Direct Electrochemistry of Hemoglobin Immobilized in Sodium Alginate Film on the Ionic Liquid [BMIM]PF6 Modified Carbon Paste Electrode

In recent years the direct electron transfer of redox protein on electrode surface has attracted great attentions1. Different kind of modified electrode and various supporting films for immobilization of proteins had been proposed. But most of them are ba…     

The preparation of a new polysiloxane copolymer with glucosylthioureylene groups on the side chains

A new polysiloxane with pendent sugar units was prepared by a two-step method: the preparation of the polysiloxane with amino groups on the side chain and then the copolysiloxane reacted with glucosyl isothiocyanate. All polymers were characterized by FT-IR 1H-NMR, 1H-1H-COSY, 13C-NMR, and DEPT respectively. In the same time, Platinum oxide was found to be a versatile and powerful hydrosilation catalyst in the hydrosilylation reaction of aminotrimethylenepolysiloxanes with heptamethylcyclotetrasiloxane (D₄^H).     

Fabrication, Characterization and Electrocatalysis of an Ordered Carbon Nanotube Electrode

A method for fabrication of ordered carbon nanotube (CNT) film,which was template-synthesized within the highly ordered pores of a commercially available alumina template membrane,modified glassy carbon(CNT/GC) electrode was established.The CNT/GC electrode showed excellent electrocatalytic activity toward dopamine electrochemical reaction without introducing any electrochemically active group into CNT film or activating any electrochemically active group into CNT film or activating the electrode electrochemically.DA undergoes ideal reversible electrochemical reaction on CNT/GC electrode at low scan rate(≤20mV/s) with an excellent reproducibility and stability.The CNT/GC electrode might be used in biosensors because the highly ordered CNT may present a steric effect on more efficient redox reactions of biomolecules.     

(C(wedge)N(wedge)N)Pt(C identical to C)nR] (HC(wedge)N(wedge)N = 6-aryl-2,2'-bipyridine,n = 1-4, R = aryl,SiMe3) as a new class of light-emitting materials and their applications in electrophosphorescent devices

Tridentate cyclometalated platinum(II) complexes bearing sigma-alkynyl ligands exhibit tunable photoluminescence and enhanced stability during vacuum deposition; OLEDs based on these materials display orange to red electrophosphorescence with low turn-on voltages (approximately 4 V), maximum luminance approaching 10,000 cd m-2 and efficiency up to 4.2 cd A-1.     

Molecular structure of 1,2,4-triazole

The molecular structure of 1,2,4-triazole has been determined by gas phase electron diffraction. The intemuclear distances and bond angles were obtained by applying a least-squares analysis to the experimental intensity. The bond distances (r_g) and bond angles were N₁-N₂ = 1.380 ± 0.010 Å, N₂C₃ = 1.329 ± 0.009 Å, C₃-N₄ = 1.348 ± 0.009 Å, N₁-C₅ = 1.377 ± 0.004 Å, N₄C₅ = 1.305 Å (calculated value). N-H = 0.990 Å, C-H = 1.054 Å, ∠N₁N₂C₃ = 102.7± 0.5°, ∠N₂C₃N₄ = 113.8 ± 1.3°, ∠N₂N₁C₅ = 108.9 ± 0.8°, ∠H₁N₁N₂ = 110.9°, ∠H₂C₃N₄ = 119.2°, ∠H₃C₅N₁ = 131.0°, ∠C₃N₄C₅ = 105.7° (calculated value) and ∠N₄C₅N₁ = 108.7° (calculated value).     

超临界CO2中甲醇和乙醇无限稀释扩散系数的分子动力学模拟与实验测定

采用分子动力学模拟(MD)方法对甲醇和乙醇在超临界二氧化碳中的无限稀释扩散系数进行了模拟计算, 并应用泰勒分散理论, 采用超临界色谱仪对模拟结果进行了实验验证. 模拟计算值与实验值较吻合, 且变化规律基本一致, 表明采用这种新方法可以准确有效地预测超临界体系的扩散性质, 能够方便地应用于工程设计.     

