全文获取类型
收费全文 | 902篇 |
免费 | 21篇 |
国内免费 | 6篇 |
专业分类
化学 | 504篇 |
晶体学 | 23篇 |
力学 | 13篇 |
数学 | 184篇 |
物理学 | 205篇 |
出版年
2023年 | 8篇 |
2022年 | 14篇 |
2021年 | 10篇 |
2020年 | 14篇 |
2019年 | 9篇 |
2018年 | 6篇 |
2016年 | 13篇 |
2015年 | 16篇 |
2014年 | 23篇 |
2013年 | 49篇 |
2012年 | 34篇 |
2011年 | 49篇 |
2010年 | 20篇 |
2009年 | 22篇 |
2008年 | 48篇 |
2007年 | 46篇 |
2006年 | 42篇 |
2005年 | 44篇 |
2004年 | 41篇 |
2003年 | 27篇 |
2002年 | 51篇 |
2001年 | 11篇 |
2000年 | 7篇 |
1999年 | 11篇 |
1998年 | 11篇 |
1997年 | 6篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1988年 | 12篇 |
1987年 | 8篇 |
1986年 | 10篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 15篇 |
1981年 | 17篇 |
1980年 | 9篇 |
1979年 | 10篇 |
1978年 | 17篇 |
1977年 | 19篇 |
1976年 | 11篇 |
1975年 | 12篇 |
1974年 | 13篇 |
1973年 | 7篇 |
1967年 | 6篇 |
排序方式: 共有929条查询结果,搜索用时 31 毫秒
11.
Several aspects of past and current studies in the area of iminium salt photochemistry are discussed. Investigations of olefin-iminium salt photoaddition and photocyclization reactions are reviewed and conclusions about electron-transfer pathways for fluorescence quenching and reaction are discussed. The results of recent studies of alcohol and ether photoaddition to 2-phenyl-1-pyrrolinium salts are presented. These C-C bond forming processes occur in moderate yields to produce β-amino alcohol or ether products. In addition, alcohols and ethers serve as efficient quenchers of pyrrolinium salt fluorescence. Rate constants for quenching appear to be dependent upon both the oxidation potential of the alcohols and ethers and the availability of C-H bond α to oxygen. This data along with deuterium isotope effects on quenching combine to suggest a common mechanism for both fluorescence quenching and photoaddition. The nature of this mechanism is tested using the comparative quenching effeciencies of the tertiary alcohols t-butyl alcohol and 1,2,2-trimethyl-1-cyclopropanol. The latter alcohol having a weak C-C bond adjacent to the hydroxyl function quenches the fluorescence of 2-phenyl-1-pyrrolium salts at a rate two orders of magnitude greater than for t-butyl alcohol. The observations made are interpreted in terms of a sequential electron-proton transfer mechanism for quenching and photoaddition. Lastly, the relationship of iminium salt photochemical studies to other investigations of electron-transfer photochemistry is discussed. 相似文献
12.
Toward a microchip-based solid-phase extraction method for isolation of nucleic acids 总被引:7,自引:0,他引:7
Wolfe KA Breadmore MC Ferrance JP Power ME Conroy JF Norris PM Landers JP 《Electrophoresis》2002,23(5):727-733
A silica-based solid-phase extraction system suitable for incorporation into a microchip platform (nu-total analytical system; nu-TAS) would find utility in a variety of genetic analysis protocols, including DNA sequencing. The extraction procedure utilized is based on adsorption of the DNA onto bare silica. The procedure involves three steps: (i) DNA adsorption in the presence of a chaotropic salt, (ii) removal of contaminants with an alcohol/water solution, and (iii) elution of the adsorbed DNA in a small volume of buffer suitable for polymerase chain reaction (PCR) amplification. Multiple approaches for incorporation of this protocol into a microchip were examined with regard to extraction efficiency, reproducibility, stability, and the potential to provide PCR-amplifiable DNA. These included packing microchannels with silica beads only, generating a continuous silica network via sol-gel chemistry, and combinations of these. The optimal approach was found to involve immobilizing silica beads packed into the channel using a sol-gel network. This method allowed for successful extraction and elution of nanogram quantities of DNA in less than 25 min, with the DNA obtained in the elution buffer fraction. Evaluation of the eluted DNA indicated that it was of suitable quality for subsequent amplification by PCR. 相似文献
13.
The efficient catalytic activation of donor–acceptor aminocyclopropanes lacking the commonly used diester acceptor is reported here in a (3 + 2) dearomative annulation with indoles. Bench-stable tosyl-protected aminocyclopropyl esters were converted into cycloadducts in 46–95% yields and up to 95 : 5 diastereomeric ratio using catalytic amounts of triethylsilyl triflimide. Tricyclic indoline frameworks containing four stereogenic centers including all-carbon quaternary centers were obtained.A catalytic dearomatization of indoles with D–A aminocyclopropane monoesters for the synthesis of highly substituted indolines. 相似文献
14.
CIDNP has been studied during thermal decomposition, photolysis, and sensitized photolysis of benzoyl chloroacetyl peroxide. The ratio of the CIDNP intensities for the recombination products benzyl chloride and chloromethyl benzoate is dependent on the mode of decomposition, reflecting the extent of rapid decarboxylation of the primary formed benzoyloxy radicals. 相似文献
15.
