Structural requirement of C11b chirality of tetrabenazine analogs as VMAT2 imaging ligands: synthesis and in vivo evaluation

We studied on the structural requirement of C11b chirality of tetrabenazine (TBZ) analogs as vesicular monoamine transporter 2 (VMAT2) ligands. TBZ analogs (2, 6a, 6b) and ¹⁸F-radiolabeled [¹⁸F]6a and [¹⁸F]6b with eliminated C11b chirality were synthesized and characterized. Competition studies demonstrated that 2, 6a and 6b displayed much lower in vivo VMAT2 bindings than TBZ. MicroPET imaging studies of [¹⁸F]6a and [¹⁸F]6b showed negligible accumulation in VMAT2-enriched regions as compared with the known VMAT2 ligand ¹⁸F-FP-(+)-DTBZ. These results suggest that C11b chirality of TBZ analogs is essential for in vivo VMAT2 binding bioactivity.     

Applicability of anthracite filtration‒micro electrolysis‒sand filtration for the treatment of surface waters containing high turbidity

The effect of combined filtration efficiency on the performance of anthracite filtration?micro electrolysis?sand filtration (AMS) was investigated. Impact of different operating parameters, such as iron?carbon ratio of micro electrolytic units, filtration velocity of AMS, were studied. It was found that when iron?carbon ratio was 6: 4, the AMS’s average turbidity removal rate was 96.75% at the filtration velocity of 3 m h^?1. The results showed that when the filtration rate was 3?9 m h^?1 and iron?carbon ratio was 6: 4, the turbidity removal efficiency was over 94%, and the turbidity of the effluent was less than 1 NTU in effective filtration cycle. The effective filtration cycle can last for more than 5 h or longer. Meanwhile, the removal rate of UV₂₅₄ was above 33%, and the concentration of iron ions in the effluent is less than 0.15 mg L^?1. Turbidity and iron indicators have reached the national drinking water standards. It was also found the mechanism of iron?carbon micro electrolytic enhanced filtration by infrared spectroscopy and scanning electron microscopy. And It was also speculated the reasons for the reaction passivation.     

Template synthesis of imine-based covalent organic framework core-shell structure and hollow sphere: a case of COF<Subscript>TTA-DHTA</Subscript>

Controllably synthesizing well-dispersed covalent organic frameworks (COFs) with uniform both morphology and size is still a challenge. Herein, we report the template-directed synthesis of COF_TTA-DHTA-based core-shell hybrids under solvothermal conditions by using amino-functionalized SiO₂ microspheres as templates coupled with stepwise addition of initial monomer molecules. The modified amino groups on the surfaces of SiO₂ templates play an important role in the formation of well-defined NH₂-f-SiO₂@COF_TTA-DHTA core-shell hybrids. COF_TTA-DHTA hollow spheres can be obtained by etching SiO₂ cores of NH₂-f-SiO₂@COF_TTA-DHTA. Both the NH₂-f-SiO₂@COF_TTA-DHTA and COF_TTA-DHTA hollow spheres possess the well-defined morphology, high crystallinity and porosity, excellent dispersion property and high chemical stability. The template synthesis method demonstrated in this work provides a general method for the shape-controlled synthesis of COF-based materials, which is important for the further applications in the fields such as energy storage, drug delivery and catalysis.     

Synergic Enhancement of High-density Polyethylene through Ultrahigh Molecular Weight Polyethylene and Multi-flow Vibration Injection Molding: A Facile Fabrication with Potential Industrial Prospects

General-purpose plastics with high strength and toughness have been in great demand for structural engineering applications. To achieve the reinforcement and broaden the application scope of high-density polyethylene(HDPE), multi-flow vibration injection molding(MFVIM) and ultrahigh molecular weight polyethylene(UHMWPE) are synergistically employed in this work. Herein, the MFVIM has better shear layer control ability and higher fabrication advantage for complex parts than other analogous novel injection molding technologies reported.The reinforcing effect of various filling times and UHMWPE contents as well as the corresponding microstructure evolution are investigated.When 5 wt% UHMWPE is added, MFVIM process with six flow times thickens the shear layer to the whole thickness. The tensile strength and modulus increase to 2.14 and 1.39 times, respectively, compared to neat HDPE on the premise of remaining 70% impact strength. Structural characterizations indicate that the enhancement is attributed to the improvement of shish-kebab content and lamellae compactness, as well as related to the corresponding size distributions of undissolved UHMWPE particles. This novel injection molding technology with great industrial prospects provides a facile and effective strategy to broaden the engineering applications of HDPE materials. Besides, excessive UHMWPE may impair the synergistic enhancement effect, which is also reasonably explained.     

