Amino‐Containing Ultrafine Organosilica‐Nanoparticle‐Modified Au Electrode for the Determination of Cu(II) Ions

Using 3‐Aminopropyltriethoxysilane(APTES) as a single silica source, an amino‐rich ultrafine organosilica‐nanoparticle‐modified Au electrode was fabricated, following the formation of (3‐mercaptopropyl)‐trimethoxysilane (MPTS) monolayer on Au surface (MPTS/Au). With cetyltrimethylammonium bromide as an additive, APTES‐based gel particles on the electrode have a narrow particle size distribution of 4–7 nm and “crystal‐like” structure. AFM and electrochemical characterization confirmed the successful grafting of APTES nanoparticles on MPTS/Au. The APTES/MPTS/Au electrode is highly sensitive for the detection of copper(II) ions with a detection limit as low as 1.6×10^?12 mol L^?1 (S/N>3) by square wave voltammetry. The current is linear to copper(II) concentration between 1.6×10^?12 and 6.25×10^?10 mol L^?1.     

Synthesis and Properties of a Sulfonic Acid-Containing Gemini Surfactant

A novel sulfonic acid-containing gemini surfactant, 6,6′-(butane-1,4-diylbis(oxy)) bis(3-nonylbenzenesulfonic acid), 9BA-4-9BA, was synthesized in high purity and high yield using a facile preparation pathway, and characterized by FTIR, ¹H NMR, and elemental analysis. The content of two sulfonic acid groups was measured by the acid-base titration. DSC and TGA were used to reveal the thermal properties and the product purity. The surface properties of 9BA-4-9BA were evaluated by equilibrium surface tension measurement. It shows that its CMC was 0.65 mmol/L, while the C₂₀ of 0.018 mmol/L was above two orders of magnitude lower than that of traditional monomeric surfactants such as SDS and SDBS, indicating excellent efficiency of micelle formation and reduced surface tension.     

考虑混凝土应变率变化的高拱坝非线性动力响应研究

提出一种新的应变率相关的混凝土非线性弹塑性损伤模型。采用此模型对混凝土拱坝的非线性地震响应作了分析。在综合考虑坝-地基-库水动力相互作用和坝缝非线性接触的基础上，着重研究了混凝土应交率相关效应及加载历史对混凝土极限强度等重要参数及拱坝响应的影响，并与采用不考虑应交率影响的混凝土损伤模型计算结果进行了对比分析。结果表明，拱坝考虑横缝作用后的坝面应变率分布不同于整体拱坝。应交率分布形态不仅可以很好地表征拱坝的振动形态，而且对于高拱坝的动力响应的影响也不可忽略。     

拟协调等腰梯形壳元显式几何刚度阵及屈曲分析

采用拟协调元方法推导了等腰梯形薄壳元的显式几何刚度阵，用于组合结构屈曲分析的计算，结果表明，这种单元的几何刚度阵收敛快、精度好。     

苯基磷酸单烷基脂稀土萃取剂的理论研究(英文)

用分子动力学方法和半经验量子化学方法研究了九个苯基磷酸单烷基脂稀土萃取剂的几何结构和电子结构．每个萃取剂的几何构型构通过PM3方法优化得到．结果表明，烷氧基上取代基的空间位阻效应比主链大．计算得到的羟基氧原子的电荷与萃取剂的酸解离常数pKa呈线性关系．     

核磁共振仪受环境随机激励的非线性隔离与参数优化

本文针对核磁共振仪的隔离问题,提取非线性随机振动理论模型,在FPK方程中对系统的参数进行了优化,用统计线性化方法计算响应;用非线性隔离系统传递率的定义计算隔振效果,最后对隔离装置进行了实验分析和信号处理,并对理论计算与实验结果进行了对比.     

一种结构参数识别的两阶段方法

针对测量信息不完备的剪切型结构 ,建立了一种两阶段系统识别的复合反演方法 ,这种方法包括两部分 :子结构地震动反演和结构参数识别。首先 ,选取可观测的子结构 ,利用一维地震动作用于结构的力学特性 ,将子结构动力方程的有限元列式进行变换 ,得到适合于最小二乘法的简单形式 ,解决了测量信息不完备及结构参数未知条件下的地震动反演问题。其次 ,根据子结构反演得到的地震动输入 ,采用结构参数时域识别技术中的加权整体迭代 -广义卡尔曼滤波器方法 ,成功地识别出了有限测量条件下单元水平结构参数     

The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand‐binding domain

The effect of retinoid X receptor (RXR) antagonists on the conformational exchange of the RXR ligand‐binding domain (LBD) remains poorly characterized. To address this question, we used nuclear magnetic resonance spectroscopy to compare the chemical shift perturbations induced by RXR antagonists and agonists on the RXRα LBD when partnered with itself as a homodimer and as the heterodimeric partner with the peroxisome proliferator‐activated receptor γ (PPARγ) LBD. Chemical shift mapping on the crystal structure showed that agonist binding abolished a line‐broadening effect caused by a conformational exchange on backbone amide signals for residues in helix H3 and other regions of either the homo‐ or hetero‐dimer, whereas binding of antagonists with similar binding affinities failed to do so. A lineshape analysis of a glucocorticoid receptor‐interacting protein 1 NR box 2 coactivator peptide showed that the antagonists enhanced peptide binding to the RXRα LBD homodimer, but to a lesser extent than that enhanced by the agonists. This was further supported by a lineshape analysis of the RXR C‐terminal residue, threonine 462 (T462) in the homodimer but not in the heterodimer. Contrary to the agonists, the antagonists failed to abolish a line‐broadening effect caused by a conformational exchange on the T462 signal corresponding to the RXRα LBD–antagonist–peptide ternary complex. These results suggest that the antagonists lack the ability of the agonists to shift the equilibrium of multiple RXRα LBD conformations in favor of a compact state, and that a PPARγ LBD‐agonist complex can prevent the antagonist from enhancing the RXRα LBD‐coactivator binding interaction. Copyright © 2009 John Wiley & Sons, Ltd.     

Polyaniline doped with modified gold nanoparticles and its electrochemical properties in neutral aqueous solution

Doping polyaniline with COO(-)-modified gold nanoparticles by forming stable layer-by-layer multilayer films can shift its electroactivity to neutral pH. The films can electrocatalyze the oxidation of NADH and offer potential applications in other fields, e.g., optoelectronics or biosensing.     

Electrochemical detection coupled with high-performance liquid chromatography in pharmaceutical and biomedical analysis: a mini review

Recent advances in electrochemical detection techniques coupled with high-performance liquid chromatography (HPLC-ECD) in pharmaceutical and biomedical analysis are reviewed. ECD classification and modes including common amperometric, coulometric, conductimetric, and potentiometric detector, are outlined and the some typical examples of determinations in pharmaceutical and biomedical analysis are described. The electrochemical detection system can offer superior merits over other detectors commonly used with HPLC. These techniques have great potential owing to their prominent characteristics in high-throughput screening procedures of drugs in various matrices. Fundamental 67 references from last 5 years related with a field are cited in this review.