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131.
Shangwen Luo Hahk-Soo Kang Aleksej Krunic George E. Chlipala Geping Cai Wei-Lun Chen Scott G. Franzblau Steven M. Swanson Jimmy Orjala 《Tetrahedron letters》2014
Two new (1 and 2) and three known (3–5) carbamidocyclophanes were isolated from a cultured freshwater cyanobacterium Nostoc sp. (UIC 10274) obtained from a sample collected at Des Plaines, Illinois. Their planar structures and stereoconfigurations were determined by extensive spectroscopic analysis including 1D/2D NMR experiments, HRESIMS as well as CD spectroscopy. Carbamidocyclophane F (1) showed potent anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 0.8 and 5.4 μM, respectively. Carbamidocyclophane F (1) also displayed antimicrobial activities against the gram positive bacteria Staphylococcus aureus and Enterococcus faecalis with MIC values of 0.1 and 0.2 μM, respectively. Carbamidocyclophane F (1) and Carbamidocyclophane G (2) both showed antiproliferative activity against MDA-MB-435 and HT-29 human cancer cell lines with IC50 values in the range from 0.5 to 0.7 μM. 相似文献
132.
Initiation of detonation by conical projectiles 总被引:2,自引:0,他引:2
Initiation of detonation by a hypersonic conical projectile launched into a combustible gas mixture is investigated. From analytic considerations of the flowfield, energetic and kinetic limits are proposed to predict the conditions required to initiate an oblique detonation wave in the mixture. To experimentally investigate these limits, projectiles with cone half angles varying from 15° to 60° were launched into a stoichiometric mixture of hydrogen/oxygen with 70% argon dilution at initial pressure between 10 and 200 kPa. The projectiles were launched from a combustion-driven gas gun at velocities as great as 2.5 km/s (corresponding to 150% of the Chapman Jouguet velocity). Pictures of the flowfields generated by the projectiles were taken via schlieren photography. Five combustion regimes could be observed about the projectile ranging from a prompt and delayed oblique detonation wave formation, combustion instabilities, a wave splitting, and an inert shock wave. The two theoretical limits provide a means to interpret the observed flowfield regimes and are in satisfactory agreement with the experimental results. 相似文献
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Regiocontrol of allylic alkylation reactions involving hard nucleophiles remains a significant challenge and continues to be an active area of research. The lack of general methods in which α-alkylation is favored underscores the need for the development of new processes for achieving this type of selectivity. We report that Cu(I) catalyzes the allylic substitution of phosphorothioate esters with excellent α-regioselectivity, regardless of the nature of the Grignard reagent that is used. To the best of our knowledge, the Cu-catalyzed allylic alkylation of phosphorothioate esters has never been described. We have also developed a simple protocol for inducing high α selectivity starting from secondary allylic halides. This is accomplished by using sodium phosphorothioates as an additive. 相似文献
135.
Shanju Zhang Zhan LiuDavid G. Bucknall Lihong HeKunlun Hong Jimmy W. MaysMark G. Allen 《Applied Surface Science》2011,257(22):9673-9677
The thermo-responsive behavior of polymer films consisting of novel linear triblock copolymers of poly(n-butyl methacrylate)-poly(methyl methacrylate)-poly(2-fluoroethyl methacrylate) (PnBuMA-PMMA-P2FEMA) are reported using differential scanning calorimetry (DSC), atomic forcing microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and contacting angle (CA) measurements. The surface morphology, wettability and chemical structure of thin films of these triblock copolymers on silicon wafers as a function of temperature have been investigated. It has been shown that the wettability of the films is thermally switchable. Detailed structural analysis shows that thermo-responsive surface composition changes are produced. The underlying mechanism of the thermoresponsive behavior is discussed. 相似文献
136.
This research develops a novel microfluidic mixing in a simple manner: An electrode was installed between two primary electrodes that generate DC fields and induce electroosmotic flow (EOF). While EOF was introduced by DC fields from the two primary electrodes, the active mixing could be achieved if potential was supplied to the secondary anode. Normal EOF was recovered as soon as the supply of potential to the secondary anode was terminated. By periodically repeating the on/off phase of the driving potential to the secondary anode, oscillating and vortex swirling flow patterns occurred and vigorous and efficient mixing was obtained. 相似文献
137.
Jimmy E. Jakobsson Shuiyu Lu Sanjay Telu Victor W. Pike 《Angewandte Chemie (International ed. in English)》2020,59(18):7256-7260
Herein, the synthesis and use of [11C]carbonyl difluoride for labeling heterocycles with [11C]carbonyl groups in high molar activity is described. A very mild single‐pass gas‐phase conversion of [11C]carbon monoxide into [11C]carbonyl difluoride over silver(II) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broad range of cyclic substrates, for example, imidazolidin‐2‐ones, thiazolidin‐2‐ones, and oxazolidin‐2‐ones. Labeling reactions may utilize close‐to‐stoichiometric precursor quantities and short reaction times at room temperature in a wide range of solvents while also showing high water tolerability. The overall radiosynthesis protocol is both simple and reproducible. The required apparatus can be constructed from widely available parts and is therefore well suited to be automated for PET radiotracer production. We foresee that this straightforward method will gain wide acceptance for PET radiotracer syntheses across the radiochemistry community. 相似文献
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The enantioselective synthesis of a dimeric pyranonaphthoquinone closely related to the cardinalins is described. Whilst attempts to effect a double Hauser-Kraus annulation of enone 5 were unsuccessful using both bis-phthalide 4 and bis-sulfone 21, a single annulation of cyanophthalide 28 with enone 5 furnished functionalised naphthalene 31. Suzuki-Miyaura homocoupling of the aryl triflate 29 derived from 31 effected a late-stage construction of the biaryl bond and facilitated access to the biaryl 3. Double stereoselective lactol reduction installed the 1,3-cis stereochemistry of the pyran rings and a final double oxidative demethylation step furnished model dimer 1, completing the enantioselective synthesis of a dimeric pyranonaphthoquinone bearing the core structure of cardinalin 3. 相似文献