Enantioselective synthesis of the carbacephem antibiotic loracarbef via Mitsunobu and Dieckmann cyclization from an unnatural amino acid

The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which was derived from enzyme-catalyzed condensation of glycine and 4-pentenaldehyde. The bicyclic framework of this compound was established through sequential Mitsunobu reaction and aldol condensations.     

On the importance of low-energy beta beams for supernova neutrino physics

We argue that isotropization and, consequently, thermalization of the system of gluons and quarks produced in an ultrarelativistic heavy-ion collision does not follow from Feynman diagram analysis to any order in the coupling constant. We conclude that the apparent thermalization of quarks and gluons, leading to success of perfect fluid hydrodynamics in describing heavy-ion collisions at RHIC, can only be attributed to the non-perturbative QCD effects not captured by Feynman diagrams. We proceed by modeling these non-pertrubative thermalization effects using viscous hydrodynamics. We point out that matching Color Glass Condensate inital conditions with viscous hydrodynamics leads to a continuous evolution of all the components of the energy-momentum tensor and, unlike the case of ideal hydrodynamics, does not give rise to a discontinuity in the longitudinal pressure. An important consequence of such a matching is a relationship between the thermalization time and shear viscosity: we observe that small viscosity leads to short thermalization time.     

Frequency-coded quantum key distribution

We report an intrinsically stable quantum key distribution scheme based on genuine frequency-coded quantum states. The qubits are efficiently processed without fiber interferometers by fully exploiting the nonlinear interaction occurring in electro-optic phase modulators. The system requires only integrated off-the-shelf devices and could be used with a true single-photon source. Preliminary experiments have been performed with weak laser pulses and have demonstrated the feasibility of this new setup.     

Absorbing Interface Conditions for the Simulation of Wave Propagation on Non-Uniform Meshes

We proposed absorbing interface conditions for the simulation of linear wave propagation on non-uniform meshes. Based on the superposition principle of second-order linear wave equations, we decompose the interface condition problem into two subproblems around the interface: for the first one the conventional artificial absorbing boundary conditions is applied, while for the second one, the local analytic solutions can be derived. The proposed interface conditions permit a two-way transmission of low-frequency waves across mesh interfaces which can be supported by both coarse and fine meshes, and perform a one-way absorption of high-frequency waves which can only be supported by fine meshes when they travel from fine mesh regions to coarse ones. Numerical examples are presented to illustrate the efficiency of the proposed absorbing interface conditions.