89.
AbstractSixteen novel 3-methylthio-5-substituted benzamido-6-arylamino-1-phenyl-1
H-pyrazolo[3,4-
d]pyrimidin-4 (5
H)-one derivatives (
4a–p) were successfully synthesized from iminophosphoranes, aryl isocyanate, and substituted benzoylhydrazine. The structures of the title compounds were elucidated by FT-IR,
1H NMR,
13C NMR, and HRMS. Herbicidal activity of the compounds
4a–p against
Brassica napus (rape),
Echinochloa crusgalli (barnyard grass),
Cucumis sativus (cucumber), and
Triticum aestivum (wheat) were determined. The results showed that 5-(2-chlorobenzamido)-6-phenylamino-3-methylthio-1-phenyl-1
H-pyrazolo[3,4-
d]pyrimidin-4 (5
H)-one (
4c) displayed remarkable inhibition activity against the stalk and root of rape with 100% inhibition rate at the dosages of 10?mg/L and 100?mg/L, and 5-(4-nitrobenzamido)-6-phenylamino-3-methylthio-1-phenyl-1
H-pyrazolo[3,4-
d]pyrimidin-4 (5
H) -one (
4d) exhibited excellent activity against the stalk and root of barnyard grass with 100% inhibition rate at the same dosages.
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