具有双向认证功能的量子秘密共享方案

利用两粒子纠缠态作为经典信息的载体,结合Hash函数和量子本地操作提出了一种可以实现双向认证功能的量子秘密共享方案,并且分析了它的安全性. 这种方案的安全性基于秘密共享双方的认证密钥和传输过程中粒子排列次序的保密. 若不考虑认证和窃听检测所消耗的粒子,平均1个Bell态共享2 bit经典信息. 关键词： 量子秘密共享 认证密钥 量子双向认证 两粒子量子纠缠     

3-氨基苯硼酸-苯胺共聚物薄膜对pH的光学响应

在硫酸介质中,以氧化铟锡(ITO)透明导电玻璃为基质材料,应用循环伏安法制备3-氨基苯硼酸-苯胺共聚物薄膜.用紫外可见光谱方法测定了共聚物薄膜在不同pH下的特征吸收光谱,结果表明,在pH 2-12范围内共聚物薄膜对pH的变化表现了极高的光学敏感性,当pH从2增加到12时,其λmsa从773nm(pH=2)变化到614nm(pH=12);由相应的滴定曲线计算共聚物薄膜的表观pKa为6.21薄膜对pH响应速度快,光谱变化在20s内基本完成;共聚物薄膜对pH响应的重现性较好,重复使用在最大吸收773nm处吸光度的变化为1.0%,在614nm处吸光度的变化为0.7%.     

Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa

Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG2 cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.     

温敏核不育系水稻株1S及其矮秆突变体SV14茎的蛋白质组学比较

采用双向凝胶电泳对温敏核不育水稻株1S和其矮秆突变体SV14的茎(穗颈下第1节和第2节)蛋白进行了分离, 通过银染显色, 获得了分辨率和重复性较好的双向电泳图谱. 选取了26个蛋白质点采用MALDI-TOF-MS进行肽质谱指纹图分析, 最终有12个蛋白质点得到了可靠鉴定. 其中在SV14中相对于株1S上调的仅有OSJNBa0039C07.13 蛋白, 其它蛋白均表现为下调. 这些差异蛋白按照功能可分为4类: (1) 能量代谢相关蛋白; (2) 次生代谢相关蛋白; (3) 调控蛋白; (4) 未知蛋白. 对光合系统Ⅱ氧延伸复合物蛋白质前体2, 果糖二磷酸醛缩酶, UDP-葡糖醛酸脱羧酶对应的基因进行了半定量RT-PCR分析, 发现这几个基因与蛋白质的表达不一致, 可能是RNA发生了翻译后修饰而减少了蛋白表达量的结果. 这些差异蛋白很可能与水稻矮化有关, 为水稻矮秆基因的寻找提供了另一个有效途径.     

Amino acid derivatives of pyropheophorbide-α ethers as photosensitizer: Synthesis and photodynamic activity

Ten new water-soluble amino acid conjugates of pyropheophorbide-α ethers 4a-4j were synthesized and investigated for their in vitro photodynamic antitumor activity. The results showed that all compounds exhibited higher phototoxicity and lower dark toxicity against three kinds of tumor cell lines than BPD-MA. In particular, themost phototoxic compound 4d and 4j individually showed IC₅₀ values of 41 nmol/L and 33 nmol/L against HCT116 cell, which represented 7.8- and 9.7-fold increase of antitumor potency compared to BPD-MA, respectively, suggesting that they were promising photosensitizers for PDT applications because of their strong absorption at long wavelength (λ_max>650 nm), high phototoxicity, low dark cytotoxicity and good water-solubility.     

界面移动法测定离子迁移数实验的优化

在基础物理化学实验界面移动法测定离子迁移数中,针对传统实验方案所用镉电极存在的不足之处,改用铜电极进行了平行对比实验,发现采用铜电极的实验方案在保证实验数据有良好准确度的前提下,既能降低电极材料的毒性,也能降低实验相关设备的配置要求。     

Copper- and ligand-free Sonogashira reaction catalyzed by palladium in microemulsion

An oil-in-water microemulsion containing PdCl2 and NaOH can be used as an effective catalyst system for rapid copper- and ligand-free Sonogashira reaction of aryl halides and phenylacetylene. Excellent yield of the Sonogashira reaction catalyzed by 0.5 mol% palladium could be achieved within 5 min. The types of base have an intense influence on the reaction. The reaction rate was increased with increased aqueous content in the microemulsions, and dispersed palladium nanoparticles can be in situ formed without other reductants.     

以聚丙烯酰胺凝胶为基质的光导纤维pH传感器

以凝胶为基质的新型固定化试剂制备了3种pH荧光传感器.在实验条件下,其信号响应时间低于10s,pH突跃范围为1.83～7.54和1.39～2.97.基本上无试剂脱落,在试剂本身化学稳定期限内,具有一定的使用寿命.     

石杉碱甲类拟物的合成及药理研究1: (±)-14-氟石杉碱甲

用两种方法合成了(±)-14-氟石杉碱甲(6), 并测定了其抑制乙酰胆碱酯酶的生物活性。其抑制活性是(-)-石杉碱甲(1)的1/62。