<Emphasis Type="Italic">ε</Emphasis>-Poly(L-lysine)-based Hydrogels with Fast-acting and Prolonged Antibacterial Activities

Bacterial infections and the associated morbidity and mortality due to bacterial pathogens in wounds and medical implants have been increasing as most of current coatings cannot fulfill all the requirements including excellent intrinsically antibacterial activity, low cytotoxicity, and favorable physical properties. Herein, we present a kind of antibacterial hydrogel based on ε-poly(L-lysine) (EPL) grafted carboxymethyl chitosan (CMC-g-EPL) as the inherently antibacterial matrix and the surplus EPL as highly efficient antimicrobial agent. Such hydrogels possess tunable swelling abilities with water absorption percentages of 800%-2000% and modulus varying from 10 kPa to 100 kPa, and exhibit two-stage excellent antibacterial behavior. First, the free EPL can be released from the hydrogel network for quick and highly efficient bacteria killing with 99.99% of efficacy; second, the grafted EPL endows hydrogel matrix with prolonged intrinsically antibacterial activity, especially when most of free EPL is released from the hydrogel. Overall, we provide a new insight for preparing highly effective antibacterial hydrogels.     

In situ formation of dispersed palladium nanoparticles in microemulsion: efficient reaction system for ligand-free Heck reaction

The ligand-free Heck reaction catalyzed by Pd(OAc)2 performed well in a TX10 oil-in-water microemulsion. TEM proved in situ formation distributed palladium nanoparticles in the microemulsion. The role of TX10 in the reaction system is the palladium nanoparticles reducing agent and stabilizer. The effect of reaction parameters on the Heck reaction conversion were discussed. The results indicated that the aqueous phase concentration, the base concentration, and the temperature played key roles in the conversion of the reaction. Iodobenzene was converted to the corresponding trans-stilbene quantitatively within 90-150 min. Therefore, the heptane/TX 10/butanol/water/propylene glycol microemulsion containing in situ formed palladium nanoparticles was a very efficient catalyst system for the ligand-free Heck reaction.     

液相色谱-电喷雾串联四极杆质谱法测定植物源性食品中氟草烟的残留量

1引言氟草烟(Fluroxypyr)的商品名称为使它隆(Starane),化学名称为4-氨基-3,5-二氯-6-氟吡啶-2-氧乙酸。氟草烟是一种内吸传导型苗后除草剂,对小麦、大麦、元麦、玉米田间及果园的多种杂草有良好的防除效果。近年来欧盟、美国和日本对部分谷物、蔬菜、水果等植物产品和动物源性     

Copper- and ligand-free Sonogashira reaction catalyzed by palladium in microemulsion: effects of surfactant and alcohol

A rapid copper- and ligand-free Sonogashira reaction was performed in an oil-in-water microemulsion. Palladium nanoparticles can be in situ formed in the microemulsion without other reductants. The microemulsion containing in situ-formed nano-Pd is an efficient system for the Sonogashira reaction. The reactions were faster in the microemulsion than in micelles. The effects of surfactant, alcohol, and temperature are discussed. Excellent yield of the Sonogashira reaction catalyzed by 0.5 mol% palladium could be achieved at 80 degrees C within 2 min.     

海洋环肽Phakellistatin 13的全合成研究

Phakellistatin 13是从海绵中分离得到的高活性的抗肿瘤环七肽化合物, 是优良的抗肿瘤先导化合物. 我们结合逐步接肽法和片段缩合法, 首次采用液相法完成Phakellistatin 13的全合成, 并提出与以往报道不同的多肽环合策略. 目标化合物经质谱与核磁共振光谱结构确证与天然产物一致, 为进一步开展Phakellistatin 13及其类似物的抗肿瘤活性研究打下了扎实的基础.     

普通铸造和低频电磁铸造7050铝合金电阻率-温度特性的研究

利用四端接线法测量以普通铸造(DC)和低频电磁铸造(LFEC)两种不同方法制备的7050铝合金的电阻率-温度曲线. 发现升温曲线在250℃有一斜率转变点,且LFEC样品电阻率随温度变化得要快;由室温至900℃的过程中,LFEC试样的液固相线温度均高于DC试样;而DC试样在900℃保温甚至降温至600℃电阻率都显著增大. 结合金相显微组织的观察,对上述现象进行理论分析. 关键词： 低频电磁铸造 电阻率 铝合金 洛伦兹力     

关于叶轮机时均(准四维)和非定常(四维)气动设计体系的初步诠释

本文以考虑非定常流动的完整性为线索,总结概述了先前气动设计体系的困难与限制,在此基础上,以描述叶轮机流动的时均和时间精确模型为核心分别从其构成和标志性技术对叶轮机时均和非定常气动设计体系进行了初步诠释。文章认为促成时均(准四维)和非定常(四维)气动设计体系现实应用是叶轮机发展的最后契机。     

The Application of Lie Algebra Method in Induced Heavy Nuclei Fission

The propagator method is efficient in solving the Fokker-Planck equation.with an inharmonic oscillator potential. The propagator is deri;ed by using the Lie algebra method. The fission rate of ²⁴⁰Pu is calculated based on the expression of the propagator. The numerical results show that the rate is reasonable.     

Fabrication of Magnetic Al-Based Fe3O4@MIL-53 Metal Organic Framework for Capture of Multi-Pollutants Residue in Milk Followed by HPLC-UV

The efficient capture of multi-pollutant residues in food is vital for food safety monitoring. In this study, in-situ-fabricated magnetic MIL-53(Al) metal organic frameworks (MOFs), with good magnetic responsiveness, were synthesized and applied for the magnetic solid-phase extraction (MSPE) of chloramphenicol, bisphenol A, estradiol, and diethylstilbestrol. Terephthalic acid (H₂BDC) organic ligands were pre-coupled on the surface of amino-Fe₃O₄ composites (H₂BDC@Fe₃O₄). Fe₃O₄@MIL-53(Al) MOF was fabricated by in-situ hydrothermal polymerization of H₂BDC, Al (NO₃)₃, and H₂BDC@Fe₃O₄. This approach highly increased the stability of the material. The magnetic Fe₃O₄@MIL-53(Al) MOF-based MSPE was combined with high-performance liquid chromatography-photo diode array detection, to establish a novel sensitive method for analyzing multi-pollutant residues in milk. This method showed good linear correlations, in the range of 0.05–5.00 μg/mL, with good reproducibility. The limit of detection was 0.004–0.108 μg/mL. The presented method was verified using a milk sample, spiked with four pollutants, which enabled high-throughput detection and the accuracies of 88.17–107.58% confirmed its applicability, in real sample analysis.