer drug design. Mutations in the EGFR, especially the...     

A wide dynamic range laser rangefinder with cm-level resolution based on AGC amplifier structure

A pulsed time-of-flight (TOF) laser rangefinder with a pulsed laser diode and an avalanche photo diode (APD) receiver is constructed and tested. Trigged by an avalanche transistor, the laser diode can emit a periodic pulse with rise time of ～2 ns. A new structure with auto gain control (AGC) circuits both in the pre-amplifier and the post-amplifier is presented. Through this technology, not only the dynamic range of the receiver is extended, but also the walk error of timing discriminators is reduced. Large measurement range from 5 m to 500 m is achieved without any cooperative target. The single-shot precision is 3 cm for the weakest signal. Compared with previous laser rangefinders, the complexity of this system is greatly simplified.