Synthesis and characterization of three tetranuclear clusters containing a [Mo3OS3Sn]6+ cubane-like core

Three heterometallic cubane-like clusters, [Mo3(mu 3-O)(mu 3-S)3(SnCl3)(dtp)3(py)3] (dtp = S2P(OC2H5)2-, py = C5H5N) (1), (PPN)[Mo3(mu 3-O)(mu 3-S)3(SnCl3)(dtp)3(mu-OAc)(py)] (OAc = CH3COO-, PPN = (C6H5)3PNP(C6H5)3+) (2), and (Et4N)[Mo3(mu 3-O)(mu 3-S)3(SnCl3)(dtp)2(mu-OAc)2(py)] (3) have been prepared by the reaction of [Mo3(mu 3-O)-(mu-S)3(dtp)4(H2O)] (4), [Mo3(mu 3-O)(mu-S)3(dtp)3(OAc) (py)] (5), and [Mo3(mu 3-O)(mu-S)3(dtp)2(OAc)2 (py)] (6) with SnCl2, respectively. They have been characterized by IR, UV-vis, 31P NMR, 95Mo NMR, and X-ray structure analysis. All of these heterometallic clusters have a [Mo3OS3Sn]6+ core but contain a different arrangement of peripheral ligands. As far as the neutral cluster 1 is concerned, there is no bridging OAc ligand, while only one bridging OAc ligand is observed for cluster 2 and two are for cluster 3. The Mo-Mo distances are about 0.03-0.04 A shorter than those of the starting trimolybdenum clusters. This indicates that the incorporation of SnCl3- fragment into (Mo3) clusters makes the Mo-Mo bonding enhanced. Crystal data for 1: triclinic, space group P-1, a = 10.7423(2) A, b = 14.0357(1) A, c = 16.9346(2) A, alpha = 84.054(1) degrees, beta = 87.095(1) degrees, gamma = 84.517(1) degrees, V = 2525.82(6) A3, Z = 2, R = 0.038 for 5584 reflections (I > 2.0 sigma(I)). Crystal data for 2: triclinic, space group P-1, a = 12.9529(1) A, b = 15.6324(2) A, c = 19.6355(1) A, alpha = 92.083(1) degrees, beta = 97.908(1) degrees, gamma = 110.337(1) degrees, V = 3677.41(6) A3, Z = 2, R = 0.034 for 8665 reflections (I > 2.0 sigma(I)). Crystal data for 3: monoclinic, space group P2(1)/n, a = 14.0852(5) A, b = 15.1324(5) A, c = 23.2691(7) A, beta = 97.371(1) degrees, V = 4918.7(3) A3, Z = 4, R = 0.049 for 4970 reflections (I > 2.0 sigma(I)).     

Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design,synthesis and biological evaluation

A series of novel 2,4-diaminopyrimidine-modified compounds was designed and synthesized. Compound 14 showed micromolar dual inhibitory effect on both FP-2 and PfDHFR, and potential inhibition to the proliferation of P. falciparum 3D7 strain and chloroquine-resistant P. falciparum Dd2 strain.     

Controlled kinetics of non-enzymatic chemiluminescence reactions for simple imaging of DNA and protein

A robust and sensitive non-enzymatic chemiluminescence (CL) imaging method is presented. In the method a fast-emitting CL reaction is tuned to furnish a slower-emitting reaction suitable for simple CL imaging. Typically, non-enzymatic CL reactions between luminol or fluorescein and oxygen species generated by KCN as catalyst, were rather fast and unsuitable for CL imaging; the speed of the reactions could, however, be reduced substantially by changing KCN for CH(3)CN or benzonitrile. Light emission from the tuned CL reaction was intense and long-lived, and even with a simple arrangement high sensitivity could be achieved. The maximum CL peak was reached after approximately 1.5 min in the presence of 25% acetonitrile, and as little as 16 fmol commercial isoluminol-labeled streptavidin was detected and visualized on either microplate or membrane. The approach was further illustrated by imaging of DNA on a membrane and of antibody on a microplate by use of biotin-streptavidin chemistry. Overall, this simple, economical, and sensitive CL imaging system is expected to be very useful in biochemical analysis, and greatly complements currently used enzyme-based CL imaging methods, especially in routine applications.     

线性非理想条件下液相色谱柱末端峰形规律

 色谱流出曲线的二阶中心矩μ２和三阶中心矩μ３以及描述峰形非对称程度的偏态系数∑ｋ＝μ３／μ１．５２是反映色谱峰形的重要参数。从液相色谱过程动力学方程出发，运用电子计算机证明了在线性非理想条件下高效液相色谱体系中不同保留值组分在柱末端峰形的分布基本一致的结论。