Electrochemiluminescence of Dendritic Magnetic Quantum Dots Nanostructure and Its Quenching by Gold Nanoparticles for Cancer Cells Assay

A novel dendritic CdS‐ZnS‐Quantum Dots (QDs) nanocomposite with intense electrochemiluminescence (ECL) and excellent magnetism was prepared, which was applied to the cancer cells assay based on ECL quenching of QDs by gold nanoparticles (NPs). DNA conjugation, gold NPs linking and sensing target cells can be directly performed on the magnetic nanocomposites, which is more rapid, convenient, and has better reproducibility than the conventional methods. So far, this is the first report on magnetic electrochemiluminescent QDs nanocomposites for cell detection based on ECL quenching, which opens a new approach for developing multifunctional QDs nanocomposite for ECL assays of cancer cells.     

Highly enantioselective intermolecular carbene insertion to C-H and Si-H bonds catalyzed by a chiral iridium(III) complex of a D4-symmetric Halterman porphyrin ligand

The chiral iridium porphyrin [Ir((-)-D(4)-Por*)(Me)(EtOH)] displays excellent reactivity and stereoselectivity towards carbene insertion to C-H and Si-H bonds, affording corresponding products in high yields (up to 96%) and high enantioselectivities (up to 98% ee).     

A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells

The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.     

Phase shift monitoring of delay-line interferometer and its application in phase-shift keying signal system

The relation between the phase shift and the mean optical power(MOP) output from a delay-line interferometer (DLI) port applied for phase-shift keying(PSK) signal demodulation is proven of a cosine law irrelevant to signal modulation condition.The variation amplitude of the MOP is proportional to the transition duration of the modulation pulses.This phenomenon is interpreted as the result of the statistical and waveform characteristics of the PSK.The conclusions verified by simulation and experiment are generalized to other modulation formats and then applied to phase detuning monitoring,delay time judgment of DLI,and independence of modulation data assessment.     

Syntheses, Characterization and Crystal Structures of Two Isostructural Hydrazone Compounds N′-(3-Bromo-5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide Methanol Solvate and N′-(3,5-Dichloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide Methanol Solvate

Abstract  

Reactions of 4-chlorobenzohydrazide with 3-bromo-5-chloro-2-hydroxybenzaldehyde and 3,5-dichloro-2-hydroxybenzaldehyde, respectively, afforded two isostructural hydrazone compounds, C₁₄H₉BrCl₂N₂O₂·CH₃OH (1) and C₁₄H₉Cl₃N₂O₂·CH₃OH (2). Both compounds were structurally characterized by X-ray determination. Compound 1 crystallizes in the triclinic space group P − 1 with unit cell dimensions a = 7.462(1) ?, b = 9.281(2) ?, c = 12.626(1) ?, α = 98.451(2)°, β = 98.630(2)°, γ = 100.025(2)°, V = 837.8(2) ?³, Z = 2, R ₁ = 0.0394 and wR ₂ = 0.0967. Compound 2 crystallizes in the monoclinic space group P2₁/n with unit cell dimensions a = 7.485(1) ?, b = 13.389(2) ?, c = 16.693(2) ?, β = 99.754(2)°, V = 1648.7(4) ?³, Z = 4, R ₁ = 0.0375 and wR ₂ = 0.0900. X-ray structural determination revealed that each compound consists of a hydrazone molecule and a methanol molecule of crystallization. In the crystal structures of both compounds, the adjacent molecules are linked by methanol molecules through N–H···O and O–H···O hydrogen bonds, forming dimers.     

Effects of high-order correlations on personalized recommendations for bipartite networks

In this paper, we introduce a modified collaborative filtering (MCF) algorithm, which has remarkably higher accuracy than the standard collaborative filtering. In the MCF, instead of the cosine similarity index, the user-user correlations are obtained by a diffusion process. Furthermore, by considering the second-order correlations, we design an effective algorithm that depresses the influence of mainstream preferences. Simulation results show that the algorithmic accuracy, measured by the average ranking score, is further improved by 20.45% and 33.25% in the optimal cases of MovieLens and Netflix data. More importantly, the optimal value depends approximately monotonously on the sparsity of the training set. Given a real system, we could estimate the optimal parameter according to the data sparsity, which makes this algorithm easy to be applied. In addition, two significant criteria of algorithmic performance, diversity and popularity, are also taken into account. Numerical results show that as the sparsity increases, the algorithm considering the second-order correlation can outperform the MCF simultaneously in all three criteria.     

