Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer

During precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.     

High-speed scanning fiber-optic heterodyne interferometer using a micro-electro-mechanical system mirror and an f-theta lens

This paper describes a novel fiber-coupled heterodyne interferometer using a micro-electro-mechanical system (MEMS) mirror and an f-theta lens. In this interferometer system, the cross-polarized laser beams operating at 2 μm with the frequency difference of 100 kHz are introduced by means of the two acousto-optic modulators (AOM). The sample with diameter of 300 mm is uniformly scanned by the 1 mm laser beam with the help of the combined optical scanning configuration, a MEMS mirror and an f-theta lens. The output intermediate signal from the two channels, reference channel and the measurement channel, are processed in the 12 bit analog-to-digital (A/D) process system. Details of our interferometer scheme are discussed.     

Fabrication and characterization of double-wall carbon nanotube absorber for passive mode-locked Nd:GdVO<Subscript>4</Subscript> laser

Using the vertical evaporation technique we fabricated saturable absorbers by transferring the double-wall carbon nanotubes (DWCNT) onto a hydrophilic quartz substrate. The fast recovery time and the saturation intensity of the absorber were measured to be 228 fs and 130 μJ/cm², respectively, at 1060 nm. The modulation depth of the absorber was about 3.7%. Passive mode-locked Nd:GdVO₄ laser was demonstrated. The continuous wave mode-locked pulses pulse duration is 5.6 ps and the largest average output power is 1.2 W at the pump power of 9.5 W. To the best of our knowledge, this is the first demonstration of high power continuous wave mode locking laser with DWCNT absorber.     

含有本征SiGe层的SiGe异质结双极晶体管集电结耗尽层宽度模型

本文分别建立了含有本征SiGe层的SiGe HBT(异质结双极晶体管)集电结耗尽层各区域的电势、电场分布模型,并在此基础上,建立了集电结耗尽层宽度和延迟时间模型,对该模型进行了模拟仿真,定量地分析了SiGe HBT物理、电学参数对集电结耗尽层宽度和延迟时间的影响,随着基区掺杂浓度和集电结反偏电压的提高,集电结耗尽层延迟时间也随之增大,而随着集电区掺杂浓度的提高和基区Ge组分增加,集电结耗尽层延迟时间随之减小. 关键词： SiGe HBT 集电结耗尽层 延迟时间     

A planar left-handed metamaterial based on electric resonators

A planar left-handed metamaterial(LHM) composed of electric resonator pairs is presented in this paper.Theoretical analysis,an equivalent circuit model and simulated results of a wedge sample show that this material exhibits a negative refraction pass-band around 9.6GHz under normal-incidence and is insensitive to a change in incidence angle.Furthermore,as the angle between the arm of the electric resonators and the strip connecting the arms increases,the frequency range of the pass-band shifts downwards.Consequently,this LHM guarantees a relatively stable torlerence of errors when it is practically fabricated.Moreover,it is a candidate for designing multi-band LHM through combining the resonator pairs with different angles.     

基于高介电常数基板和金属结构负折射材料的设计,仿真与验证

通过将单回路镜像对称开口金属环结构印制在高介电常数基板上,实现了一种金属含量比传统负折射材料更少,"双负"通带比全介质负折射材料更宽的负折射材料.分析了高介电常数基板产生负介电常数以及"双负"通带形成的机理,通过仿真实验分析了影响"双负"通带的因素.通过制作样品验证了这一机理实现"双负"的可行性,理论分析与实验结果都表明这种方法可实现较宽频段内的"双负"通带. 关键词： 负折射材料 负介电常数 负磁导率 介质谐振器原理     

γ辐照掺杂SiO2的ESR研究

分别掺有磷和硼的二氧化硅经γ辐照后产生多种顺磁性中心,ESR研究指出氧空穴O^-主要稳定在杂质离子附近.O₂^-自由基稳定在Si离子上.F心的研究认为氧缺位俘获电子存在一个动态平衡过程.     

Continuity of Effect Algebra Operations in the Interval Topology

We study the continuity of and of effect algebras in the interval topology, and present several examples of effect algebras with interesting properties.     

Direct experimental limit on neutron-mirror-neutron oscillations

In case a mirror world with a copy of our ordinary particle spectrum would exist, the neutron n and its degenerate partner, the mirror neutron n', could potentially mix and undergo nn' oscillations. The interaction of an ordinary magnetic field with the ordinary neutron would lift the degeneracy between the mirror partners, diminish the n' amplitude in the n wave function and, thus, suppress its observability. We report an experimental comparison of ultracold neutron storage in a trap with and without superimposed magnetic field. No influence of the magnetic field is found and, assuming negligible mirror magnetic fields, a limit on the oscillation time taunn' > 103 s (95% C.L.) is derived.     

磷酸苯基二乙基酯的合成及波谱检测

作为有机磷小分子化合物 ,磷酰胺及其酯类衍生物大多具有广泛的生物活性。磷作为生命的重要元素 ,在生命体系中处于一种重要的地位 ,研究磷参与的生命过程的化学本质 ,对于更好地认识生命体及人类自身都具有重要意义。从化学意义上讲 ,磷参与的绝大部分生命过程 ,其化学本质都是磷酰基转移反应 ,对于这样一类生物体普遍存在的磷酰基转移反应 ,亦可应用到医药和农药上 ,对一些官能团进行结构改造 ,以改变其活性及仿生作用。Atherton Todd反应是合成此类物质极有价值的方法。为了进一步改善和提高水杨酸类药物的仿生作用 ,作者曾采用Atherton Todd反应合成了水杨酸羟基磷酸酯 ,但产率偏低。因此怀疑是水杨酸中羧基和羟基与磷酰化试剂发生竞争反应时羧基更具反应活性 ,为进一步探讨原因 ,文章选择了不含羧基的酯化过的水杨酸乙酯作为磷酰化反应的对象。结果首次采用改造后的Atherton Todd反应成功地制备出o [邻乙氧甲酰 (基 )苯基 ]磷酸二乙酯 ,并具较高产率。文章进一步详细给出了o [邻乙氧甲酰 (基 )苯基 ]磷酸二乙酯NMR谱数据 ,首次探讨了其ESI MS质谱裂解规律 ,对进一步合成更广泛的具有生物活性的酚类磷酸酯化合物将起到重要参考作用