全文获取类型
收费全文 | 49986篇 |
免费 | 9290篇 |
国内免费 | 6319篇 |
专业分类
化学 | 36038篇 |
晶体学 | 632篇 |
力学 | 3045篇 |
综合类 | 450篇 |
数学 | 5633篇 |
物理学 | 19797篇 |
出版年
2024年 | 124篇 |
2023年 | 993篇 |
2022年 | 1569篇 |
2021年 | 1835篇 |
2020年 | 2180篇 |
2019年 | 2129篇 |
2018年 | 1800篇 |
2017年 | 1664篇 |
2016年 | 2469篇 |
2015年 | 2400篇 |
2014年 | 3052篇 |
2013年 | 3804篇 |
2012年 | 4594篇 |
2011年 | 4811篇 |
2010年 | 3244篇 |
2009年 | 3169篇 |
2008年 | 3499篇 |
2007年 | 3059篇 |
2006年 | 2879篇 |
2005年 | 2308篇 |
2004年 | 1842篇 |
2003年 | 1424篇 |
2002年 | 1429篇 |
2001年 | 1174篇 |
2000年 | 935篇 |
1999年 | 1006篇 |
1998年 | 829篇 |
1997年 | 815篇 |
1996年 | 763篇 |
1995年 | 655篇 |
1994年 | 565篇 |
1993年 | 431篇 |
1992年 | 393篇 |
1991年 | 349篇 |
1990年 | 307篇 |
1989年 | 221篇 |
1988年 | 166篇 |
1987年 | 144篇 |
1986年 | 153篇 |
1985年 | 107篇 |
1984年 | 68篇 |
1983年 | 71篇 |
1982年 | 54篇 |
1981年 | 39篇 |
1980年 | 23篇 |
1979年 | 7篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1959年 | 5篇 |
1957年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
41.
Youchao Wang Na Tian Weize Sun Boerhan Rena Xusheng Guo Yang Feng Chao Li Xuesong Wang Qianxiong Zhou 《Particle & Particle Systems Characterization》2020,37(5):2000045
Photoactivated chemotherapy (PACT) has appealing merits over traditional chemotherapy as well as photodynamic therapy (PDT) by virtue of its spatial and temporal control on drug activity and oxygen-independent mechanisms of action. However, the short photoactivation wavelengths, e.g., visible light–activated Ru(II)-based PACT agents, limit the clinical application severely. In this work, a facile construction of supramolecular nanoparticles from a poly(ethylene glycol) (PEG)-modified [Ru(dip)2(py-SO3)]+ (abbreviated as Ru-PEG, dip = 4,7-diphenyl-1,10-phenanthroline, py-SO3 = pyridine-2-sulfonate) and 1,3-phenylenebis(pyren-1-ylmethanone) (BP) is shown. While Ru-PEG may undergo photoinduced ligand dissociation and release anticancer species of [Ru(dip)2(H2O)2]2+, BP has extremely large two-photon absorption cross sections (δ2) in the NIR region and intense fluorescence over the wavelengths where Ru-PEG has strong absorption. Thus, two-photon excitation of BP followed by an efficient Förster resonance energy transfer (FRET) from BP to Ru-PEG may lead to a potent inactivation against cisplatin-resistant cancer cells and 3D multicellular tumor spheroids (MCTSs). The residue fluorescence of BP also allows the cellular uptake of the particles to be visualized. This work provides a universal and convenient strategy to realize theranostic PACT in the ideal phototherapeutic window of 650–900 nm. 相似文献
42.
43.
Hui Li Jian Liu Juan Zhao Huiting He Dr. Dabo Jiang Prof. Steven Robert Kirk Prof. Qiong Xu Dr. Xianxiang Liu Prof. Dulin Yin 《ChemistryOpen》2021,10(4):477-485
A series of tetraimidazolium salts with different anions was prepared and applied in the isomerization of β-pinene oxide. After examining the activity of different catalysts, a remarkable enhancement of the selectivity of perillyl alcohol (47 %) was obtained over [PEimi][HNO3]4 under mild reaction conditions and using DMSO as the solvent. Furthermore, noncovalent interactions between solvent molecules and the catalyst were found by FT-IR spectroscopy and confirmed by computational chemistry. The homogeneous catalyst showed excellent stability and was reused up to six times without significant loss. 相似文献
44.
