Racemic Norlignans as Diastereoisomers from Ferula sinkiangensis Resins with Antitumor and Wound-Healing Promotion Activities

Ferulasinkins A–D (1–4), four new norlignans, were isolated from the resins of Ferula sinkiangensis, a medicinal plant of the Apiaceae family. All of them were obtained as racemic mixtures, chiral HPLC was used to produce their (+)- and (−)-antipodes. The structures of these new compounds, including their absolute configurations, were elucidated by spectroscopic and computational methods. This isolation provides new insight into the chemical profiling of F. sinkiangensis resins beyond the well-investigated structure types such as sesquiterpene coumarins and disulfides. Compounds 2a and 3a were found to significantly inhibit the invasion and migration of triple-negative breast cancer (TNBC) cell lines via CCK-8 assay. On the other hand, the wound-healing assay also demonstrated that compounds 4a and 4b could promote the proliferation of human umbilical vein endothelial cells (HUVECs). Notably, the promoting effects of 4a and 4b were observed as more significant versus a positive control using basic fibroblast growth factor (bFGF).     

基于CSIFT的彩色图像配准技术研究

图像配准在计算机视觉、遥感、医学诊断与治疗、环境监测等领域有广泛的研究应用.目前,多数算法是将彩色图像转化为灰度图后再配准,色彩信息的丢失可能会引起误配准.为此,提出一种基于CSIFT(Colored scale invariant feature transform)的彩色图像配准方法,求出彩色图像各个位置处的颜色不变最,以颜色不变量作为输入图像,再提取特征点并描述特征点周围的信息,通过最近邻匹配法求出图像问的匹配对,最后利用匹配的特征求取图像间的变换参数及配准后图像.实验结果表明,对彩色图像进行已知参数值变换时,该算法能得到精度高、误差小的计算结果;对变换关系末知的彩色图像,也能准确地求出图像间的映射关系;且多数情况下运行速度较SIFT(Scale invariant feature transform)快.     

BF3-promoted annulation of azonaphthalenes and ynamides for synthesis of benzo[e]indoles

A novel BF₃-promoted [3+2] annulation of azonaphthalenes and ynamides is described.This protocol provides a modular and efficient entry to functionalized amino benzo[e]indole derivatives smoothly.     

Experiment and simulation of environmental chamber performance for fuel cell vehicle engine system

Journal of Thermal Analysis and Calorimetry - Comprehensive performance experiments were carried out, and the thermodynamic temperature simulation model was established based on the independently...     

Electrochemical Tri- and Difluoromethylation-Triggered Cyclization Accompanied by the Oxidative Cleavage of Indole Derivatives

Considering their unique roles in organic synthesis, and pharmaceutical and agrochemical applications, the development of fluoroalkylation, cyclization, and indole oxidative cleavage are important topics. Herein, an unprecedented electrochemical tri- and difluoromethylation/cyclization/indole oxidative cleavage process occurring in an undivided cell is presented. The protocol employs a readily prepared Langlois reagent as the fluoroalkyl source, affording a series of tri- or difluoromethylated 2-(2-acetylphenyl)isoquinoline-1,3-diones in good yields with excellent stereoselectivity. It is worth noting that this new methodology merges the fluoroalkylation/cyclization of N-substituted acrylamide alkenes with the oxidative cleavage of an indole C(2)=C(3) bond under external oxidant-free conditions.     

Double-Network Heparin Dynamic Hydrogels: Dynagels as Anti-bacterial 3D Cell Culture Scaffolds

Double cross-linked dynamic hydrogels, dynagels, have been prepared through reversible imine bonds and supramolecular interactions, which showed good pH responsiveness, injectability, self-healing property and biocompatibility. With the further encapsulation of heparin, the obtained hydrogels exhibited good anti-bacterial activity and promotion effects for 3D cell culture.     

Mechanically strong and stiff supramolecular polymers enabled by fiber reinforced long-chain alkane matrix

Fiber-reinforced-concrete (FRC) mechanism refers short discrete fibers that are uniformly distributed and randomly oriented, which offers an effective way to improve the mechanical performance of concrete. In the design of supramolecular polymers, an analogous concept of FRC appears to have been considered very rarely-although fibrous structure has been frequently observed/generated during the supramolecular polymerization. In this work, we apply the alkane thermosets, octadecane (C₁₈H₃₈) and tetracosane (C₂₄H₅₀), taking the role of “concrete”, and the low-molecular-weight monomer with long alkyl chains as the essential “fiber” component, to fabricate the “fiber reinforced supramolecular polymer”. Very much like FRC mechanism in material science, the resulting fiber reinforced supramolecular polymer thus exhibit unusually high mechanical strength and stiffness, which is unprecedented in the conventional supramolecular strategy.     

Synthesis and characterization of three co-crystals of bis(benzimidazole) derivatives with aromatic dicarboxylic acids

Research on Chemical Intermediates - Combination of three aromatic carboxylic acids (5-nitroisophthalic acid (H2nip), 2,6-naphthalenedicarboxylic acid (H2ndc), tetrabromoterephthalic acid (H2tbta))...     

A High-Efficiency Hematite Photoanode with Enhanced Bonding Energy Around Fe Atoms

Hematite nanoarrays are important photoanode materials. However, they suffer from serious problems of charge transfer and surface states; in particular, the surface states hinder the increase in photocurrent. A previous strategy to suppress the surface state is the deposition of an Fe-free metal oxide overlayer. Herein, from the viewpoint of atomic bonding energy, it is found that the strength of bonding around Fe atoms in the hematite is the key to suppressing the surface states. By treating the surface of hematite with Se and NaBH₄, the Fe₂O₃ transforms to a double-layer nanostructure. In the outer layer, the Fe−O bonding is reinforced and the Fe−Se bonding is even stronger. Therefore, the surface states are inhibited and the increase in the photocurrent density becomes much faster. Besides, the treatment constructs a nanoscale p–n junction to promote the charge transfer. Improvements are achieved in onset potential (0.25 V shift) and in photocurrent density (5.8 times). This work pinpoints the key to suppressing the surface states and preparing a high-efficiency hematite nanoarray, and deepens our understanding of hematite photoanodes.     

温度对NH3气体紫外吸收截面影响研究

为了研究NH3气体在紫外203～220 nm内吸收截面随温度的变化规律,采用高分辨率光栅单色仪、氘灯光源、闭式气样室和配气装置,测量NH3气体温度由308 K升高至397 K的吸收截面.NH3气体吸收截面由离散吸收和连续吸收两部分组成.结果表明,随着温度的升高,基态剩余量子旋转、振动迁移到激发态的概率减少,最终导致离散吸收截面峰值的降低.随着温度由308 K升高至397 K,在特征波长212.5 nm处,离散吸收截面峰值的最大相对减幅为46%.NH3气体在这个波段的吸收截面存在明显的等波长间隔分布特征,约为4 nm.随着温度升高,峰值位置未见变化.连续吸收截面整体上随温度升高而减小,且这种减小趋势随波长红移逐渐减弱.由于NH3气体吸收截面随温度的变化呈现较大的变化,实测时应对气体浓度在线测量结果进行温度补偿计算.