分子电性作用矢量法用于硝基苯类化合物的毒性研究

基于定量结构-活性相关(QSAR)研究硝基苯类化合物的性质具有重要意义。采用分子电性作用失量(MEIV)表征硝基苯类有机毒物的分子结构,运用多元线性回归建立定量结构毒性相关(QSTR)模型,同时采用逐步回归结合统计检测筛选模型变量,建立了25个硝基苯类化合物对斜生栅藻(Scenedesmus obliquus)的急性毒性与其结构间的回归方程。另外采用内部及外部双重验证的办法深入分析和检验模型的稳定性。建模的复相关系数(Rcum2)、留一法(LOO)交互校验复相关系数(RCV2)和外部样本校验复相关系数(Qext2)分别为0.927、0.872和0.908。表明用MEIV表征硝基苯类有机物分子结构信息较好,所建QSTR模型的稳定性和预测能力良好。     

Vertical inventories and fluxes of <Superscript>210</Superscript>Pb, <Superscript>228</Superscript>Ra and <Superscript>226</Superscript>Ra at southern South China Sea and Malacca Straits

Inventories and fluxes of ²¹⁰Pb, ²²⁸Ra and ²²⁶Ra were determined in sediment cores collected at nine stations covering of the southern South China Sea and Malacca Straits with the thickness of water column between 42 and 83 m depth. The inventories of ²¹⁰Pb, ²²⁸Ra and ²²⁶Ra were calculated range from 0.15–2.55 Bq cm⁻², 0.05–0.40 Bq cm⁻² and 6.83–83.63 Bq cm⁻², meanwhile the fluxes ranged from 0.005–0.079 Bq cm⁻² yr⁻¹, 0.009–0.048 Bq cm⁻² yr⁻¹ and 0.003–0.037 Bq cm⁻² yr⁻¹, respectively. The results show that the highest inventories and fluxes for ²¹⁰Pb, ²²⁸Ra and ²²⁶Ra were found at station WC 01 and EC 05. Because there are additional sources of ²¹⁰Pb, ²²⁸Ra and ²²⁶Ra, where water transport will brings more dissolved isotopes, influence of the transportation and deposition of suspended particles, fast rate of regeneration and greater production of those radionuclides and others.     

A new strategy for lipid production by mix cultivation of Spirulina platensis and Rhodotorula glutinis

Mix cultivation of microalgae (Spirulina platensis) and yeast (Rhodotorula glutinis) for lipid production was studied. Mixing cultivation of the two microorganisms significantly increased the accumulation of total biomass and total lipid yield. Dissolved oxygen and medium components in the mixed fermentation medium were analyzed. Mix cultivation in monosodium glutamate wastewater was further studied. Result indicated 1,600 mg/L of biomass was obtained and 73% of COD were removed.     

Solvent-influenced syntheses and crystal structures of two azido-bridged polynuclear copper(II) complexes derived from 2-[(3-methylaminopropylimino)methyl]phenol with urease inhibitory activities

An end-on azido-bridged dinuclear Cu(II) complex, [Cu₂L₂(μ_1,1–N₃)₂]·CH₃OH, and an end-on azido-bridged polynuclear Cu(II) complex, [CuL(μ_1,1–N₃)]_n, derived from the Schiff base 2-[(3-methylaminopropylimino)methyl]phenol (HL), were synthesized and characterized by physico-chemical and spectroscopic methods. The two complexes were synthesized and crystallized with different solvents, methanol for [Cu₂L₂(μ_1,1–N₃)₂]·CH₃OH and ethanol for [CuL(μ_1,1–N₃)]_n. The Cu atom in each complex is five-coordinate in a square pyramidal geometry with one O and two N atoms of L, and one N atom of an azide ligand defining the basal plane, and with one N atom of another azide ligand occupying the apical position. The urease inhibitory activities of both complexes were evaluated.