Liying Zhang Chuanrui Zhao Yujiao Bai Qian Wang Pan Ma Xiaojie Ma Peihua Zhu 《Electroanalysis》2022,34(2):302-309
The design and exploration of efficient, stable and environmentally compatible organic emitters for an electrochemiluminescence (ECL) sensor is a promising topic. Herein, a novel environmentally-friendly luminophore, ZnBCBTP@MWCNTs, were fabricated via self-assembly of porphyrin molecules (ZnBCBTP) onto multi-walled carbon nanotubes (MWCNTs). The resulting luminophore ZnBCBTP@MWCNTs displayed not only the highly ECL property and but also the good accelerated electron mobility. Then, a label-free ECL biosensor based ZnBCBTP@MWCNTs was constructed for the ultrasensitive detection of uric acid. Excitingly, this proposed ECL biosensor performed a good linear relationship in the range of 0–300 μM with a low detection limit of 1.4 μM, thus offering another reliable and feasible sensing platform for clinical bioanalysis with good selectivity, stability, and repeatability. 相似文献
45.
Effect of the dispersion on multipartite continuous-variable entanglement in optical parametric amplifier
下载免费PDF全文
![点击此处可从《中国物理 B》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Based on the quantum fluctuations, we adopt the method of generalized V1 criterion to investigate multipartite entanglement characteristics in an optical parametric amplification system with the consideration of dispersion. The nonlinear interaction becomes strong because of the existence of dispersion coefficient σ. Considering the influence of dispersion factor σ, with increasing the pump parameter μ, the value of minimum variance V1 decreases and the squeezing curve nearly equals 1/(1 + μ). The larger particle number N results in a smaller variance and higher entanglement. 相似文献
46.
47.
Liming Fan Feng Wang Dongsheng Zhao Yuxin Peng Yuxin Deng Yinwei Luo Xiutang Zhang 《应用有机金属化学》2020,34(12):e5960
Guided by the self-penetrating features can improve the stability of metal organic frameworks (MOFs), an unprecedented 3D self-penetrated framework, {[Zn (tptc)0.5(bimb)]·H2O}n ( NUC-6 , here NUC corresponding to North University of China), with 3D (4,4)-c {86} net, was designed. Benefit from the high chemical stability and excellent luminescent property, NUC-6 can be act as an efficient multi-response chemo-sensor in detecting dichloronitroaniline pesticide and nitrofuran antibiotics in water with the detection limits are 116 ppb for DCN pesticide, 16 ppb for NFT antibiotic, and 12 ppb for NTZ antibiotic. Besides, the mechanisms of luminescence quenching were revealed from the viewpoint of internal filter effect (IFE) and photo-induced electron transfer (PET), implied by the optical spectroscopy and quantum chemical calculation. This work provides a promising strategy to design stable MOFs by improving the self-penetrating features and to expand their practical applications in the detection of organic pollutants in aqueous medium. 相似文献
48.
Jia Yang Xingang Li Wenjun Li Xin Xi Qian Du Feng Pan Songqing Liu 《Biomedical chromatography : BMC》2020,34(8):e4857
Because of its unpredictable side effects and efficacy, the anticancer drug docetaxel (DTX) requires improved characterisation of its pharmacokinetic profiles through population pharmacokinetic studies. A sensitive and rugged LC–MS/MS method for the detection of DTX in human plasma was developed and optimised using paclitaxel as an internal standard (IS). The plasma samples underwent rapid extraction using hybrid solid-phase extraction-protein precipitation. The analyte and IS were separated with an isocratic system on a Zorbax Eclipse Plus C18 column using water containing 0.05% acetic acid along with 20 μM of sodium acetate and methanol (30/70, v/v) as the mobile phase. Quantification was performed using a triple quadrupole mass spectrometer through multiple reaction monitoring in positive mode, using the m/z 830.3 → 548.8 and m/z 876.3 → 307.7 transitions for DTX and paclitaxel, respectively. The range of the calibration curve was 1–500 ng/mL for DTX, and the linear correlation coefficient was >0.99. The accuracies ranged from −4.6 to 4.2%, and the precision was no higher than 7.0% for the analytes. No significant matrix effect was observed. Both DTX and the IS showed considerable recovery. This method was finally applied to the establishment of a population pharmacokinetic model to optimise the clinical use of DTX. 相似文献
49.
50.