The cantilever strip plate under torision, bending or flexure at infinity

A homogeneous, isotropic plate occupies the region 0x ₁, |x ₂|a, |x ₃|h, where the ratio h/a is sufficiently small so that the classical theory of thin plate bending applies. The short end of the plate at x ₁=0 is clamped while the long sides are free. This cantilever plate is now loaded at x ₁=+ by an applied twisting moment, by a bending moment or by flexure. Despite the fundamental nature of these problems, and the long history of thin plate theory, no solutions are to be found in the existing literature that will determine (for instance) the important unknown resultants V ₁, M ₁₁ at the clamped end x ₁=0. The main reason for this is that this combination of boundary conditions leads to severe oscillating singularities of the field in the corners (0, ±a). The fact that such singularities must exist is widely known, but we present here for the first time a method of solution that takes these singularities fully into account.Our numerical results show that the values of M ₁₁, V ₁ on x ₁=0 bear little resemblance to those of the corresponding Saint-Venant solutions, which do not fully satisfy the boundary conditions at the clamped end. Indeed, significantly large values of these resultants were found at points far enough from the corners so as to be relevant in actual engineering applications. Also of interest are certain weighted integrals of M ₁₁, V ₁ which we calculate. These constants determine the effect of the clamping at large distances (greater than 4a, say) from the cla,ped end. At such distances, the effect of the clamping is merely to impose an additional rigid body deflection on the plate.Finally, we consider the plate of finite length. Provided that the aspect ratio is 2 or more, we give accurate approximate solutions for the torsion, bending or flexure of a finite plate clamped at both ends.     

Numerical solution of Navier–Stokes equations using multiquadric radial basis function networks

A numerical method based on radial basis function networks (RBFNs) for solving steady incompressible viscous flow problems (including Boussinesq materials) is presented in this paper. The method uses a ‘universal approximator’ based on neural network methodology to represent the solutions. The method is easy to implement and does not require any kind of ‘finite element‐type’ discretization of the domain and its boundary. Instead, two sets of random points distributed throughout the domain and on the boundary are required. The first set defines the centres of the RBFNs and the second defines the collocation points. The two sets of points can be different; however, experience shows that if the two sets are the same better results are obtained. In this work the two sets are identical and hence commonly referred to as the set of centres. Planar Poiseuille, driven cavity and natural convection flows are simulated to verify the method. The numerical solutions obtained using only relatively low densities of centres are in good agreement with analytical and benchmark solutions available in the literature. With uniformly distributed centres, the method achieves Reynolds number Re = 100 000 for the Poiseuille flow (assuming that laminar flow can be maintained) using the density of , Re = 400 for the driven cavity flow with a density of and Rayleigh number Ra = 1 000 000 for the natural convection flow with a density of . Copyright © 2001 John Wiley & Sons, Ltd.     

An experimental study of diabatic spiral vortex flow

In spiral vortex flow, between concentric cylinders with the inner cylinder rotating and the outer stationary, the addition of a thermal gradient across the gap is a known complicating factor. The present diabatic study for narrow and wide gaps (radius ratios N=0.955 and N=0.8), with a heated outer and adiabatic inner cylinder, was undertaken to investigate this problem. The heat transfer characteristics and the modes of transition have been investigated together with the relationship between them. Using standard on-line digital computer techniques, the onset of vortex flow and its higher transitions have been shown to cause a sharp increase in Nusselt number. At higher Taylor numbers, of the order of 10⁶, a marked change in the Nusselt number occurs with the onset of the transition to periodic turbulent vortex flow. Outer wall heating is seen to affect the modes of transition. Diabatic critical Taylor numbers are much higher than those for adiabatic conditions and are found to depend on the close approach of the vortices to the outer wall     

Semiclassical Limit of the Gross-Pitaevskii Equation in an Exterior Domain

In this paper, we study the semiclassical limit of the Gross-Pitaevskii equation (a cubic nonlinear Schrödinger equation) with the Neumann boundary condition in an exterior domain. We prove that before the formation of singularities in the limit system, the quantum density and the quantum momentum converge to the unique solution of the compressible Euler equation with the slip boundary condition as the scaling parameter approaches 0.