Emtenäs H Ahlin K Pinkner JS Hultgren SJ Almqvist F 《Journal of combinatorial chemistry》2002,4(6):630-639
A new method for the solid-phase synthesis of enantiomerically enriched highly substituted ring-fused 2-pyridinones 13 has been developed. The synthesis mediates introduction of substituents at two positions in the 2-pyridinone ring in a diverse manner and is suitable for parallel synthesis. (19)F NMR spectroscopy was used as a tool to monitor each of the five steps in the reaction sequence. The optimized conditions thus obtained were then used to prepare a library of 20 2-pyridinones with high yields. The library members were chosen from a statistical multivariate design to ensure diversity and reliable data for structure-activity relationships. Screening of the library against the bacterial periplasmic chaperone PapD was performed using surface plasmon resonance. Three new 2-pyridinones with a higher affinity for the chaperone PapD than the previous best 13[10,1] were found, and important structural features could be deduced. 相似文献
16.
Abstract— Photohydrogen production, 200-700 μmol H2 h?1 (mg bacteriochlorophyll a)?1 has been obtained in a system containing unit membrane vesicles (Complex I) from the green photosynthetic bacterium Chiorobium limicola f. thiosulfatophilum, ascorbate, N,N,N′,N′-tetramethyl-p-phenylene-diamine, dithioerythritol, an oxygen scavenging mixture, either methyl viologen (MV) or clostridial ferredoxin (CPS Fd) as electron carrier, and either CPS hydrogenase or platinum asbestos as catalyst. All components are necessary for maximum activity, and spinach Fd cannot be substituted for CPS Fd. Higher rates of photohydrogen production are obtained using MV or CPS Fd with hydrogenase than with MV and Pt asbestos. The highest quantum efficiencies (7–10% at 0.2–0.9 mW absorbed light and over 20% at lower light) were obtained with CPS Fd, hydrogenase and non-saturating 812 nm light. With saturating white light, however, rates of photohydrogen production varied relatively little among the various combinations of electron carrier and catalyst tested. The reaction rate is unaffected by 0.03% Triton X-100, and is insensitive to treatment with antimycin a or m-chloro-carbonyl cyanide phenylhydrazone. This indicates that neither electron flow through an endogenous cyclic chain, nor maintenance of a proton gradient are involved in this process. 相似文献
17.
A series of acyclic vinyl ethers have been prepared and treated with Grubbs' ruthenium catalyst ((Cy3P)2RuCl2=CHPh). Contrary to previous findings, it has been shown that certain vinyl ethers are excellent substrates for the ring closing metathesis with ruthenium based catalysts. 相似文献
18.
A novel approach to the fabrication of metal ring-disk (RD) microelectrodes is presented that employs flexible chemical vapor deposition (CVD) and electrode modification techniques. Specifically, the development of a copper ring-disk microelectrode is described utilizing a combination of CVD coating, electroetching, and electroplating. Initially, a 25 μm diameter tungsten wire is concentrically coated by CVD with an insulating layer of silica, a layer of tungsten metal, and finally, a second outer layer of silica. The copper surface was prepared by first creating micrometer cavities by electrochemical etching the tungsten in hydroxide solutions followed by electrodeposition of copper from aqueous solutions of Cu(II). Each step of the process was characterized by scanning electron microscopy, optical microscopy, and cyclic voltammetry, demonstrating the preparation of a viable metal-based dual ring-disk microelectrode system. For the purpose of demonstrating the concept of introducing specific selectivity into the device, amperometric detection of galactose in 0.1 M NaOH was performed at +0.60 V in bulk solution and after flow injection analysis in a capillary column. 相似文献
19.
LetQ n β be the law of then-step random walk on ?d obtained by weighting simple random walk with a factore ?β for every self-intersection (Domb-Joyce model of “soft polymers”). It was proved by Greven and den Hollander (1993) that ind=1 and for every β∈(0, ∞) there exist θ*(β)∈(0,1) and such that under the lawQ n β asn→∞: $$\begin{array}{l} (i) \theta ^* (\beta ) is the \lim it empirical speed of the random walk; \\ (ii) \mu _\beta ^* is the limit empirical distribution of the local times. \\ \end{array}$$ A representation was given forθ *(β) andµ β β in terms of a largest eigenvalue problem for a certain family of ? x ? matrices. In the present paper we use this representation to prove the following scaling result as β?0: $$\begin{array}{l} (i) \beta ^{ - {\textstyle{1 \over 3}}} \theta ^* (\beta ) \to b^* ; \\ (ii) \beta ^{ - {\textstyle{1 \over 3}}} \mu _\beta ^* \left( {\left\lceil { \cdot \beta ^{ - {\textstyle{1 \over 3}}} } \right\rceil } \right) \to ^{L^1 } \eta ^* ( \cdot ) . \\ \end{array}$$ The limitsb *∈(0, ∞) and are identified in terms of a Sturm-Liouville problem, which turns out to have several interesting properties. The techniques that are used in the proof are functional analytic and revolve around the notion of epi-convergence of functionals onL 2(?+). Our scaling result shows that the speed of soft polymers ind=1 is not right-differentiable at β=0, which precludes expansion techniques that have been used successfully ind≧5 (Hara and Slade (1992a, b)). In simulations the scaling limit is seen for β≦10?2. 相似文献
20.
Let {X
t:0} denote random walk in the random waiting time model, i.e., simple random walk with jump ratew
–1(X
t), where {w(x):xd} is an i.i.d. random field. We show that (under some mild conditions) theintermediate scattering function
F(q,t)=E
0
(qd) is completely monotonic int (E
0 denotes double expectation w.r.t. walk and field). We also show that thedynamic structure factor
S(q, w)=2
0
cos(t)F(q, t) exists for 0 and is strictly positive. Ind=1, 2 it diverges as 1/||1/2, resp. –ln(||), in the limit 0; ind3 its limit value is strictly larger than expected from hydrodynamics. This and further results support the conclusion that the hydrodynamic region is limited to smallq and small such that ||D |q|2, whereD is the diffusion constant. 相似文献